Issue 38, 2022

Molecular partition coefficient from machine learning with polarization and entropy embedded atom-centered symmetry functions

Abstract

Efficient prediction of the partition coefficient (log P) between polar and non-polar phases could shorten the cycle of drug and materials design. In this work, a descriptor, named 〈q − ACSFs〉conf, is proposed to take the explicit polarization effects in the polar phase and the conformation ensemble of energetic and entropic significance in the non-polar phase into consideration. The polarization effects are involved by embedding the partial charge directly derived from force fields or quantum chemistry calculations into the atom-centered symmetry functions (ACSFs), together with the entropy effects, which are averaged according to the Boltzmann distribution of different conformations taken from the similarity matrix. The model was trained with high-dimensional neural networks (HDNNs) on a public dataset PhysProp (with 41 039 samples). Satisfactory log P prediction performance was achieved on three other datasets, namely, Martel (707 molecules), Star & Non-Star (266) and Huuskonen (1870). The present 〈q − ACSFs〉conf model was also applicable to n-carboxylic acids with the number of carbons ranging from 2 to 14 and 54 kinds of organic solvent. It is easy to apply the present method to arbitrary sized systems and give a transferable atom-based partition coefficient.

Graphical abstract: Molecular partition coefficient from machine learning with polarization and entropy embedded atom-centered symmetry functions

Supplementary files

Article information

Article type
Communication
Submitted
11 Eka. 2022
Accepted
23 Abu. 2022
First published
13 Ira. 2022

Phys. Chem. Chem. Phys., 2022,24, 23082-23088

Molecular partition coefficient from machine learning with polarization and entropy embedded atom-centered symmetry functions

Q. Zhu, Q. Jia, Z. Liu, Y. Ge, X. Gu, Z. Cui, M. Fan and J. Ma, Phys. Chem. Chem. Phys., 2022, 24, 23082 DOI: 10.1039/D2CP02648A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements