Issue 83, 2021

Selective synthesis of fluorinated biaryls by [MCl2(PhPEWO-F)] (M = Ni, Pd) catalysed Negishi cross-coupling

Abstract

Highly selective cross-couplings to polyfluorinated assymmetric biaryls, including the symmetric biaryl C6F5–C6F5, are achieved at relatively low temperature (80 °C) and in short times using [MCl2(PhPEWO-F)] catalysts (M = Ni, Pd; PhPEWO-F = 1-(PPh2), 2-(CH[double bond, length as m-dash]CH–C(O)Ph)–C6F4), ArFI, and Zn(C6F5)2 as example of highly fluorinated nucleophile.

Graphical abstract: Selective synthesis of fluorinated biaryls by [MCl2(PhPEWO-F)] (M = Ni, Pd) catalysed Negishi cross-coupling

Supplementary files

Article information

Article type
Communication
Submitted
01 Ira. 2021
Accepted
24 Ira. 2021
First published
27 Ira. 2021

Chem. Commun., 2021,57, 10875-10878

Selective synthesis of fluorinated biaryls by [MCl2(PhPEWO-F)] (M = Ni, Pd) catalysed Negishi cross-coupling

J. Ponce-de-León and P. Espinet, Chem. Commun., 2021, 57, 10875 DOI: 10.1039/D1CC04915A

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