Biosynthesis of cyclopropane in natural products

Suze Ma, Dhanaraju Mandalapu, Shu Wang and Qi Zhang

Nat. Prod. Rep., 2022, 39, 926
DOI: 10.1039/D1NP00065A

Biosynthesis of fungal terpenoids

Pan Luo, Jia-Hua Huang, Jian-Ming Lv, Gao-Qian Wang, Dan Hu and Hao Gao

Nat. Prod. Rep., 2024, 41, 748
DOI: 10.1039/D3NP00052D

Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability

Baofu Xu, Wenbo Ning, Xiuting Wei and Jeffrey D. Rudolf

Org. Biomol. Chem., 2022, 20, 8833
DOI: 10.1039/D2OB01931K

Class II terpene cyclases: structures, mechanisms, and engineering

Xingming Pan, Jeffrey D. Rudolf and Liao-Bin Dong

Nat. Prod. Rep., 2024, 41, 402
DOI: 10.1039/D3NP00033H

Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity

Fan Zhang, Di Zhao, Yuzhu Wu and Lei Li

Nat. Prod. Rep., 2025, 42, 1303
DOI: 10.1039/D5NP00011D

Biosynthesis of the tetrahydroxynaphthalene-derived meroterpenoid furaquinocin via reductive deamination and intramolecular hydroalkoxylation of an alkene

Tomohiro Noguchi, Fan Zhao, Yoshitaka Moriwaki, Hideaki Yamamoto, Kei Kudo, Ryuhei Nagata, Takeo Tomita, Tohru Terada, Kentaro Shimizu, Makoto Nishiyama and Tomohisa Kuzuyama

Chem. Sci., 2025, 16, 7912
DOI: 10.1039/D4SC08319A

Structural-model-based genome mining can efficiently discover novel non-canonical terpene synthases hidden in genomes of diverse species

Tohru Abe, Haruna Shiratori, Kosuke Kashiwazaki, Kazuma Hiasa, Daijiro Ueda, Tohru Taniguchi, Hajime Sato, Takashi Abe and Tsutomu Sato

Chem. Sci., 2024, 15, 10402
DOI: 10.1039/D4SC01381F

Total synthesis of cyclopropane-containing natural products: recent progress (2016–2024)

Neng Wang, Jin-Xin Zhao and Jian-Min Yue

Org. Chem. Front., 2025, 12, 2439
DOI: 10.1039/D4QO02316A

Strepyrrolins A–E, five pyrrole–sesquiterpene hybrids from Streptomyces sp. KIB 015, revealing a new formation logic of pyrroles by isotope labeling

Li Wang, Zhi Zhou, Jian-Ping Huang, Liang Zhang, Xiaotao Tuo, Zhiyin Yu, Sheng-Xiong Huang, Yang Liu and Jing Yang

Org. Chem. Front., 2023, 10, 880
DOI: 10.1039/D2QO01767A

Marine natural products

Anthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers and Michèle R. Prinsep

Nat. Prod. Rep., 2023, 40, 275
DOI: 10.1039/D2NP00083K

Genome mining reveals a highly oxidized bacterial perhydrophenanthrene meroterpenoid smelanic acid

Ziyi Yang, Xingming Pan, Lianchun Deng, Zengyuan Wang, Fang-Ru Li, Xiaoxu Lin, Hui-Min Xu and Liao-Bin Dong

Org. Biomol. Chem., 2025
DOI: 10.1039/D5OB01195G

Discovery of a plant-like tridomain bifunctional syn-abieta-7,13-diene synthase in Streptomyces

Caitlin A. McCadden, Diana P. Łomowska-Keehner, Tracy Qu, Jordan Nafie, Tyler A. Alsup and Jeffrey D. Rudolf

Org. Biomol. Chem., 2025
DOI: 10.1039/D5OB00724K

The insect microbiome is a vast source of bioactive small molecules

Carlismari Oliveira Grundmann, Juan Guzman, Andreas Vilcinskas and Mônica Tallarico Pupo

Nat. Prod. Rep., 2024, 41, 935
DOI: 10.1039/D3NP00054K

Biosynthesis, evolution and ecology of microbial terpenoids

Mariana Avalos, Paolina Garbeva, Lisa Vader, Gilles P. van Wezel, Jeroen S. Dickschat and Dana Ulanova

Nat. Prod. Rep., 2022, 39, 249
DOI: 10.1039/D1NP00047K

The role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis

Yuya Kakumu, Ayesha Ahmed Chaudhri and Eric J. N. Helfrich

Nat. Prod. Rep., 2025, 42, 501
DOI: 10.1039/D4NP00048J

Early-stage biosynthesis of phenalinolactone diterpenoids involves sequential prenylation, epoxidation, and cyclization

Tyler A. Alsup, Zining Li, Caitlin A. McCadden, Annika Jagels, Diana P. Łomowska-Keehner, Erin M. Marshall, Liao-Bin Dong, Sandra Loesgen and Jeffrey D. Rudolf

RSC Chem. Biol., 2024, 5, 1010
DOI: 10.1039/D4CB00138A

First trans-eunicellane terpene synthase in bacteria

Zining Li, Baofu Xu, Volga Kojasoy, Teresa Ortega, Donovon A. Adpressa, Wenbo Ning, Xiuting Wei, Jamin Liu, Dean J. Tantillo, Sandra Loesgen and Jeffrey D. Rudolf

Chem, 2023, 9, 698
DOI: 10.1016/j.chempr.2022.12.006

Canonical terpene synthases in arthropods: Intraphylum gene transfer

Xinlu Chen, John M. Urban, Jens Wurlitzer, Xiuting Wei, Jin Han, Sarah E. O’Connor, Jeffrey D. Rudolf, Tobias G. Köllner and Feng Chen

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
DOI: 10.1073/pnas.2413007121

Biosynthesis and Medicinal Value of Flavonoids and Chromones in Agarwood

Chen-Chen Fu, Bao-Xing Huang, Xinghao Zhang, Jian-Li Zhou, Shu-Yi Mao, Tai-Ping Fan, Jian-Hua Zhang, Shan-Shan Wang, Mo-Xian Chen and Fu-Yuan Zhu

J. Agric. Food Chem., 2025, 73, 16049
DOI: 10.1021/acs.jafc.5c02632

Four billion years of microbial terpenome evolution

Yosuke Hoshino and Laura Villanueva

FEMS Microbiology Reviews, 2023, 47
DOI: 10.1093/femsre/fuad008

The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines

Yin-Zhong Fan, Chun Tian, Shun-Yao Tong, Qing Liu, Fan Xu, Bao-Bao Shi, Hong-Lian Ai and Ji-Kai Liu

Nat. Prod. Bioprospect., 2023, 13
DOI: 10.1007/s13659-023-00407-x

The Phenazine Scaffold Used as Cytotoxic Pharmacophore Applied in Bactericidal, Antiparasitic and Antitumor Agents

Beata Miksa

Helvetica Chimica Acta, 2022, 105
DOI: 10.1002/hlca.202200066

Volatile organic compounds produced by thermophilic and non-thermophilic ampylobacter spp.: Influence of growth phase and nutrient composition

Filipe Magnum Dos Santos, Kah Hin Low and Lay Ching Chai

IFRJ, 2024, 31, 551
DOI: 10.47836/ifrj.31.3.02

Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase

Xingming Pan, Wenyu Du, Xiaowei Zhang, Xiaoxu Lin, Fang-Ru Li, Qian Yang, Hang Wang, Jeffrey D. Rudolf, Bo Zhang and Liao-Bin Dong

J. Am. Chem. Soc., 2022, 144, 22067
DOI: 10.1021/jacs.2c09412

Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities

Lu Cao, Jun-Feng Tan, Zeng-Guang Zhang, Jun-Wei Yang, Yu Mu, Zhi-Long Zhao, Yi Jiang, Xue-Shi Huang and Li Han

Nat. Prod. Bioprospect., 2024, 14
DOI: 10.1007/s13659-024-00481-9

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

Samantha C. Waterworth, Susan Egbert, John Sorensen, Barry R. O'Keefe and John A. Beutler

Environmental Microbiology, 2025, 27
DOI: 10.1111/1462-2920.70112

Whole-Genome Sequencing and Biosynthetic Gene Cluster Analysis of Novel Entomopathogenic Bacteria Xenorhabdus thailandensis ALN 7.1 and ALN 11.5

Wipanee Meesil, Jiranun Ardpairin, Liam K. R. Sharkey, Sacha J. Pidot, Apichat Vitta and Aunchalee Thanwisai

Biology, 2025, 14, 905
DOI: 10.3390/biology14080905

Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli

Fang-Ru Li, Xiaoxu Lin, Qian Yang, Ning-Hua Tan and Liao-Bin Dong

Beilstein J. Org. Chem., 2022, 18, 881
DOI: 10.3762/bjoc.18.89

Repositioning of HMG-CoA Reductase Inhibitors as Adjuvants in the Modulation of Efflux Pump-Mediated Bacterial and Tumor Resistance

Zsuzsanna Schelz, Hiba F. Muddather and István Zupkó

Antibiotics, 2023, 12, 1468
DOI: 10.3390/antibiotics12091468

Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase

Zhong Li, Lilan Zhang, Kangwei Xu, Yuanyuan Jiang, Jieke Du, Xingwang Zhang, Ling-Hong Meng, Qile Wu, Lei Du, Xiaoju Li, Yuechan Hu, Zhenzhen Xie, Xukai Jiang, Ya-Jie Tang, Ruibo Wu, Rey-Ting Guo and Shengying Li

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-39706-9

Functional Redundancy and Dual Function of a Hypothetical Protein in the Biosynthesis of Eunicellane-Type Diterpenoids

Ayesha Ahmed Chaudhri, Yuya Kakumu, Sirinthra Thiengmag, Jack Chun-Ting Liu, Geng-Min Lin, Suhan Durusu, Friederike Biermann, Miriam Boeck, Christopher A. Voigt, Jon Clardy, Reiko Ueoka, Allison S. Walker and Eric J. N. Helfrich

ACS Chem. Biol., 2024, 19, 2314
DOI: 10.1021/acschembio.4c00413

Advancement of uridine diphosphate-dependent glycosyltransferases (UGTs) in the glycosylation modification of natural products and their protein engineering

Zhongyang Liu, Lianghua Xie and Wei Chen

Food Quality and Safety, 2025, 9
DOI: 10.1093/fqsafe/fyaf005

Shotgun metagenomic insights into secondary metabolite biosynthetic gene clusters reveal taxonomic and functional profiles of microbiomes in natural farmland soil

Bezayit Amare Kifle, Amsale Melkamu Sime, Mesfin Tafesse Gemeda and Adugna Abdi Woldesemayat

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-63254-x

Are there conserved biosynthetic genes in lichens? Genome-wide assessment of terpene biosynthetic genes suggests ubiquitous distribution of the squalene synthase cluster

Garima Singh, Anna Pasinato, Alejandra López-Chicheri Yriarte, David Pizarro, Pradeep K. Divakar, Imke Schmitt and Francesco Dal Grande

BMC Genomics, 2024, 25
DOI: 10.1186/s12864-024-10806-0

Contribution of the gonococcal NEIS1446-ispD gene conversion to the pathobiology of the Neisseria meningitidis urethritis clade, Nm UC

Emilio I. Rodriguez, Yih-Ling Tzeng, Soma Sannigrahi, David S. Stephens and Kimberly A. Kline

Infect Immun, 2025, 93
DOI: 10.1128/iai.00350-24

Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island

Zi-Rong Zeng, Jing Chen, Hong Wang, Hai-Yan Zhang, Jia Li, Baofu Xu and Yue-Wei Guo

ACS Omega, 2022, 7, 41678
DOI: 10.1021/acsomega.2c05687

The biosynthesis of the odorant 2-methylisoborneol is compartmentalized inside a protein shell

Michael P. Andreas and Tobias W. Giessen

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-54175-4

Coenzyme A Tethering Mediates Dehydratase Substrate Promiscuity and Reaction Specificity in Platensimycin, Platencin, and Platensilin Biosynthesis

Lucas L. Fluegel, Andrew D. Steele, Edward Kalkreuter, Chun Gui, Dong Yang and Ben Shen

Biochemistry, 2025, 64, 3418
DOI: 10.1021/acs.biochem.5c00282

Modulation of Secondary Metabolites: A Halotolerance Strategy of Plant Growth Promoting Rhizobacteria Against Sodium Chloride Stress

Asad Ullah and Asghari Bano

Curr Microbiol, 2021, 78, 4050
DOI: 10.1007/s00284-021-02647-x

Rapid Assembly and Prototyping of Biocatalytic Virus-like Particle Nanoreactors

Lygie Esquirol, Donna McNeale, Trevor Douglas, Claudia E. Vickers and Frank Sainsbury

ACS Synth. Biol., 2022, 11, 2709
DOI: 10.1021/acssynbio.2c00117

Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes

Baiying Xing, Houchao Xu, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat, Donghui Yang and Ming Ma

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202209785

Discovery of cadinane sesquiterpenoids as GOT1 inhibitors from Penicillium sp. HZ-5

Yeting Zhang, Xinye Huang, Xinming Song, Xuan Li, Jinlong Zhang, Ming Chen, Zhengyi Shi, Binbin Song, Wei Wei, Changxing Qi and Yonghui Zhang

Bioorganic Chemistry, 2025, 157, 108303
DOI: 10.1016/j.bioorg.2025.108303

Identification and Characterization of Bifunctional Drimenol Synthases of Marine Bacterial Origin

Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi and Shunji Takahashi

ACS Chem. Biol., 2022, 17, 1226
DOI: 10.1021/acschembio.2c00163

Stable Isotopic Labeling of Dimethylallyl Pyrophosphate (DMAPP) Reveals Compartmentalization of Isoprenoid Biosynthesis during Sporulation in Bacillus subtilis

Dillon P. McBee, Zackary N. Hulsey, Makayla R. Hedges and Joshua A. Baccile

J. Am. Chem. Soc., 2025, 147, 19777
DOI: 10.1021/jacs.5c03639

Chemical synthesis of 13C-labeled isopentenyl pyrophosphate

Ruoyao Liu, Zhiyuan Ren, Zixin Deng, Min Xu and Anwei Hou

Tetrahedron, 2024, 168, 134356
DOI: 10.1016/j.tet.2024.134356

Sesquiterpenoids in Agarwood: Biosynthesis, Microbial Induction, and Pharmacological Activities

Xinghao Zhang, Lan Xiang Wang, Ruirui Hao, Jing jing Huang, Meisam Zargar, Mo-Xian Chen, Fu-Yuan Zhu and Hao-fu Dai

J. Agric. Food Chem., 2024, 72, 23039
DOI: 10.1021/acs.jafc.4c06383

Discovery of P450-Modified Sesquiterpenoids Levinoids A–D through Global Genome Mining

Wenchao Liu, Xueying Tian, Xin Huang, Jessie James Limlingan Malit, Chuanhai Wu, Zhihong Guo, Jian-Wei Tang and Pei-Yuan Qian

J. Nat. Prod., 2024, 87, 876
DOI: 10.1021/acs.jnatprod.3c01136

Confirmation of the stereochemistry of spiroviolene

Yao Kong, Yuanning Liu, Kaibiao Wang, Tao Wang, Chen Wang, Ben Ai, Hongli Jia, Guohui Pan, Min Yin and Zhengren Xu

Beilstein J. Org. Chem., 2024, 20, 852
DOI: 10.3762/bjoc.20.77

Genetic and biochemical diversity of terpene biosynthesis in cyanobacterial strains from tropical soda lakes

Mauricio J. Machado, Fernanda R. Jacinavicius, Rhuana V. Médice, Rafael B. Dextro, Anderson M. T. Feitosa, Marcio B. Weiss, Thierry A. Pellegrinetti, Simone R. Cotta, Camila M. Crnkovic and Marli F. Fiore

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1582103

The discovery of germacradienol synthase: Construction of genetically-engineered strain, glycosylated modification, bioactive evaluation of germacradienol

Guiding Li, Zengguang Zhang, Mengxia Wu, Xuemei Chen, Min Yin, Yi Jiang, Xueshi Huang, Chenglin Jiang and Li Han

Bioorganic Chemistry, 2022, 124, 105819
DOI: 10.1016/j.bioorg.2022.105819

Structure-guided product determination of the bacterial type II diterpene synthase Tpn2

Emma A. Stowell, Michelle A. Ehrenberger, Ya-Lin Lin, Chin-Yuan Chang and Jeffrey D. Rudolf

Commun Chem, 2022, 5
DOI: 10.1038/s42004-022-00765-6

Gene functions of the Ambystoma altamirani skin microbiome vary across space and time but potential antifungal genes are widespread and prevalent

Emanuel Martínez-Ugalde, Víctor Ávila-Akerberg, Tanya M. González Martínez and Eria A. Rebollar

Microbial Genomics, 2024, 10
DOI: 10.1099/mgen.0.001181

Microbial diversity and cover plants in de-sealed urban soil as strategies for mitigating anthropogenic volatile organic compounds

Maria Alexandra Cucu, Luisa Neri, Fabiano Sillo, Elisa Zampieri, Alice Calvo, Luca Giovannini, Cinzia De Benedictis, Alessandro Zaldei, Beniamino Gioli, Rita Baraldi and Raffaella Balestrini

Discov. Soil, 2024, 1
DOI: 10.1007/s44378-024-00022-3

Mechanistic Characterization of Diterpene Synthase Pairs for Tricyclic Diterpenes from Cyanobacteria

Jiayi Yu, Taro Shiraishi, Kizerbo A. Taizoumbe, Yusaku Karasuno, Ayako Yoshida, Makoto Nishiyama, Jeroen S. Dickschat and Tomohisa Kuzuyama

J. Am. Chem. Soc., 2025, 147, 11896
DOI: 10.1021/jacs.4c16710

Use of Emerging C-H Functionalization Methods to Implement Strategies for the Divergent Total Syntheses of Bridged Polycyclic Natural Products

Goh Sennari and Richmond Sarpong

J. Synth. Org. Chem. Jpn., 2023, 81, 1028
DOI: 10.5059/yukigoseikyokaishi.81.1028

Identification of two novel sesterterpene skeletons offers the first experimental evidence for the cyclization mechanism of mangicdiene synthase

Pan Luo, Jian-Ming Lv, Hong-Ting Zhen, Ying-Qi Zhao, Jing-Yuan Liu, Jin-Yu Hong, Shao-Yang Li, Gao-Qian Wang, Guo-Dong Chen, Shui-Xing Zhang, Dan Hu and Hao Gao

Chinese Chemical Letters, 2025, 111042
DOI: 10.1016/j.cclet.2025.111042

Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients

William Medeiros, Kelly Hidalgo, Tiago Leão, Lucas Miguel de Carvalho, Nadine Ziemert, Valeria Oliveira and Pedro Nuno Leão

Microbiol Spectr, 2024, 12
DOI: 10.1128/spectrum.00244-24

The role of isoprenoids in the chemical interaction between plants and other organisms in their rhizosphere

Harro Bouwmeester, Philipp Zerbe, Reuben J. Peters, Kangning Wang and Lemeng Dong

aBIOTECH, 2025
DOI: 10.1007/s42994-025-00225-4

Microbiome variation at the clam-sediment interface may explain changes in local productivity of Chamelea gallina in the North Adriatic sea

Giulia Trapella, Nicolò Cinti, Luca Parma, Antonina De Marco, Andrea Nicolò Dell’Acqua, Silvia Turroni, Simone Rampelli, Daniel Scicchitano, Letizia Iuffrida, Alessio Bonaldo, Silvia Franzellitti, Marco Candela and Giorgia Palladino

BMC Microbiol, 2023, 23
DOI: 10.1186/s12866-023-03146-8

Mechanistic Insights into the Formation of the 6,10‐Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4

Baofu Xu, Dean J. Tantillo and Jeffrey D. Rudolf

Angew Chem Int Ed, 2021, 60, 23159
DOI: 10.1002/anie.202109641

Characterisation and Identification of Bioactive Compounds from Flower Extracts of Myristica fragrans and Their Pharmacological Applications

V. Vishnupriya, K. Kavya and Tessy Anu Thomas

JNR, 2025, 1407
DOI: 10.18311/jnr/2025/48857

Chemical and genomic analyses of a marine-derived Streptomyces sp. V17-9 producing amino acid derivatives and siderophores

Da-Eun Kim, Sung-Chul Hong, Yoonyong Yang, Jaeyoung Choi and Jin-Soo Park

Front. Mar. Sci., 2022, 9
DOI: 10.3389/fmars.2022.959690

Molecular insights into a distinct class of terpenoid cyclases

Siyu Li, Jian-Wen Huang, Jian Min, Hao Li, Meidan Ning, Shuyu Zhou, Yu Yang, Chun-Chi Chen and Rey-Ting Guo

Nat Commun, 2025, 16
DOI: 10.1038/s41467-024-55717-6

Microbial secondary metabolites: advancements to accelerate discovery towards application

Jaime Lorenzo N. Dinglasan, Hiroshi Otani, Drew T. Doering, Daniel Udwary and Nigel J. Mouncey

Nat Rev Microbiol, 2025, 23, 338
DOI: 10.1038/s41579-024-01141-y

Total Syntheses of Polycyclic Diterpenes Phomopsene, Methyl Phomopsenonate, and iso-Phomopsene via Reorganization of C–C Single Bonds

Jun-Jie Yin, Yun-Peng Wang, Jun Xue, Feng-Fan Zhou, Xing-Qian Shan, Rong Zhu, Kun Fang, Lei Shi, Shu-Yu Zhang, Si-Hua Hou, Wujiong Xia and Yong-Qiang Tu

J. Am. Chem. Soc., 2023, 145, 21170
DOI: 10.1021/jacs.3c07044

Discovery of Diverse Sesquiterpenoids from Crossiella cryophila through Genome Mining and NMR Tracking

Shungen Chen, Qian Yang, Xiaowei Zhang, Zengyuan Wang, Hui-Min Xu and Liao-Bin Dong

J. Nat. Prod., 2024, 87, 195
DOI: 10.1021/acs.jnatprod.3c00830

The Natural Products Atlas 2.0: a database of microbially-derived natural products

Jeffrey A van Santen, Ella F Poynton, Dasha Iskakova, Emily McMann, Tyler A Alsup, Trevor N Clark, Claire H Fergusson, David P Fewer, Alison H Hughes, Caitlin A McCadden, Jonathan Parra, Sylvia Soldatou, Jeffrey D Rudolf, Elisabeth M-L Janssen, Katherine R Duncan and Roger G Linington

Nucleic Acids Research, 2022, 50, D1317
DOI: 10.1093/nar/gkab941

Drimane-type sesquiterpenoids from fungi

Wenyu DU, Qian YANG, Huimin XU and Liaobin DONG

Chinese Journal of Natural Medicines, 2022, 20, 737
DOI: 10.1016/S1875-5364(22)60190-0

Biosynthesis, enzymology, and future of eunicellane diterpenoids

Zining Li and Jeffrey D Rudolf

Journal of Industrial Microbiology and Biotechnology, 2023, 50
DOI: 10.1093/jimb/kuad027

Diterpenoids from Streptomyces: Structures, Biosyntheses and Bioactivities

Kai Gong, Daojing Yong, Jun Fu, Aiying Li, Youming Zhang and Ruijuan Li

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200231

Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs

Man-Cheng Tang, Cheng Shen, Zixin Deng, Masao Ohashi and Yi Tang

Org. Lett., 2022, 24, 4783
DOI: 10.1021/acs.orglett.2c01785

Discovery of sesquiterpenoids from an actinomycete Crossiella cryophila through genome mining and heterologous expression

Qian Yang, Jupeng Tian, Shungen Chen, Ziyi Yang, Zengyuan Wang, Hui-Min Xu and Liao-Bin Dong

Bioorganic Chemistry, 2024, 146, 107308
DOI: 10.1016/j.bioorg.2024.107308

Sustainable biosynthesis of valuable diterpenes in microbes

Yanbin Liu, Xixian Chen and Congqiang Zhang

Engineering Microbiology, 2023, 3, 100058
DOI: 10.1016/j.engmic.2022.100058

Expanding the Diversity of the Terpene Skeleton and Structure through Identification of Noncanonical Class IE and IF Terpene Synthase-Formed Products

Tohru Abe, Tohru Taniguchi, Daijiro Ueda, Takashi Abe and Tsutomu Sato

Org. Lett., 2025, 27, 6211
DOI: 10.1021/acs.orglett.5c01879

Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region

Rania Nassar, Mohannad Nassar, Lobna Mohamed, Abiola Senok and David Williams

Int Endodontic J, 2025, 58, 1091
DOI: 10.1111/iej.14227

Sedimentary diterpane origins—inferences from oils of varying source depositional environment and age

S. D. Killops, A. N. Bishop, E. W. Tegelaar, K. Urdal, M. R. K. Ghammari and J. W. H. Weijers

Front. Geochem., 2023, 1
DOI: 10.3389/fgeoc.2023.1241784

Unraveling the role of prenyl side-chain interactions in stabilizing the secondary carbocation in the biosynthesis of variexenol B

Moe Nakano, Rintaro Gemma and Hajime Sato

Beilstein J. Org. Chem., 2023, 19, 1503
DOI: 10.3762/bjoc.19.107

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020)

Fa-Lei Zhang and Tao Feng

JoF, 2022, 8, 244
DOI: 10.3390/jof8030244

Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in the Cyclization Mechanism of Tetraisoquinane

Xiuting Wei, William DeSnoo, Zining Li, Wenbo Ning, Wang-Yeuk Kong, Jordan Nafie, Dean J. Tantillo and Jeffrey D. Rudolf

J. Am. Chem. Soc., 2025, 147, 16293
DOI: 10.1021/jacs.5c01828

Unified Approach to ent-Eudesmane-Type Terpenoid Synthesis: Total Synthesis of Sinupol and Eutyscoparin A

Koichiro Ota, Kazuo Kamaike and Hiroaki Miyaoka

Synthesis, 2022, 54, 689
DOI: 10.1055/a-1643-5729

How rainfall events modify trace gas mixing ratios in central Amazonia

Luiz A. T. Machado, Jürgen Kesselmeier, Santiago Botía, Hella van Asperen, Meinrat O. Andreae, Alessandro C. de Araújo, Paulo Artaxo, Achim Edtbauer, Rosaria R. Ferreira, Marco A. Franco, Hartwig Harder, Sam P. Jones, Cléo Q. Dias-Júnior, Guido G. Haytzmann, Carlos A. Quesada, Shujiro Komiya, Jost Lavric, Jos Lelieveld, Ingeborg Levin, Anke Nölscher, Eva Pfannerstill, Mira L. Pöhlker, Ulrich Pöschl, Akima Ringsdorf, Luciana Rizzo, Ana M. Yáñez-Serrano, Susan Trumbore, Wanda I. D. Valenti, Jordi Vila-Guerau de Arellano, David Walter, Jonathan Williams, Stefan Wolff and Christopher Pöhlker

Atmos. Chem. Phys., 2024, 24, 8893
DOI: 10.5194/acp-24-8893-2024

The genetics of aerotolerant growth in an alphaproteobacterium with a naturally reduced genome

Amy L. Enright, Amy B. Banta, Ryan D. Ward, Julio Rivera Vazquez, Magdalena M. Felczak, Michael B. Wolfe, Michaela A. TerAvest, Daniel Amador-Noguez, Jason M. Peters, Dianne K. Newman and Jeffrey A. Gralnick

mBio, 2023, 14
DOI: 10.1128/mbio.01487-23

Kristallstrukturbasierte Mutagenese der Cattleyene‐Synthase führt zur Bildung umgelagerter polycyclischer Diterpene

Baiying Xing, Houchao Xu, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat, Donghui Yang and Ming Ma

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202209785

Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity

Jamshid Amiri Moghaddam, Huijuan Guo, Karsten Willing, Thomas Wichard and Christine Beemelmanns

Beilstein J. Org. Chem., 2022, 18, 722
DOI: 10.3762/bjoc.18.72

Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis**

Zengyuan Wang, Qian Yang, Jingyi He, Haixin Li, Xingming Pan, Zining Li, Hui‐Min Xu, Jeffrey D. Rudolf, Dean J. Tantillo and Liao‐Bin Dong

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202312490

Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis

Tingting Lou, Annan Li, Houchao Xu, Jingfeng Pan, Baiying Xing, Ruibo Wu, Jeroen S. Dickschat, Donghui Yang and Ming Ma

J. Am. Chem. Soc., 2023, 145, 8474
DOI: 10.1021/jacs.3c00278

Enzymatic reactions in teleocidin B biosynthesis

Takayoshi Awakawa

J Nat Med, 2021, 75, 467
DOI: 10.1007/s11418-021-01504-2

Bioinformatics Analysis of the Genome of Rhodococcus rhodochrous IEGM 1362, an (−)-Isopulegol Biotransformer

Polina Yu. Maltseva, Natalia A. Plotnitskaya, Anastasiia V. Krivoruchko, Aleksey V. Beletskiy, Andrey L. Rakitin, Andrey V. Mardanov and Irina B. Ivshina

Genes, 2024, 15, 992
DOI: 10.3390/genes15080992

Anti-cervical cancer mechanism of bioactive compounds from Alangium platanifolium based on the ‘compound-target-disease’ network

Hao Zhang, Ruiming Zhang, Yuefen Su, Jingrou Zheng, Hui Li, Zhichao Han, Yunzhen Kong, Han Liu, Zhen Zhang and Chunmei Sai

Heliyon, 2023, 9, e20747
DOI: 10.1016/j.heliyon.2023.e20747

Natural product biosynthetic potential reflects macroevolutionary diversification within a widely distributed bacterial taxon

Sandra Godinho Silva, Masun Nabhan Homsi, Tina Keller-Costa, Ulisses Rocha, Rodrigo Costa and Marnix Medema

mSystems, 2023, 8
DOI: 10.1128/msystems.00643-23

Membrane Permeant Analogs for Independent Cellular Introduction of the Terpene Precursors Isopentenyl‐ and Dimethylallyl‐Pyrophosphate

Francis M. Rossi, Dillon P. McBee, Thomas N. Trybala, Zackary N. Hulsey, Camila Gonzalez Curbelo, William Mazur and Joshua A. Baccile

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202200512

Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents

Ekaterina V. Tarasova, Natalia A. Luchnikova, Victoria V. Grishko and Irina B. Ivshina

Pharmaceuticals, 2023, 16, 872
DOI: 10.3390/ph16060872

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning” Method for Mechanistic Investigations of Terpene Cyclases

Shouqi Zhang, Kaibiao Wang, Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan and Zhengren Xu

ACS Catal., 2024, 14, 17598
DOI: 10.1021/acscatal.4c05811

The potential role of plant secondary metabolites on antifungal and immunomodulatory effect

Xue Zhou, Meng Zeng, Fujiao Huang, Gang Qin, Zhangyong Song and Fangyan Liu

Appl Microbiol Biotechnol, 2023, 107, 4471
DOI: 10.1007/s00253-023-12601-5

Comparative Genomic and Metabolomic Analysis of Termitomyces Species Provides Insights into the Terpenome of the Fungal Cultivar and the Characteristic Odor of the Fungus Garden of Macrotermes natalensis Termites

Nina B. Kreuzenbeck, Elena Seibel, Jan W. Schwitalla, Janis Fricke, Benjamin H. Conlon, Suzanne Schmidt, Almuth Hammerbacher, Tobias G. Köllner, Michael Poulsen, Dirk Hoffmeister, Christine Beemelmanns and Monica T. Pupo

mSystems, 2022, 7
DOI: 10.1128/msystems.01214-21

Mechanistic Perspective on C–N and C–S Bond Construction Catalyzed by Cytochrome P450 Enzymes

Tai-Ping Zhou, Yakun Fan, Jinyan Zhang and Binju Wang

ACS Bio Med Chem Au, 2025, 5, 16
DOI: 10.1021/acsbiomedchemau.4c00100

Revision of the Peniroquesine Biosynthetic Pathway by Retro-Biosynthetic Theoretical Analysis: Ring Strain Controls the Unique Carbocation Rearrangement Cascade

Taro Matsuyama, Ko Togashi, Moe Nakano, Hajime Sato and Masanobu Uchiyama

JACS Au, 2023, 3, 1596
DOI: 10.1021/jacsau.3c00039

Marine Bacteria: A Source of Novel Bioactive Natural Products

Xiangru Zha, Rong Ji and Songlin Zhou

CMC, 2024, 31, 6842
DOI: 10.2174/0929867331666230821102521

TRANSITION METAL NANOPARTICLES AS PROMISING ANTIMICROBIAL AGENTS

VINOD KUMAR VASHISTHA, RENU BALA, DIPAK KUMAR DAS, ANKIT MITTAL and RAJASEKHAR VSR PULLABHOTLA

Surf. Rev. Lett., 2024, 31
DOI: 10.1142/S0218625X24300041

Cryptic Isomerization in Diterpene Biosynthesis and the Restoration of an Evolutionarily Defunct P450

Zining Li, Baofu Xu, Tyler A. Alsup, Xiuting Wei, Wenbo Ning, Daniel G. Icenhour, Michelle A. Ehrenberger, Ion Ghiviriga, Bao-Doan Giang and Jeffrey D. Rudolf

J. Am. Chem. Soc., 2023, 145, 22361
DOI: 10.1021/jacs.3c09446

Genome-Driven Discovery of Antiviral Atralabdans A–C from the Soil-Dwelling Streptomyces atratus

Ling Shen, Yanyan Wang, Chengxin Liu, Wula Alateng, Yuxin Wang, Axel Zeeck, Weiguang Wang, Peng Zhang, Yanhong Wei and Xiaofeng Cai

J. Nat. Prod., 2024, 87, 1735
DOI: 10.1021/acs.jnatprod.4c00225

Unusual Sesquiterpenes from Streptomyces olindensis DAUFPE 5622

Fernanda O. Chagas, Leandro M. Garrido, Raphael Conti, Ricardo M. Borges, Vincent A. Bielinski, Gabriel Padilla and Mônica T. Pupo

J. Nat. Prod., 2024, 87, 491
DOI: 10.1021/acs.jnatprod.3c00752

Biological Demands and Toxicity of Isoprenoid Precursors in Bacillus Subtilis Through Cell‐Permeant Analogs of Isopentenyl Pyrophosphate and Dimethylallyl Pyrophosphate

Dillon P. McBee, Zackary N. Hulsey, Makayla R. Hedges and Joshua A. Baccile

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400064

Bacterial Diterpene Synthases Prenylate Small Molecules

Baofu Xu, Zining Li, Tyler A. Alsup, Michelle A. Ehrenberger and Jeffrey D. Rudolf

ACS Catal., 2021, 11, 5906
DOI: 10.1021/acscatal.1c01113

Development of a Golden Gate Assembly-Based Genetic Toolbox for Lactiplantibacillus plantarum and Its Application for Engineering Monoterpenoid Biosynthesis

Xiangang Li, Pascal Y. Schönberg, Tabea Wucherpfennig, Christoph Hinze, Flavia Sulaj, Thomas Henle and Thorsten Mascher

ACS Synth. Biol., 2024, 13, 2764
DOI: 10.1021/acssynbio.4c00075

Bioactive Components in Traditional Foods Aimed at Health Promotion: A Route to Novel Mechanistic Insights and Lead Molecules?

Renger F. Witkamp

Annu. Rev. Food Sci. Technol., 2022, 13, 315
DOI: 10.1146/annurev-food-052720-092845

Exploring and expanding the natural chemical space of bacterial diterpenes

Xiuting Wei, Wenbo Ning, Caitlin A. McCadden, Tyler A. Alsup, Zining Li, Diana P. Łomowska-Keehner, Jordan Nafie, Tracy Qu, Melvin Osei Opoku, Glen R. Gillia, Baofu Xu, Daniel G. Icenhour and Jeffrey D. Rudolf

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-57145-6

Mechanistische Charakterisierung und Engineering der Sesterviolen‐Synthase aus Streptomyces violens

Binbin Gu, Bernd Goldfuss and Jeroen S. Dickschat

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202215688

Aroma evolution in lychee Juice: Distinct effects of water kefir grains and liquid cultures on volatile profiles

Xuan Chen, Junhan Xiang, Kaifeng Chen, Shuo Zhang, Da Ma, Shan Xiao, Xiaoqin Pan, Bo Wang, Shuting Zhang and Ji-hui Wang

LWT, 2025, 228, 118071
DOI: 10.1016/j.lwt.2025.118071

Untargeted Metabolomics Approach of Cross-Adaptation in Salmonella Enterica Induced by Major Compounds of Essential Oils

Jorge Pamplona Pagnossa, Gabriele Rocchetti, Jadson Diogo Pereira Bezerra, Gaber El-Saber Batiha, Eman A. El-Masry, Mohamed H. Mahmoud, Abdulrahman A. Alsayegh, Abdullah Mashraqi, Pier Sandro Cocconcelli, Cledir Santos, Luigi Lucini and Roberta Hilsdorf Piccoli

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.769110

Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis**

Zengyuan Wang, Qian Yang, Jingyi He, Haixin Li, Xingming Pan, Zining Li, Hui‐Min Xu, Jeffrey D. Rudolf, Dean J. Tantillo and Liao‐Bin Dong

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202312490

Tailoring Enzyme Stringency Masks the Multispecificity of a Lyngbyatoxin (Indolactam Alkaloid) Nonribosomal Peptide Synthetase

Angela H. Soeriyadi, Sarah E. Ongley, Jan‐Christoph Kehr, Russel Pickford, Elke Dittmann and Brett A. Neilan

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100574

Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus

Dongxu Zhang, Wenyu Du, Xingming Pan, Xiaoxu Lin, Fang-Ru Li, Qingling Wang, Qian Yang, Hui-Min Xu and Liao-Bin Dong

Beilstein J. Org. Chem., 2024, 20, 815
DOI: 10.3762/bjoc.20.73

Biochemical and Genetic Basis of Guanacastane Diterpene Biosynthesis in Basidiomycete Fungi

Juan He, Jiao-Xian Du, Qian-Ru Zhao, Ya-Pei Liu, Yan-Long Yang, Ji-Kai Liu and Tao Feng

Org. Lett., 2023, 25, 5345
DOI: 10.1021/acs.orglett.3c01924

Mechanistic Insights into the Formation of the 6,10‐Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4

Baofu Xu, Dean J. Tantillo and Jeffrey D. Rudolf

Angewandte Chemie, 2021, 133, 23343
DOI: 10.1002/ange.202109641

Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway

Yoko Yasuno, Atsushi Nakayama, Kai Saito, Kohei Kitsuwa, Hironori Okamura, Mutsumi Komeyama, Hisashi Hemmi and Tetsuro Shinada

J. Nat. Prod., 2021, 84, 2749
DOI: 10.1021/acs.jnatprod.1c00615

Mechanistic Characterisation and Engineering of Sesterviolene Synthase from Streptomyces violens

Binbin Gu, Bernd Goldfuss and Jeroen S. Dickschat

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202215688

Exploring the Significance and Cutting-Edge Applications of Terpenes and Terpenoid-Derived Inorganic Nanoparticles

Pooja Mishra, Salman khan, Zeeshan Rafi, Tabrez Faruqui, Shazia Mansoor, Irshad Ahmad, Irfan Ahmad, Samra Siddiqui and Mohd Saeed

sci adv mater, 2024, 16, 665
DOI: 10.1166/sam.2024.4688

Combining Transcriptome- and Metabolome-Analyzed Differentially Expressed Genes and Differential Metabolites in Development Period of Caoyuanheimo-1 (Agaricus sp.) from Inner Mongolia, China

Hai-yan Wang, Ya-nan Lu, Ya-jiao Li, Guo-qin Sun, Yuan Wu, Rui-qing Ji and Wei Yan

Horticulturae, 2024, 10, 469
DOI: 10.3390/horticulturae10050469