Metal-based strategies for the fight against COVID-19

Hongyan Li, Shuofeng Yuan, Xueying Wei and Hongzhe Sun

Chem. Commun., 2022, 58, 7466
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Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication

David A. Davis, Ashwin Nair, Yana Astter, Emma Treco, Brian Peyser, Rick Gussio, Tam Nguyen, Brett Eaton, Elena Postnikova, Michael Murphy, Prabha Shrestha, Haydar Bulut, Shin-Ichiro Hattorri, Hiroaki Mitsuya and Robert Yarchoan

RSC Med. Chem., 2024, 15, 4193
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Discovery and characterization of the covalent SARS-CoV-2 3CLpro inhibitors from Ginkgo biloba extract via integrating chemoproteomic and biochemical approaches

Ya-Ni Zhang, Guang-Hao Zhu, Wei Liu, Yuan Xiong, Qing Hu, Xiao-Yu Zhuang, Gui-Hua Jia, Wei-Dong Zhang and Guang-Bo Ge

Phytomedicine, 2023, 114, 154796
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A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication

Christopher Moon, Eleanor Porges, Adam Roberts and Joanna Bacon

Antiviral Research, 2024, 225, 105859
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Allosteric Regulation and Inhibition of Coronavirus 3CLpro Revealed by HDX‐MS

Ning Song, Wen Zheng, Bin Song and Jie Zheng

ChemBioChem, 2024, 25
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Surface cysteines could protect the SARS-CoV-2 main protease from oxidative damage

Raheleh Ravanfar, Yuling Sheng, Mona Shahgholi, Brett Lomenick, Jeff Jones, Tsui-Fen Chou, Harry B. Gray and Jay R. Winkler

Journal of Inorganic Biochemistry, 2022, 234, 111886
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Metallo-antiviral aspirants: Answer to the upcoming virus outbreak

Ripul Mehrotra, Satyendra N. Shukla and Pratiksha Gaur

European Journal of Medicinal Chemistry Reports, 2023, 8, 100104
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SARS-CoV-2 Mpro Inhibitors: Achieved Diversity, Developing Resistance and Future Strategies

Conrad Fischer and Jenson R. Feys

Future Pharmacology, 2023, 3, 80
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SARS-CoV-2 main protease (M-pro) mutational profiling: An insight into mutation coldspots

Pol Garcia-Segura, Ariadna Llop-Peiró, Nil Novau-Ferré, Júlia Mestres-Truyol, Bryan Saldivar-Espinoza, Gerard Pujadas and Santiago Garcia-Vallvé

Computers in Biology and Medicine, 2025, 184, 109344
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Metal–Organic Frameworks: Unconventional Nanoweapons against COVID

Inés Álvarez-Miguel, Beatrice Fodor, Guillermo G. López, Catalina Biglione, Erik Svensson Grape, A. Ken Inge, Tania Hidalgo and Patricia Horcajada

ACS Appl. Mater. Interfaces, 2024, 16, 32118
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Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics

Yash Gupta, Oleksandr V. Savytskyi, Matt Coban, Amoghavarsha Venugopal, Vasili Pleqi, Caleb A. Weber, Rohit Chitale, Ravi Durvasula, Christopher Hopkins, Prakasha Kempaiah and Thomas R. Caulfield

Molecular Aspects of Medicine, 2023, 91, 101151
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Interaction of copper potential metallodrugs with TMPRSS2: A comparative study of docking tools and its implications on COVID-19

Sergio Vazquez-Rodriguez, Diego Ramírez-Contreras, Lisset Noriega, Amalia García-García, Brenda L. Sánchez-Gaytán, Francisco J. Melendez, María Eugenia Castro, Walter Filgueira de Azevedo and Enrique González-Vergara

Front. Chem., 2023, 11
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Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs

Mohamed A. Elrayess, Hadeel T. Zedan, Rand A. Alattar, Hatem Abusriwil, Mahmoud Khatib A. A. Al-Ruweidi, Shamma Almuraikhy, Jabeed Parengal, Bassem Alhariri, Hadi M. Yassine, Ali A. Hssain, Arun Nair, Musaed Al Samawi, Alaaeldin Abdelmajid, Jassim Al Suwaidi, Mohamed Omar Saad, Muna Al-Maslamani, Ali S. Omrani and Huseyin C. Yalcin

Blood Pressure, 2022, 31, 80
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Discovery of the covalent SARS‐CoV‐2 Mpro inhibitors from antiviral herbs via integrating target‐based high‐throughput screening and chemoproteomic approaches

Ya‐Ni Zhang, Guang‐Hao Zhu, Wei Liu, Xi‐Xiang Chen, Yuan‐Yuan Xie, Jian‐Rong Xu, Mei‐Fang Jiang, Xiao‐Yu Zhuang, Wei‐Dong Zhang, Hong‐Zhuan Chen and Guang‐Bo Ge

Journal of Medical Virology, 2023, 95
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Biochemical Screening of Phytochemicals and Identification of Scopoletin as a Potential Inhibitor of SARS-CoV-2 Mpro, Revealing Its Biophysical Impact on Structural Stability

Sarika Bano, Jyotishna Singh, Zainy Zehra, Md Nayab Sulaimani, Taj Mohammad, Seemasundari Yumlembam, Md Imtaiyaz Hassan, Asimul Islam and Sanjay Kumar Dey

Viruses, 2025, 17, 402
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The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

Qing Hu, Yuan Xiong, Guang‐Hao Zhu, Ya‐Ni Zhang, Yi‐Wen Zhang, Ping Huang and Guang‐Bo Ge

MedComm, 2022, 3
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Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Jânia dos Santos Rosário, Fábio Henrique Moreira, Lara Hewilin Fernandes Rosa, Wendell Guerra and Priscila Pereira Silva-Caldeira

Molecules, 2023, 28, 5921
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Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism

Guang-Hao Zhu, Ya-Ni Zhang, Yuan Xiong, Xu-Dong Hou, Qing-Guang Zhang, Zhao-Qin Zhang, Xiao-Yu Zhuang, Wei-Dong Zhang and Guang-Bo Ge

Journal of Pharmaceutical Analysis, 2025, 101224
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Targeting viral proteins for restraining SARS-CoV-2: focusing lens on viral proteins beyond spike for discovering new drug targets

Tao Yang, Si Chun Wang, Linyan Ye, Yasen Maimaitiyiming and Hua Naranmandura

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An in silico investigation of allosteric inhibition potential of Dihydroergotamine against Sars-CoV-2 Main Protease (MPro)

Mehmet Murat YAŞAR, Ekrem YAŞAR, Nuri YORULMAZ, Emin TENEKECİ, İsmail Hakkı SARPÜN and Erol EROĞLU

Turkish Comp Theo Chem (TC&TC), 2023, 7, 14
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Recent Advances on Targeting Proteases for Antiviral Development

Pedro Henrique Oliveira Borges, Sabrina Baptista Ferreira and Floriano Paes Silva

Viruses, 2024, 16, 366
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Disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site

Ying Kuan, Hsu-Feng Chu, Pang-Hung Hsu, Kai-Cheng Hsu, Ta-Hsien Lin, Chun-Hsiang Huang and Wei-Yi Chen

International Journal of Biological Macromolecules, 2024, 276, 133955
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Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol

Xuan Tao, Lu Zhang, Liubing Du, Kai Lu, Zhennan Zhao, Yanxuan Xie, Xiaobo Li, Shuxiang Huang, Pei-Hui Wang, Ji-An Pan, Wei Xia, Jun Dai and Zong-Wan Mao

Journal of Inorganic Biochemistry, 2022, 231, 111777
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Uncovering the naturally occurring covalent inhibitors of SARS-CoV-2 Mpro from the Chinese medicine sappanwood and deciphering their synergistic anti-Mpro effects

Qing Hu, Yi-Wen Zhang, Ya-Ni Zhang, Guang-Hao Zhu, Peng-Cheng Chen, Wei Liu, Xiao-Ping Hu, Fei-Feng Song, Zong-Fu Pan, Shui-Lian Zheng, Nong-Er Shen, Guang-Bo Ge and Ping Huang

Journal of Ethnopharmacology, 2025, 342, 119397
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Influence of EGCG oxidation on inhibitory activity against the SARS-CoV-2 main protease

Yufeng He, Meng Hao, Mingchuan Yang, Huimin Guo, Margaret P. Rayman, Xiangchun Zhang and Jinsong Zhang

International Journal of Biological Macromolecules, 2024, 274, 133451
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Pnictogen-Centered Cascade Exchangers for Thiol-Mediated Uptake: As(III)-, Sb(III)-, and Bi(III)-Expanded Cyclic Disulfides as Inhibitors of Cytosolic Delivery and Viral Entry

Bumhee Lim, Takehiro Kato, Celine Besnard, Amalia I. Poblador Bahamonde, Naomi Sakai and Stefan Matile

JACS Au, 2022, 2, 1105
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A potential allosteric inhibitor of SARS-CoV-2 main protease (Mpro) identified through metastable state analysis

Asma Fatima, Anupriya M. Geethakumari, Wesam S. Ahmed and Kabir H. Biswas

Front. Mol. Biosci., 2024, 11
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Fusing Bismuth and Mercaptocarboranes: Design and Biological Evaluation of Low‐Toxicity Antimicrobial Thiolato Complexes

Christoph Selg, Toni Grell, Alexandra Brakel, Philip C. Andrews, Ralf Hoffmann and Evamarie Hey‐Hawkins

ChemPlusChem, 2024, 89
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Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation

David A. Davis, Haydar Bulut, Prabha Shrestha, Hiroaki Mitsuya and Robert Yarchoan

Antioxidants, 2022, 11, 2054
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