Visualizing the cellular internalization of therapeutic antibodies via pH-sensitive release of AIEgen

Zai-Gang Han, Kaifeng He, Yi Zheng and Linghui Qian

Org. Biomol. Chem., 2024, 22, 4950
DOI: 10.1039/D4OB00512K

In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s

Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q. Yao, Su Zeng and Linghui Qian

Chem. Commun., 2022, 58, 1314
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Intra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live cell imaging and sorting

Yancen Dai, Yuko Sato, Bo Zhu, Tetsuya Kitaguchi, Hiroshi Kimura, Farid J. Ghadessy and Hiroshi Ueda

Chem. Sci., 2022, 13, 9739
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Advancements in molecular disassembly of optical probes: a paradigm shift in sensing, bioimaging, and therapeutics

Karolina Saczuk, Marta Dudek, Katarzyna Matczyszyn and Marco Deiana

Nanoscale Horiz., 2024, 9, 1390
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Chemical probe as specific detector of porcine protein or peptide in meat and meat-based products: Potential applications, challenges, and the way forward

Mohd Nurhadi Hamsar, Awis Qurni Sazili and Siti Farah Md Tohid

Journal of Agriculture and Food Research, 2024, 15, 101026
DOI: 10.1016/j.jafr.2024.101026

Rapid discovery and evolution of nanosensors containing fluorogenic amino acids

Erkin Kuru, Jonathan Rittichier, Helena de Puig, Allison Flores, Subhrajit Rout, Isaac Han, Abigail E. Reese, Thomas M. Bartlett, Fabio De Moliner, Sylvie G. Bernier, Jason D. Galpin, Jorge Marchand, William Bedell, Lindsey Robinson-McCarthy, Christopher A. Ahern, Thomas G. Bernhardt, David Z. Rudner, James J. Collins, Marc Vendrell and George M. Church

Nat Commun, 2024, 15
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A modular artificial intelligence framework to facilitate fluorophore design

Yuchen Zhu, Jiebin Fang, Shadi Ali Hassen Ahmed, Tao Zhang, Su Zeng, Jia-Yu Liao, Zhongjun Ma and Linghui Qian

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-58881-5

Antibody-based near-infrared fluorogenic probes for wash-free imaging of cell-surface proteins

Haoting Wang, Jiaqi Yan, Wenchao Wang, Endong Chen, Di Chen, Su Zeng, Quan Li and Linghui Qian

Analytica Chimica Acta, 2024, 1320, 343005
DOI: 10.1016/j.aca.2024.343005

Reduction-Activatable Fluorogenic Nanobody for Targeted and Low-Background Bioimaging

Qiang Peng, Tao Xiong, Fangling Ji, Jun Ren and Lingyun Jia

Anal. Chem., 2023, 95, 2804
DOI: 10.1021/acs.analchem.2c04132

Fluorescent labeling of live-cell surfaceome and its application in antibody-target interaction analysis

Haoting Wang, Ying Zhang, Wenchao Wang, Jinning Shao, Rizwan Ullah Khan, Su Zeng and Linghui Qian

Analytica Chimica Acta, 2024, 1330, 343296
DOI: 10.1016/j.aca.2024.343296

Benzimidazole-scaffold based fluorescent probes for sensing and bioimaging applications

JunHyuk Kim and Satish Balasaheb Nimse

Coordination Chemistry Reviews, 2025, 537, 216690
DOI: 10.1016/j.ccr.2025.216690

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels–Alder Cycloaddition: Application to Apelin

Timothé Maujean, Patrick Wagner, Christel Valencia, Stéphanie Riché, Xavier Iturrioz, Pascal Villa, Nicolas Girard, Julie Karpenko, Mihaela Gulea and Dominique Bonnet

Bioconjugate Chem., 2023, 34, 162
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The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Linghui Qian, Xuefen Lin, Xue Gao, Rizwan Ullah Khan, Jia-Yu Liao, Shubo Du, Jingyan Ge, Su Zeng and Shao Q. Yao

Chem. Rev., 2023, 123, 7782
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Targeted Degradation of Cell‐Surface Proteins via Chaperone‐Mediated Autophagy by Using Peptide‐Conjugated Antibodies

Jinning Shao, Xuefen Lin, Haoting Wang, Chuhan Zhao, Shao Q. Yao, Jingyan Ge, Su Zeng and Linghui Qian

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319232

Multimodal techniques and strategies for chemical and metabolic imaging at the single-cell level

Ajay Kesharwani and Vipul Gujrati

Current Opinion in Biotechnology, 2024, 88, 103149
DOI: 10.1016/j.copbio.2024.103149

Targeted Degradation of Cell‐Surface Proteins via Chaperone‐Mediated Autophagy by Using Peptide‐Conjugated Antibodies

Jinning Shao, Xuefen Lin, Haoting Wang, Chuhan Zhao, Shao Q. Yao, Jingyan Ge, Su Zeng and Linghui Qian

Angewandte Chemie, 2024, 136
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Systematic functional screening of switchable aptamer beacon probes

Xuan Cheng, Panzhu Yao, Chongyu Jin, Jinchen Long, Xueling Yan, Xuyang Zhao, Tongxuan Wei, Qinguo Liu, Yifan Chen, Huang Su, Hong Xuan, Siqi Bian, Jun Li, Wenlang Liu, Zheng Zheng and Liqin Zhang

Nat. Biomed. Eng, 2025
DOI: 10.1038/s41551-025-01503-8