DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery

Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang and Kemin Wang

Analyst, 2017, 142, 3322
DOI: 10.1039/C7AN01154G

Sensitive and specific detection of tumour cells based on a multivalent DNA nanocreeper and a multiplexed fluorescence supersandwich

Lei Luo, Wenshan Li, Dongliu Xiang, Yanyun Ma, Yuan Zhou, Yaqing Xu, Nandi Chen, Qing Wang, Jin Huang, Jianbo Liu, Xiaohai Yang and Kemin Wang

Chem. Commun., 2020, 56, 3693
DOI: 10.1039/C9CC08618H

BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer immunotherapy

Huijie Zhang, Ting Cheng, Li Lai, Shuhao Deng, Ruixi Yu, Lipeng Qiu, Juan Zhou, Guozhong Lu, Chunyi Zhi and Jinghua Chen

Nanoscale, 2018, 10, 14516
DOI: 10.1039/C8NR03820A

Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

Guangli Li, Junjie Li and Qing Li

Nanoscale, 2019, 11, 20456
DOI: 10.1039/C9NR06436B

A DNA nanowire based localized catalytic hairpin assembly reaction for microRNA imaging in live cells

Qiaomei Wei, Jin Huang, Jing Li, Jiaoli Wang, Xiaohai Yang, Jianbo Liu and Kemin Wang

Chem. Sci., 2018, 9, 7802
DOI: 10.1039/C8SC02943A

Growing prospects of DNA nanomaterials in novel biomedical applications

Zhiguang Suo, Jingqi Chen, Xialing Hou, Ziheng Hu, Feifei Xing and Lingyan Feng

RSC Adv., 2019, 9, 16479
DOI: 10.1039/C9RA01261C

DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy

Qingjia Chi, Zichang Yang, Kang Xu, Chunli Wang and Huaping Liang

Front. Pharmacol., 2020, 10
DOI: 10.3389/fphar.2019.01585

I-Motif-Based in Situ Bipedal Hybridization Chain Reaction for Specific Activatable Imaging and Enhanced Delivery of Antisense Oligonucleotides

Wenjie Ma, Biao Chen, Shanzi Zou, Ruichen Jia, Hong Cheng, Jin Huang, Huizhen Wang, Xiaoxiao He and Kemin Wang

Anal. Chem., 2019, 91, 12538
DOI: 10.1021/acs.analchem.9b03420

DNA-based hydrogels for bone regeneration: A promising tool for bone organoids

Xiang Wu, Yan Hu, Shihao Sheng, Huijian Yang, Zuhao Li, Qinglin Han, Qin Zhang and Jiacan Su

Materials Today Bio, 2025, 31, 101502
DOI: 10.1016/j.mtbio.2025.101502

PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination

Xiang Liu, Qi Su, Huijuan Song, Xiaoguang Shi, Yumin Zhang, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong and Weiwei Wang

Biomaterials, 2021, 275, 120921
DOI: 10.1016/j.biomaterials.2021.120921

In Situ Hand-in-Hand DNA Tile Assembly: A pH-Driven and Aptamer-Targeted DNA Nanostructure for TK1 mRNA Visualization and Synergetic Killing of Cancer Cells

Wenjie Ma, Biao Chen, Ruichen Jia, Huanhuan Sun, Jin Huang, Hong Cheng, Huizhen Wang, Xiaoxiao He and Kemin Wang

Anal. Chem., 2021, 93, 10511
DOI: 10.1021/acs.analchem.1c01453

Cationic Starch Nanoparticles for Enhancing CpG Oligodeoxynucleotide-Mediated Antitumor Immunity

Jiawen Zhang, Shuo Wang, Honghui Huang, Hongqian Chen, Jinghua Chen and Huijie Zhang

Biomacromolecules, 2023, 24, 5898
DOI: 10.1021/acs.biomac.3c00917

Functional Immunostimulating DNA Materials: The Rising Stars for Cancer Immunotherapy

Ziwen Dai, Lei Wang and Zhigang Wang

Macromolecular Bioscience, 2021, 21
DOI: 10.1002/mabi.202100083

Self-assembled nanovehicle-mediated co-encapsulation of inactivated EV71 virus and CpG oligonucleotides elicits potent anti-EV71 humoral and cellular immune protective responses

Hao Liang, Xiangqian Xiao, Xiaofei Zhang, Qin Hu, Yishu Yang, Shan Cen, Xiongwei Deng and Wang Sheng

Biochemical and Biophysical Research Communications, 2019, 511, 253
DOI: 10.1016/j.bbrc.2019.02.014

Rational Vaccinology: Harnessing Nanoscale Chemical Design for Cancer Immunotherapy

Ziyin Huang, Cassandra E. Callmann, Shuya Wang, Matthew K. Vasher, Michael Evangelopoulos, Sarah Hurst Petrosko and Chad A. Mirkin

ACS Cent. Sci., 2022, 8, 692
DOI: 10.1021/acscentsci.2c00227

Self‐Assembled Supramolecular Nanoparticles for Targeted Delivery and Combination Chemotherapy

Bingjie Li, Zhenzhen Feng, Leiliang He, Wenshan Li, Qing Wang, Jianbo Liu, Jin Huang, Yan Zheng, Yanyun Ma, Xiaohai Yang and Kemin Wang

ChemMedChem, 2018, 13, 2037
DOI: 10.1002/cmdc.201800291

Cationic polymers for enhancing CpG oligodeoxynucleotides-mediated cancer immunotherapy

Jingru Fu, Jia Cai, Guixia Ling, Anning Li, Jiawei Zhao, Xingjie Guo and Peng Zhang

European Polymer Journal, 2019, 113, 115
DOI: 10.1016/j.eurpolymj.2018.12.044

Bioinspired DNA self-assembly for targeted cancer cell imaging and drug delivery

Si Sun, Qian-Ru Xiao, Jing Wei, Ying-Ying Wei, Yang Wang, Peng-Cheng Gao and Yong Jiang

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 585, 124182
DOI: 10.1016/j.colsurfa.2019.124182

G-quadruplex-based CpG oligodeoxynucleotide/DOTAP complex strongly stimulates immunity in CpG motif-specific and loop-length-dependent manners

Anh Thi Tram Tu, Kazuaki Hoshi, Miwako Shobo and Tomohiko Yamazaki

Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 40, 102508
DOI: 10.1016/j.nano.2021.102508

Self-Assembled DNA Nanostructures-Based Nanocarriers Enabled Functional Nucleic Acids Delivery

Jin Huang, Wenjie Ma, Huanhuan Sun, Huizhen Wang, Xiaoxiao He, Hong Cheng, Mingmin Huang, Yanli Lei and Kemin Wang

ACS Appl. Bio Mater., 2020, 3, 2779
DOI: 10.1021/acsabm.9b01197

DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy

Run Tian, Yingxu Shang, Yiming Wang, Qiao Jiang and Baoquan Ding

Small Methods, 2023, 7
DOI: 10.1002/smtd.202201518

Designing Multivalent Ligands to Control Biological Interactions: From Vaccines and Cellular Effectors to Targeted Drug Delivery

Ammar Arsiwala, Ana Castro, Steven Frey, Mark Stathos and Ravi S. Kane

Chemistry An Asian Journal, 2019, 14, 244
DOI: 10.1002/asia.201801677

Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA

Wenqing Liao, Sakiko Akahira, Rintaro Iwata Hara, Takeshi Wada, Kosuke Kusamori, Yoshinobu Takakura and Makiya Nishikawa

Biological & Pharmaceutical Bulletin, 2020, 43, 1188
DOI: 10.1248/bpb.b20-00052

Targeting Delivery of Oligodeoxynucleotides to Macrophages by Mannosylated Cationic Albumin for Immune Stimulation in Cancer Treatment

Shu-Lun Ai, Xiao-Yan He, Buo-Ya Liu, Ren-Xi Zhuo and Si-Xue Cheng

Mol. Pharmaceutics, 2019, 16, 2616
DOI: 10.1021/acs.molpharmaceut.9b00184

Enhanced Immunostimulatory Activity of Covalent DNA Dendrons

Yusuke Kawamoto, Wen Liu, Ji Hye Yum, Soyoung Park, Hiroshi Sugiyama, Yuki Takahashi and Yoshinobu Takakura

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100583

Polyvalent Nucleic Acid Nanoprobes for Cancer Diagnosis and Therapy

Wenjie Ma, Jinyan Li, He Zhang, Ke Quan, Yanli Lei, Le Yang, Linlin Wu and Zhihe Qing

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202404760

Polyethylenimine-Mediated CpG Oligodeoxynucleotide Delivery Stimulates Bifurcated Cytokine Induction

Ting Cheng, Jianhua Miao, Dan Kai and Huijie Zhang

ACS Biomater. Sci. Eng., 2018, 4, 1013
DOI: 10.1021/acsbiomaterials.8b00049

Immune Cycle‐Based Strategies for Cancer Immunotherapy

Yanhua Li, Xiaohan Liu, Xia Zhang, Wei Pan, Na Li and Bo Tang

Adv Funct Materials, 2021, 31
DOI: 10.1002/adfm.202107540

A Dual Macrophage Targeting Nanovector for Delivery of Oligodeoxynucleotides To Overcome Cancer-Associated Immunosuppression

Xiao-Yan He, Bo-Ya Liu, Jin-Long Wu, Shu-Lun Ai, Ren-Xi Zhuo and Si-Xue Cheng

ACS Appl. Mater. Interfaces, 2017, 9, 42566
DOI: 10.1021/acsami.7b13594

Target-activated multivalent sensing platform for improving the sensitivity and selectivity of Hg2+ detection

Dongyan Li, Yuxiong Lv, Huaiyue Xia, Jing Huang, Wenjie Liu, Jianna Yu, Guoxing Jing, Wen Liu, Yingying Sun and Wenshan Li

Analytica Chimica Acta, 2023, 1256, 341123
DOI: 10.1016/j.aca.2023.341123

The applications of functionalized DNA nanostructures in bioimaging and cancer therapy

Yun Zeng, Rachel L. Nixon, Wenyan Liu and Risheng Wang

Biomaterials, 2021, 268, 120560
DOI: 10.1016/j.biomaterials.2020.120560

Silk Fibroin for CpG Oligodeoxynucleotide Delivery

Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu and Jinghua Chen

ACS Biomater. Sci. Eng., 2019, 5, 6082
DOI: 10.1021/acsbiomaterials.9b01413

Enhanced Immunostimulatory Activity of a Cytosine-Phosphate-Guanosine Immunomodulator by the Assembly of Polymer DNA Wires and Spheres

Wenqian Yu, Junlin Sun, Feng Liu, Shuyi Yu, Zhen Xu, Fuan Wang and Xiaoqing Liu

ACS Appl. Mater. Interfaces, 2020, 12, 17167
DOI: 10.1021/acsami.9b21075

Pure DNA scaffolded drug delivery systems for cancer therapy

Hanane Aliouat, Ying Peng, Zoya Waseem, Shengfeng Wang and Wenhu Zhou

Biomaterials, 2022, 285, 121532
DOI: 10.1016/j.biomaterials.2022.121532

Improving DNA nanostructure stability: A review of the biomedical applications and approaches

Mahboobeh Nasiri, Mehrnoosh Bahadorani, Kristen Dellinger, Shyam Aravamudhan, Juan L. Vivero-Escoto and Reza Zadegan

International Journal of Biological Macromolecules, 2024, 260, 129495
DOI: 10.1016/j.ijbiomac.2024.129495