Issue 20, 2023

19F NMR ON/OFF nanoparticles: a universal approach for the specific detection of DNA-binding cancer biomarkers

Abstract

A supramolecular approach for the design of assembly–disassembly-driven 19F ON/OFF nanoparticles, triggered by specific molecular recognition, for the detection of DNA binding cancer biomarkers is reported. The key to our design strategy is the characteristic 19F NMR signal of the probe, which completely vanishes in the aggregated state due to the shortening of T2 relaxation. However, molecular recognition of DNA by the cancer biomarkers through specific molecular recognition results in the disassembly of the nanoparticles, which causes the restoration of the characteristic 19F signal of the probe. The universal nature of the approach is demonstrated through the selective detection of various cancer biomarkers including miRNA, ATP, thrombin, and telomerase.

Graphical abstract: 19F NMR ON/OFF nanoparticles: a universal approach for the specific detection of DNA-binding cancer biomarkers

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar. 2023
Accepted
19 Api. 2023
First published
19 Api. 2023
This article is Open Access
Creative Commons BY license

Nanoscale, 2023,15, 8972-8977

19F NMR ON/OFF nanoparticles: a universal approach for the specific detection of DNA-binding cancer biomarkers

D. Perumal, J. Krishna, K. S. Harikrishnan, G. Raj, J. Kalathil, M. Saji, K. M. and R. Varghese, Nanoscale, 2023, 15, 8972 DOI: 10.1039/D3NR01175E

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