Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review

Abeer H. Elmaidomy, Nourhan Hisham Shady, Khaled Mohamed Abdeljawad, Mohamed Badran Elzamkan, Hussein Hykel Helmy, Emad Ashour Tarshan, Abanoub Nabil Adly, Yasmin Hamdy Hussien, Nesma Gamal Sayed, Ahmed Zayed and Usama Ramadan Abdelmohsen

RSC Adv., 2022, 12, 29078
DOI: 10.1039/D2RA04884A

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Senhua Chen, Runlin Cai, Zhaoming Liu, Hui Cui and Zhigang She

Nat. Prod. Rep., 2022, 39, 560
DOI: 10.1039/D1NP00041A

Bioactivities and molecular networking-based elucidation of metabolites of potent actinobacterial strains isolated from the Unkeshwar geothermal springs in India

Gajanan T. Mehetre, Vinodh J. S., Bhushan B. Burkul, D. Desai, Santhakumari B, Mahesh S. Dharne and Syed G. Dastager

RSC Adv., 2019, 9, 9850
DOI: 10.1039/C8RA09449G

Synthesis of C14–C21 acid fragments of cytochalasin Z8via anti-selective aldol condensation and B-alkyl Suzuki–Miyaura cross-coupling

Weiwei Han

RSC Adv., 2018, 8, 3899
DOI: 10.1039/C7RA13391J

Two Dibenzoquinones from the Fungus Acremonium cavaraeanum

Qiao Xu, Miao-Miao Zhang, Shu-Zhen Yana, Lu-Fen Cao, Qiang Lia, Jie Lin and Shuang-Lin Chen

Natural Product Communications, 2017, 12
DOI: 10.1177/1934578X1701201129

Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

Mengyu Sun, Dongdong Zhou, Jingwan Wu, Jing Zhou and Jing Xu

Marine Drugs, 2022, 20, 125
DOI: 10.3390/md20020125

Highly oxygenated chromones from mangrove-derived endophytic fungus Rhytidhysteron rufulum

Supichar Chokpaiboon, Siwattra Choodej, Nattawut Boonyuen, Thapong Teerawatananond and Khanitha Pudhom

Phytochemistry, 2016, 122, 172
DOI: 10.1016/j.phytochem.2015.12.010

Fungi as a Potential Source of Polyketides: A Review

A. Khajuria and S. Nonzom

Appl Biochem Microbiol, 2024, 60, 554
DOI: 10.1134/S0003683823603451

Integrating Activity-Guided Strategy and Fingerprint Analysis to Target Potent Cytotoxic Brefeldin A from a Fungal Library of the Medicinal Mangrove Acanthus ilicifolius

Cui-Fang Wang, Jie Ma, Qian-Qian Jing, Xi-Zhen Cao, Lu Chen, Rong Chao, Ji-Yong Zheng, Chang-Lun Shao, Xiao-Xi He and Mei-Yan Wei

Marine Drugs, 2022, 20, 432
DOI: 10.3390/md20070432

New polyketides from the mangrove-associated endophytic fungus Phomopsis sp. DHS-11

Zhi-Kai Guo, Bi-Ting Chen, Dan-Dan Chen, Xiao-Ling Deng and Jing Xu

Journal of Asian Natural Products Research, 2025, 1
DOI: 10.1080/10286020.2025.2482069

Anti-inflammatory cyclopropanes and benzofurans from mangrove endophytic fungus Schizophyllum sp. QYM-12

Tao Chen, Bing Sun, Xingze Hu, Yanghui Ou, Jianying Wu, Tingshun Zhu, Hongliang Yao and Zhigang She

Phytochemistry, 2025, 240, 114611
DOI: 10.1016/j.phytochem.2025.114611

Three new eudesmane-type sesquiterpenoids from the mangrove-derived endophytic fungus Penicillium sp. J-54

Huiqin Chen, Liuming Qiu, Pei Wang, Caihong Cai, Hao Wang, Haofu Dai and Wenli Mei

Phytochemistry Letters, 2019, 33, 36
DOI: 10.1016/j.phytol.2019.07.005

Immunosuppressive Cytochalasins from the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48

Zhao Feng, Xuexia Zhang, Jingwan Wu, Chengwen Wei, Ting Feng, Dongdong Zhou, Zhenchang Wen and Jing Xu

Marine Drugs, 2022, 20, 526
DOI: 10.3390/md20080526

Two new isocoumarins isolated from a mangrove-derived Penicillium sp.

Yu-Man Gan, Jia-Lang Xia, Long-Yan Zhao, Kai Liu, Zhen-Zhou Tang, Bing-Yao Huang, Yong-Hong Liu, Cheng-Hai Gao and Meng Bai

Phytochemistry Letters, 2022, 50, 21
DOI: 10.1016/j.phytol.2022.04.011

Bioactive components of endophytic fungi from two Hainan mangrove plants

Biting CHEN, Weicheng WU, Dongdong ZHOU, Xiaolin DENG, Shiqing ZHANG, Jingzhe YUAN, Jing XU and Zhikai GUO

JSUSU, 2022, 39, 245
DOI: 10.3724/SP.J.1249.2022.03245

New prenylated indole diketopiperazine alkaloids and polyketides from the mangrove-derived fungus Penicillium sp

Ruiyun Huo, Jinxin Zhang, Shubin Niu and Ling Liu

Front. Mar. Sci., 2022, 9
DOI: 10.3389/fmars.2022.1097594

Dicerandrol C Suppresses Proliferation and Induces Apoptosis of HepG2 and Hela Cancer Cells by Inhibiting Wnt/β-Catenin Signaling Pathway

Dongdong Zhou, Dandan Chen, Jingwan Wu, Ting Feng, Pinghuai Liu and Jing Xu

Marine Drugs, 2024, 22, 278
DOI: 10.3390/md22060278

Isolation and Antibiotic Screening of Fungi from a Hydrothermal Vent Site and Characterization of Secondary Metabolites from a Penicillium Isolate

Chengqian Pan, Yutong Shi, Bibi Nazia Auckloo, Syed Shams ul Hassan, Najeeb Akhter, Kuiwu Wang, Ying Ye, Chen-Tung Arthur Chen, Xinyi Tao and Bin Wu

Mar Biotechnol, 2017, 19, 469
DOI: 10.1007/s10126-017-9765-5

Anti-infectives from mangrove endophytic fungi

Sunil K. Deshmukh, Shivankar Agrawal, Ved Prakash, Manish K. Gupta and M. Sudhakara Reddy

South African Journal of Botany, 2020, 134, 237
DOI: 10.1016/j.sajb.2020.01.006

New Furan Derivatives from a Mangrove-Derived Endophytic Fungus Coriolopsis sp. J5

Liang-Liang Chen, Pei Wang, Hui-Qin Chen, Zhi-Kai Guo, Hao Wang, Hao-Fu Dai and Wen-Li Mei

Molecules, 2017, 22, 261
DOI: 10.3390/molecules22020261

Cytotoxic tetronic acid derivatives from the mangrove endophytic fungus Hypomontagnella monticulosa YX702

Yuxi Huang, Zanhong Chen, Meiying Huang, Kaixin Chen, Haisheng Liu, Juewen Liang, Yuting Liao, Jiayi Li, Liping Zhu, Bo Ding, Hongbo Huang and Yiwen Tao

Fitoterapia, 2023, 170, 105656
DOI: 10.1016/j.fitote.2023.105656

Diaporlabanoids A–C, Immunosuppressive Dinorlabdane Diterpene Alkaloids with an Unprecedented Carbon Skeleton from Mangrove Endophytic Fungus Diaporthe phaseolorum H3-2

Ting Feng, Xiaolin Deng, Zhiyong Xu and Jing Xu

Org. Lett., 2025, 27, 7267
DOI: 10.1021/acs.orglett.5c01572

Discovery of new bianthrones and chlorinated bianthrones with cytotoxic activity against cancer cells from Penicillium hispanicum guided by HSQC-based DeepSAT

Ruiyun Huo, Minhui Ji, Gaoran Liu and Ling Liu

Mycology, 2026, 17
DOI: 10.1080/21501203.2025.2526766

Chemical constituents of the mangrove-associated fungus Capnodium sp. SZ-F22. A new eremophilane sesquiterpene

Haibing He, Zhongjun Ma, Qianqian Wang, Yu Liu and Hualin Xu

Natural Product Research, 2016, 30, 1526
DOI: 10.1080/14786419.2015.1116000

Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis

Kunlong Li, Siqiang Chen, Xiaoyan Pang, Jian Cai, Xinya Zhang, Yonghong Liu, Yiguang Zhu and Xuefeng Zhou

European Journal of Medicinal Chemistry, 2022, 230, 114117
DOI: 10.1016/j.ejmech.2022.114117

Mangrove soil-derived Streptomyces: an important resource of pharmaceutical active natural products

Xuefeng ZHOU

Journal of Holistic Integrative Pharmacy, 2022, 3, 300
DOI: 10.1016/S2707-3688(23)00050-X

Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses

Meng-Jun Wu, Baofu Xu and Yue-Wei Guo

Marine Drugs, 2022, 20, 535
DOI: 10.3390/md20080535

Isochromophilones A–F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp. SCSIO 41011

Xiaowei Luo, Xiuping Lin, Huaming Tao, Junfeng Wang, Jiayi Li, Bin Yang, Xuefeng Zhou and Yonghong Liu

J. Nat. Prod., 2018, 81, 934
DOI: 10.1021/acs.jnatprod.7b01053

Two new 2,5-diketopiperazine derivatives from mangrove-derived endophytic fungus Nigrospora camelliae-sinensis S30

Dan-Yu Huang, Xu-Hua Nong, Yu-Qin Zhang, Wei Xu, Long-Yu Sun, Tao Zhang, Guang-Ying Chen and Chang-Ri Han

Natural Product Research, 2022, 36, 3651
DOI: 10.1080/14786419.2021.1878168

“Hyphae Intertwined, Biomolecules Co-Born”—New Polyketides Induction by Co-Culture of the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48 and Pestalotiopsis sp. HHL-101 at Both Volatile and Non-Volatile Levels

Ting Feng, Xiaojing Li, Zhenyi Liang and Jing Xu

Marine Drugs, 2025, 23, 452
DOI: 10.3390/md23120452

Oxygen-bridged cyclooctadienes and other polyketides from the mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1

Yihao Yin, Tao Chen, Bing Sun, Jiehui Li, Zhigang She, Guping Hu and Bo Wang

Journal of Molecular Structure, 2024, 1302, 137534
DOI: 10.1016/j.molstruc.2024.137534

Bioactive Polyketides From the Mangrove Endophytic Fungus Cytospora Rhizophorae SCNU‐F0054

Zirong Lin, Chunmei Chen, Zhe Zhou, Jialin Li and Yuhua Long

Chemistry & Biodiversity, 2026, 23
DOI: 10.1002/cbdv.71166

A new antimicrobial sesquiterpene isolated from endophytic fungus Cytospora sp. from the Chinese mangrove plant Ceriops tagal

Qin Deng, Gang Li, Mengyu Sun, Xiaobo Yang and Jing Xu

Natural Product Research, 2020, 34, 1404
DOI: 10.1080/14786419.2018.1512993

Isolation and molecular characterization of antifungal metabolite producing actinomycete from mangrove soil

Mary Sulakshana Palla, Girija Shankar Guntuku, Murali Krishna Kumar Muthyala, Sirisha Pingali and Prafulla Kumar Sahu

Beni-Suef University Journal of Basic and Applied Sciences, 2018, 7, 250
DOI: 10.1016/j.bjbas.2018.02.006

Diversified Polyketides and Nitrogenous Compounds from the Mangrove Endophytic Fungus Penicillium steckiiSCSIO 41025

Chun‐Mei Chen, Wei‐Hao Chen, Hua‐Ming Tao, Bin Yang, Xue‐Feng Zhou, Xiao‐Wei Luo and Yong‐Hong Liu

Chin. J. Chem., 2021, 39, 2132
DOI: 10.1002/cjoc.202100226

Halophytes-associated endophytic and rhizospheric bacteria: diversity, antagonism and metabolite production

Fehmida Bibi, Gary Allan Strobel, Muhammad Imran Naseer, Muhammad Yasir, Ahmed Abdullah Khalaf Al-Ghamdi and Esam Ibrahim Azhar

Biocontrol Science and Technology, 2018, 28, 192
DOI: 10.1080/09583157.2018.1434868

Chemical Investigation Of Secondary Metabolites Produced By Mangrove Endophytic Fungus Phyllosticta Capitalensis

Zhiyong Xu, Bingxue Xiong and Jing Xu

Natural Product Research, 2021, 35, 1561
DOI: 10.1080/14786419.2019.1656624

Efficient mining of natural products from Mangrove streptomyces using NP-PRESS

Lin Yu, Junxiao Wang, Kai Jin, Fan Xu, Yi Huang, Ran Zhang, Yihan Wu and Fei Xu

Arch Microbiol, 2025, 207
DOI: 10.1007/s00203-025-04380-6

Gas Chromatography–Mass Spectrometry Analysis of Artemisia judaica Methanolic Extract: Chemical Composition, Radical Scavenging Potential, Bioherbicidal Activity, and Dengue Vector Control

Naimah Asid H. Alanazi, Amani Alhejely, Sultan Mohammed Areshi, Hanan K. Alghibiwi, Samiah A. Alhabardi, Mohammed A. Akeel, Amal Naif Alshammari, Sarah Mohammed Alrajeh, Gadah A. Al-Hamoud and Salama A. Salama

IJMS, 2025, 26, 7355
DOI: 10.3390/ijms26157355

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

Loh Teng‐Hern Tan, Camille Keisha Mahendra, Yoon‐Yen Yow, Kok‐Gan Chan, Tahir Mehmood Khan, Learn‐Han Lee and Bey‐Hing Goh

MicrobiologyOpen, 2019, 8
DOI: 10.1002/mbo3.859

Dicitrinols A–C: Citrinin Derivatives from Hydrothermal Vent-Associated Fungus Penicillium citrinum TW132-59

Jihua Wei, Xuexia Chen and Bin Wu

J. Org. Chem., 2024, 89, 15264
DOI: 10.1021/acs.joc.4c02067

α-Glucosidase Inhibitors from Two Mangrove-Derived Actinomycetes

Xuejun Lu, Manlai Zhang, Yixian Qiu, Xiuxiu Liu, Cancan Wang, Jianwei Chen, Huawei Zhang, Bin Wei, Yanlei Yu, Youmin Ying, Kui Hong and Hong Wang

Molecules, 2023, 28, 3822
DOI: 10.3390/molecules28093822

Secondary Metabolites from the Mangrove-derived Fungus Trichoderma sp.

Guangrong Zi, Ying Shi, Kui Hong and Ling Liu

NPJ, 2025, 15
DOI: 10.2174/0122103155311374240517062929

ChemInform Abstract: Bioactive Natural Products Derived from Mangrove‐Associated Microbes

Jing Xu

ChemInform, 2015, 46
DOI: 10.1002/chin.201512314

Phylogenetic Diversity, Antimicrobial and Antioxidant Potential and Identification of Bioactive Compounds from Culturable Endophytic Fungi Associated with Mangrove Bruguiera sexangula (Lour.) Poir.

Xu Zhang, Zhiyong Xu, Jiankun Ma, Dongdong Zhou and Jing Xu

Curr Microbiol, 2021, 78, 479
DOI: 10.1007/s00284-020-02314-7

Identification of bioactive metabolites and evaluation of in vitro anti-inflammatory and in vivo antinociceptive and antiarthritic activities of endophyte fungi isolated from Elaeocarpus floribundus blume

Kishor Mazumder, Yasmeen Nazim Ruma, Rasheda Akter, Asma Aktar, Mir Monir Hossain, Zinnat Shahina, Santosh Mazumdar and Philip G. Kerr

Journal of Ethnopharmacology, 2021, 273, 113975
DOI: 10.1016/j.jep.2021.113975

The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2

Yihao Yin, Qi Tan, Jianying Wu, Tao Chen, Wencong Yang, Zhigang She and Bo Wang

Marine Drugs, 2023, 21, 566
DOI: 10.3390/md21110566

Two New Anthraquinones from the Marine-Derived Fungus Fusarium sp. J3-2

Min Chen, Jin-Tao Wu, Bao-Cong Hao, Cui-Li Jin, Li Shen, Cai-Juan Zheng, Li-Kui Zhang and Xiao-Jian Zhou

Chem Nat Compd, 2023, 59, 237
DOI: 10.1007/s10600-023-03965-1

Study on the Secondary Metabolites of Endophytic Penicillium sclerotiorum HLL113

Jing-Yu Yang, Min-Min Tang, Li Chen, Xin-Yi Lai, Xin Zhuo, Xue-Ming Zhou and Guang-Ying Chen

Chinese Journal of Organic Chemistry, 2022, 42, 896
DOI: 10.6023/cjoc202109021

Statistical approach to evaluate effect of temperature and moisture content on the production of antioxidant naphtho-gamma-pyrones and hydroxycinnamic acids by Aspergillus tubingensis in solid-state fermentation

Quentin Carboué, Catherine Rébufa, Rayhane Hamrouni, Sevastianos Roussos and Isabelle Bombarda

Bioprocess Biosyst Eng, 2020, 43, 2283
DOI: 10.1007/s00449-020-02413-6

Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens

Pragya Tiwari, Shreya Thakkar and Laurent Dufossé

Critical Reviews in Biotechnology, 2025, 45, 164
DOI: 10.1080/07388551.2024.2342979

Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362

Huawei Lv, Haibo Su, Yaxin Xue, Jia Jia, Hongkai Bi, Shoubao Wang, Jinkun Zhang, Mengdi Zhu, Mahmoud Emam, Hong Wang, Kui Hong and Xing-Nuo Li

Mar Life Sci Technol, 2023, 5, 232
DOI: 10.1007/s42995-023-00170-5

Antifungal Secondary Metabolites Isolated from Mangrove Rhizosphere Soil-Derived Penicillium Fungi

Nanxing Shen, Zhaoyang Liang, Qing Liu, Chuandeng Tu, Kunming Dong, Changyun Wang and Min Chen

J. Ocean Univ. China, 2020, 19, 717
DOI: 10.1007/s11802-020-4360-1

Microbial Metabolites Beneficial to Plant Hosts Across Ecosystems

Vartika Mathur and Dana Ulanova

Microb Ecol, 2023, 86, 25
DOI: 10.1007/s00248-022-02073-x

Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf

Bo Peng, Jian Cai, Zimin Xiao, Manli Liu, Xinlong Li, Bin Yang, Wei Fang, Yi-You Huang, Chunmei Chen, Xuefeng Zhou and Huaming Tao

Marine Drugs, 2023, 21, 327
DOI: 10.3390/md21060327

Cyclohexenoneterpenes A−J: Cytotoxic meroterpenoids from mangrove-associated fungus Penicillium sp. N-5

Tao Chen, Yufeng Liu, Yun Huang, Wencong Yang, Bing Sun, Qi Tan, Tianyu Wei, Bo Wang, Jie Yuan and Zhigang She

Phytochemistry, 2023, 215, 113868
DOI: 10.1016/j.phytochem.2023.113868

Natural Products from Diaporthe arecae with Anti‐Angiogenic Activity

Fang‐Rong Chang, Shih‐Wei Wang, Chi‐Ying Li, Yen‐Yi Lu, Shang‐Yin Vanson Liu, Ching‐Yeu Chen, Yang‐Chang Wu and Yuan‐Bin Cheng

Israel Journal of Chemistry, 2019, 59, 439
DOI: 10.1002/ijch.201800158

Bioactive Secondary Metabolites from Endophytic Fungi

Elena Ancheeva, Georgios Daletos and Peter Proksch

CMC, 2020, 27, 1836
DOI: 10.2174/0929867326666190916144709

Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungus Alternaria longipes

Gaoran Liu, Shubin Niu and Ling Liu

J Antibiot, 2021, 74, 152
DOI: 10.1038/s41429-020-00364-4

Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis

Shuai Liu, Yuping Zhao, Christian Heering, Christoph Janiak, Werner E. G. Müller, Sergi Hervé Akoné, Zhen Liu and Peter Proksch

J. Nat. Prod., 2019, 82, 1055
DOI: 10.1021/acs.jnatprod.8b00938

Isolation and Neuroprotective Activity of Phenolic Derivatives from the Marine-Derived Fungus Penicillium janthinellum

Yaoyao Zheng, Xu Chen, Lumin Chen, Li Shen, Xiumei Fu, Qiuxia Chen, Min Chen and Changyun Wang

J. Ocean Univ. China, 2020, 19, 700
DOI: 10.1007/s11802-020-4286-7

Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a Marine Algal–Derived Endophytic Fungus Aspergillus sp.

Sidhartha Taritla, Madhuree Kumari, Siya Kamat, Sarita G. Bhat and C. Jayabaskaran

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.542891

Citrinin Monomer, Trimer, and Tetracyclic Alkaloid Derivatives from the Hydrothermal Vent-Associated Fungus Penicillium citrinum TW132-59

Jihua Wei, Xuexia Chen, Yichao Ge, Qizhao Yin, Xiaodan Wu, Jinshan Tang, Zunjing Zhang and Bin Wu

J. Org. Chem., 2022, 87, 13270
DOI: 10.1021/acs.joc.2c01856

Induction of Three New Secondary Metabolites by the Co-Culture of Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11 Isolated from the Chinese Mangrove Plant Rhizophora mangle

Jingwan Wu, Jingjing Ye, Juren Cen, Yuanjie Chen and Jing Xu

Marine Drugs, 2024, 22, 332
DOI: 10.3390/md22080332

Diaporisoindoles A–C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp. SYSU-HQ3

Hui Cui, Yun Lin, Mingchu Luo, Yongjun Lu, Xishan Huang and Zhigang She

Org. Lett., 2017, 19, 5621
DOI: 10.1021/acs.orglett.7b02748

New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Bolin Hou, Sushi Liu, Ruiyun Huo, Yueqian Li, Jinwei Ren, Wenzhao Wang, Tao Wei, Xuejun Jiang, Wenbing Yin, Hongwei Liu, Ling Liu and Erwei Li

Marine Drugs, 2021, 19, 362
DOI: 10.3390/md19070362

Two new polyketides from endophytic fungus Pestalotiopsis sp. HQD-6 isolated from the Chinese mangrove plant Rhizophora mucronata

Jing Zhou, Dong-Yao Zheng and Jing Xu

Journal of Asian Natural Products Research, 2022, 24, 52
DOI: 10.1080/10286020.2021.1877674

Peniisocoumarins A–J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel

Runlin Cai, Yingnan Wu, Senhua Chen, Hui Cui, Zhaoming Liu, Chunyuan Li and Zhigang She

J. Nat. Prod., 2018, 81, 1376
DOI: 10.1021/acs.jnatprod.7b01018

Integrating Taxonomic and Chemical Diversity of Mangrove-Associated Ascomycetes to Discover or Repurpose Bioactive Natural Products

Ingrid Y. Martínez-Aldino, José Rivera-Chávez and Jesús Morales-Jiménez

J. Nat. Prod., 2023, 86, 2423
DOI: 10.1021/acs.jnatprod.3c00490

Discovery of Enzyme Inhibitors from Mangrove Sediment Derived Fungus Trichoderma harzianum SCSIO 41051

Lishan Huang, Chunmei Chen, Jian Cai, Yixin Chen, Yongyan Zhu, Bin Yang, Xuefeng Zhou, Yonghong Liu and Huaming Tao

Chemistry & Biodiversity, 2024, 21
DOI: 10.1002/cbdv.202400070

Investigation of the mechanisms involved in the biocontrol activities of natural products from a marine soil bacterium against rice blast

Liwang Fei, Rahila Hafeez, Junliang Zhang, Shiquan Fu, Ying Xu and Lingyun Hao

Pest Management Science, 2025, 81, 3122
DOI: 10.1002/ps.8684

Evaluation of the antimicrobial and cytotoxic potential of endophytic fungi extracts from mangrove plants Rhizophora stylosa and R. mucronata

Jing Zhou, Zhao Feng, Wenfang Zhang and Jing Xu

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-06711-9

Diversity and Taxonomy of Soil Bacterial Communities in Urban and Rural Mangrove Forests of the Panama Bay

Indira J. Quintero, Anakena M. Castillo and Luis C. Mejía

Microorganisms, 2022, 10, 2191
DOI: 10.3390/microorganisms10112191

Isolation of Cellulolytic Bacillus sp. from the Viviparous Seedling Hypocotyls of Red Mangrove – Rhizophora mucronata Lam.

K. Nidhina, R.M. Ayshommabi and Tomson Mani

J. Pure Appl. Microbiol., 2024, 18, 1515
DOI: 10.22207/JPAM.18.3.35

Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101

Zhiyong Xu, Xi Wu, Gang Li, Zhao Feng and Jing Xu

Natural Product Research, 2020, 34, 1002
DOI: 10.1080/14786419.2018.1539980

The culturable mycobiota of a Mediterranean marine site after an oil spill: isolation, identification and potential application in bioremediation

Elena Bovio, Giorgio Gnavi, Valeria Prigione, Federica Spina, Renata Denaro, Michail Yakimov, Rosario Calogero, Francesca Crisafi and Giovanna Cristina Varese

Science of The Total Environment, 2017, 576, 310
DOI: 10.1016/j.scitotenv.2016.10.064

New Naphthalene Derivatives from the Mangrove Endophytic Fungus Daldinia eschscholzii MCZ-18

Zhiyong Xu, Ting Feng, Zhenchang Wen, Qing Li, Biting Chen, Pinghuai Liu and Jing Xu

Marine Drugs, 2024, 22, 242
DOI: 10.3390/md22060242

Antioxidative Indenone and Benzophenone Derivatives from the Mangrove-Derived Fungus Cytospora heveae NSHSJ-2

Ge Zou, Taobo Li, Wencong Yang, Bing Sun, Yan Chen, Bo Wang, Yanghui Ou, Huijuan Yu and Zhigang She

Marine Drugs, 2023, 21, 181
DOI: 10.3390/md21030181

Total Synthesis of Thiocladospolide A and Its C2-Epimer

Pramod Swami, Maruti Mali, Baswaraj Dhulshette and Subhash Ghosh

Synthesis, 2022, 54, 683
DOI: 10.1055/a-1652-3714

Aspermeroterpenes A–C: Three Meroterpenoids from the Marine-Derived Fungus Aspergillus terreus GZU-31-1

Yuqian Tang, Yena Liu, Qingfeng Ruan, Min Zhao, Zhongxiang Zhao and Hui Cui

Org. Lett., 2020, 22, 1336
DOI: 10.1021/acs.orglett.9b04648

Occurrence and geographical distribution of mangrove fungi

B. Devadatha, E. B. G. Jones, K. L. Pang, M. A. Abdel-Wahab, K. D. Hyde, J. Sakayaroj, A. H. Bahkali, M. S. Calabon, V. V. Sarma, S. Sutreong and S. N. Zhang

Fungal Diversity, 2021, 106, 137
DOI: 10.1007/s13225-020-00468-0

Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential

Imran Shah, Zia Uddin, Maheer Hussain, Atif Ali Khan Khalil, Arshia Amin, Faisal Hanif, Liaqat Ali, Muhammad Imran Amirzada, Tawaf Ali Shah, Turki M. Dawoud, Mohammed Bourhia, Wen-Jun Li and Wasim Sajjad

BMC Microbiol, 2024, 24
DOI: 10.1186/s12866-024-03586-w

Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22

Zhao-Yang Liang, Nan-Xing Shen, Yao-Yao Zheng, Jin-Tao Wu, Li Miao, Xiu-Mei Fu, Min Chen and Chang-Yun Wang

Bioorganic Chemistry, 2019, 93, 103331
DOI: 10.1016/j.bioorg.2019.103331

Benzofuran Derivatives with Antimicrobial and Anti-Inflammatory Activities from Penicillium crustosum SCNU-F0046

Chen Chen, Jinbi Kang, Ruiqi Zhang, Hao Jia, Zirong Lin, Zhengming Liu, Rongrong Liu, Xinyi Zou and Yuhua Long

IJMS, 2025, 26, 7861
DOI: 10.3390/ijms26167861

Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances

Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe and Xuefeng Zhou

Marine Drugs, 2024, 22, 559
DOI: 10.3390/md22120559

Ophiobolin-Type Sesterterpenoids from the Mangrove Endophytic Fungus Aspergillus sp. ZJ-68

Runlin Cai, Hongming Jiang, Yaling Mo, Huixian Guo, Chunyuan Li, Yuhua Long, Zhenming Zang and Zhigang She

J. Nat. Prod., 2019, 82, 2268
DOI: 10.1021/acs.jnatprod.9b00462

Insights into the phylogenetic diversity, biological activities, and biosynthetic potential of mangrove rhizosphere Actinobacteria from Hainan Island

Jing-jing Ye, Ren-jian Zou, Dong-dong Zhou, Xiao-lin Deng, Ni-lin Wu, Dan-dan Chen and Jing Xu

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1157601

New Neuraminidase Inhibitory Alkaloids from the Mangrove Soil-Derived Fungus Arthrinium sp. SCSIO 41305

Yiwei Hu, Kai Zhao, Junheng Zhu, Xin Qi, Weihao Chen, Yingying Song, Xiaoyan Pang, Yonghong Liu and Junfeng Wang

J. Ocean Univ. China, 2023, 22, 1446
DOI: 10.1007/s11802-023-5439-2

Enhanced HCB removal using bacteria from mangrove as post-treatment after electrochemical oxidation using a laser-prepared Ti/RuO2–IrO2–TiO2 anode

Wanessa Jeane de Santana Mota, Gessica de Oliveira Santiago Santos, Aline Resende Dória, Michel Rubens dos Reis Souza, Laiza Canielas Krause, Giancarlo Richard Salazar-Banda, Katlin Ivon Barrios Eguiluz, Jorge A. López and María Lucila Hernández-Macedo

Chemosphere, 2021, 279, 130875
DOI: 10.1016/j.chemosphere.2021.130875

Epigenetic Manipulation Induced Production of Immunosuppressive Chromones and Cytochalasins from the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48

Ting Feng, Chengwen Wei, Xiaolin Deng, Dandan Chen, Zhenchang Wen and Jing Xu

Marine Drugs, 2022, 20, 616
DOI: 10.3390/md20100616

A New Phthalide Derivative from the Mangrove-Derived Fungus Eupenicillium sp. HJ002

Hai-Xia Liao, Xiao-Bao Li, Tai-Ming Shao and Zhang-Xin Yu

Chem Nat Compd, 2023, 59, 441
DOI: 10.1007/s10600-023-04019-2

Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp.

Chengwen Wei, Qin Deng, Mengyu Sun and Jing Xu

Molecules, 2020, 25, 4224
DOI: 10.3390/molecules25184224

Phaseolorin J Alleviates Cellular Inflammation and Oxidative Stress by Inhibiting NLRP3 Inflammasome Expression via the Nrf2/HO-1 Pathway

Yuanjie Chen, Ting Feng, Xiaojing Li, Jing Xu and Juren Cen

Marine Drugs, 2026, 24, 130
DOI: 10.3390/md24040130

Lead Compounds from Mangrove-Associated Microorganisms

Elena Ancheeva, Georgios Daletos and Peter Proksch

Marine Drugs, 2018, 16, 319
DOI: 10.3390/md16090319

Mangrove-Associated Fungi: A Novel Source of Potential Anticancer Compounds

Sunil K. Deshmukh, Manish K. Gupta, Ved Prakash and M. Sudhakara Reddy

JoF, 2018, 4, 101
DOI: 10.3390/jof4030101

Efophylins A and B, Two C2-Asymmetric Macrodiolide Immunosuppressants from Streptomyces malaysiensis

Jing Xu, Xuexia Zhang, Fanglu Huang, Gang Li and Peter F. Leadlay

J. Nat. Prod., 2021, 84, 1579
DOI: 10.1021/acs.jnatprod.1c00118

Two new α-Methoxy-γ-Pyrones From the Mangrove Sediment-Derived Streptomyces psammoticus SCSIO NS126

Kunlong Li, Mengdie Zhou, Ziqi Su, Xiliang Yang, Xuefeng Zhou, Jingxia Huang and Huaming Tao

Natural Product Communications, 2021, 16
DOI: 10.1177/1934578X211041420

New Naphtho-γ-Pyrones Isolated from Marine-Derived Fungus Penicillium sp. HK1-22 and Their Antimicrobial Activities

Yao-Yao Zheng, Zhao-Yang Liang, Nan-Xing Shen, Wen-Long Liu, Xiao-Jian Zhou, Xiu-Mei Fu, Min Chen and Chang-Yun Wang

Marine Drugs, 2019, 17, 322
DOI: 10.3390/md17060322

Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026

Xue Ren, Chunmei Chen, Yuxiu Ye, Ziying Xu, Qingliang Zhao, Xiaowei Luo, Yonghong Liu and Peng Guo

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.976399

Chevalierlin: A spirocyclic alkaloid from a hydrothermal vent associated fungus Aspergillus chevalieri TW132-65

Jihua Wei, Xuexia Chen, Yihan Ma and Bin Wu

Phytochemistry, 2025, 229, 114295
DOI: 10.1016/j.phytochem.2024.114295

Absolute configuration and anti-tumor activity of torrubiellin B

Catalina Francis Pérez Hemphill, Georgios Daletos, Alexandra Hamacher, Matthias Ullrich Kassack, Wenhan Lin, Attila Mándi, Tibor Kurtán and Peter Proksch

Tetrahedron Letters, 2015, 56, 4430
DOI: 10.1016/j.tetlet.2015.03.126

Microbial communication: A significant approach for new leads

M.A. Abdalla, S. Sulieman and L.J. McGaw

South African Journal of Botany, 2017, 113, 461
DOI: 10.1016/j.sajb.2017.10.001

Alkaloids from endophytic fungus Aspergillus fumigatus HQD24 isolated from the Chinese mangrove plant Rhizophora mucronata

Renjian Zou, Chengwen Wei, Xuexia Zhang, Dongdong Zhou and Jing Xu

Natural Product Research, 2022, 36, 5069
DOI: 10.1080/14786419.2021.1916017

Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants

Quentin Carboué, Marc Maresca, Gaëtan Herbette, Sevastianos Roussos, Rayhane Hamrouni and Isabelle Bombarda

Biomolecules, 2019, 10, 29
DOI: 10.3390/biom10010029

Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

Loh Teng-Hern Tan, Kok-Gan Chan, Chim Kei Chan, Tahir Mehmood Khan, Learn-Han Lee and Bey-Hing Goh

BioMed Research International, 2018, 2018, 1
DOI: 10.1155/2018/4823126

PyM Executes Immunosuppressive Activity on Murine T Lymphocytes via Inhibiting CN/NFAT Signaling Pathway

Xuexia Zhang, Xiaolin Deng, Xi Wu, Zhiyong Xu, Ting Feng and Jing Xu

MarineMedicine, 2025, 1, 31
DOI: 10.64187/mm.2025010103

Phenotypic and genomic characterization provide new insights into adaptation to environmental stressors and biotechnological relevance of mangrove Alcaligenes faecalis D334

Ngoc Tung Quach, Tran Thi Loan, Thi Thu An Nguyen, Thi Hanh Nguyen Vu, Quynh Anh Pham, Hoang Ha Chu, Quyet-Tien Phi and Doan Van Thuoc

Research in Microbiology, 2023, 174, 103994
DOI: 10.1016/j.resmic.2022.103994

Aromatic Polyketides from the Mangrove-Derived Streptomyces sp. SCSIO 40069

Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang and Qingbo Zhang

J. Nat. Prod., 2023, 86, 979
DOI: 10.1021/acs.jnatprod.2c01169

Four New Chromones from the Endophytic Fungus Phomopsis asparagi DHS-48 Isolated from the Chinese Mangrove Plant Rhizophora mangle

Chengwen Wei, Chunxiao Sun, Zhao Feng, Xuexia Zhang and Jing Xu

Marine Drugs, 2021, 19, 348
DOI: 10.3390/md19060348

New Polyene Macrolide Compounds from Mangrove-Derived Strain Streptomyces hiroshimensis GXIMD 06359: Isolation, Antifungal Activity, and Mechanism against Talaromyces marneffei

Zhou Wang, Jianglin Yin, Meng Bai, Jie Yang, Cuiping Jiang, Xiangxi Yi, Yonghong Liu and Chenghai Gao

Marine Drugs, 2024, 22, 38
DOI: 10.3390/md22010038

Secondary metabolites from the mangrove sediment-derived fungus Penicillium pinophilum SCAU037

Fei He, Xiaobao Li, Jin-Hai Yu, Xiaoyong Zhang, Xuhua Nong, Guangying Chen, Kongkai Zhu, Yin-Yin Wang, Jie Bao and Hua Zhang

Fitoterapia, 2019, 136, 104177
DOI: 10.1016/j.fitote.2019.104177

Phylogenetic diversity and antioxidant activities of culturable fungal endophytes associated with the mangrove species Rhizophora stylosa and R. mucronata in the South China Sea

Jing Zhou, Xiaoping Diao, Tao Wang, Guangying Chen, Qiang Lin, Xiaobo Yang, Jing Xu and Vijai Gupta

PLoS ONE, 2018, 13, e0197359
DOI: 10.1371/journal.pone.0197359

Advances in Natural Products from Mangrove-Associated Fungi Along the Indian Ocean Coast

Parakkrama Wijerathna, Xinqi Chen, Rongxiang Qiu, P.V.J.S. Wijethilake, Yi Chen, Nuwan Madushanka, I.J.J.U.N. Perera, Jian Cai, Lalith Jayasinghe, Yonghong Liu, Vajira P. Bulugahapitiya and Xuefeng Zhou

Molecules, 2026, 31, 261
DOI: 10.3390/molecules31020261

New Isocoumarin and Pyrone Derivatives from the Chinese Mangrove Plant Rhizophora mangle-Associated Fungus Phomopsis sp. DHS-11

Zhikai Guo, Biting Chen, Dandan Chen, Xiaoling Deng, Jingzhe Yuan, Shiqing Zhang, Zijun Xiong and Jing Xu

Molecules, 2023, 28, 3756
DOI: 10.3390/molecules28093756