Single-cell lipidomics: protocol development for reliable cellular profiling using capillary sampling

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Analyst, 2025, 150, 1261
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Single-Cell Metabolomics-Based Strategy for Studying the Mechanisms of Drug Action

Guizhen Zhu, Wenmei Zhang, Yaoyao Zhao, Tian Chen, Hanyu Yuan, Yuanxing Liu, Guangsheng Guo, Zhihong Liu and Xiayan Wang

Anal. Chem., 2023, 95, 4712
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Exploring Single-Probe Single-Cell Mass Spectrometry: Current Trends and Future Directions

Deepti Bhusal, Shakya Wije Munige, Zongkai Peng and Zhibo Yang

Anal. Chem., 2025, 97, 4750
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True One Cell Chemical Analysis in Cancer Research: A Review

Karen Reyes and Guido F. Verbeck

J. Anal. Oncol., 2023, 12, 37
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Proteomics Analysis of Interactions between Drug-Resistant and Drug-Sensitive Cancer Cells: Comparative Studies of Monoculture and Coculture Cell Systems

Zongkai Peng, Nagib Ahsan and Zhibo Yang

J. Proteome Res., 2024, 23, 2608
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Reversal Drug Resistance of Tumor Cells by Manipulating its Membrane Heterogeneity through High Spatially Resolved Heating

Yusai Zhao, Xiaoqing Chen, Hengwei Zhang, Yifan Ge and Di Li

ACS Appl. Bio Mater., 2025, 8, 5291
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Multi Omics Applications in Biological Systems

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Concentric Hybrid Nanoelectrospray Ionization‐Atmospheric Pressure Chemical Ionization Source for High‐Coverage Mass Spectrometry Analysis of Single‐Cell Metabolomics

Tianrun Xu, Hang Li, Peng Dou, Yuanyuan Luo, Siming Pu, Hua Mu, Zhihao Zhang, Disheng Feng, Xuesen Hu, Ting Wang, Guang Tan, Chuang Chen, Haiyang Li, Xianzhe Shi, Chunxiu Hu and Guowang Xu

Advanced Science, 2024, 11
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Single-Cell Mass Spectrometry Studies of Secondary Drug Resistance of Tumor Cells

Guizhen Zhu, Wenmei Zhang, Yaoyao Zhao, Guangyun Wang, Hanyu Yuan, Guangsheng Guo and Xiayan Wang

Anal. Chem., 2025, 97, 337
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Developing a Cell Quenching Method to Facilitate Single Cell Mass Spectrometry Metabolomics Studies

Shakya Wije Munige, Deepti Bhusal, Zongkai Peng, Dan Chen and Zhibo Yang

JACS Au, 2025, 5, 2379
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Single-Cell Lipidomics Using Analytical Flow LC-MS Characterizes the Response to Chemotherapy in Cultured Pancreatic Cancer Cells

Kyle D. G. Saunders, Johanna von Gerichten, Holly-May Lewis, Priyanka Gupta, Matt Spick, Catia Costa, Eirini Velliou and Melanie J. Bailey

Anal. Chem., 2023, 95, 14727
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Mass spectrometry-based single-cell lipidomics: Advancements, challenges, and the path forward

Caitlin E. Randolph, Palak Manchanda, Harshit Arora, Sanjay Iyer, Pooja Saklani, Connor Beveridge and Gaurav Chopra

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MetaPhenotype: A Transferable Meta-Learning Model for Single-Cell Mass Spectrometry-Based Cell Phenotype Prediction Using Limited Number of Cells

Songyuan Yao, Tra D. Nguyen, Yunpeng Lan, Wen Yang, Dan Chen, Yihan Shao and Zhibo Yang

Anal. Chem., 2024, 96, 19238
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Microfluidic Sampling of Undissolved Components from Subcellular Regions of Living Single Cells for Mass Spectrometry Analysis

Qiang Zhang, Ling Lin, Xizhen Yi, Tianze Xie, Gaowa Xing, Yuxuan Li, Xiaorui Wang and Jin-Ming Lin

Anal. Chem., 2023, 95, 18082
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Development of a Single-Cell Spatial Metabolomics Method for the Characterization of Cell–Cell Metabolic Interactions

Yaqi Zhang, Panpan Chen, Haoyuan Geng, Min Li, Shiping Chen, Bangzhen Ma, Yan Ma, Jianjun Lai, Xiaoqing Cui, Wei Chong, Hao Chen, Xiao Wang and Chenglong Sun

Anal. Chem., 2025, 97, 7986
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Advances in Sampling and Analytical Techniques for Single‐Cell Metabolomics: Exploring Cellular Heterogeneity

Xinxin Shen, Fangyuan Zhang, Chunping Tang, Marina Soković, Danijela Mišić, Hongxi Xu, Yang Ye and Jia Liu

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Single-cell mass spectrometry studies of drug metabolism heterogeneity and primary resistance to gefitinib in non-small cell lung cancer cells

Guizhen Zhu, Yaoyao Zhao, Wenmei Zhang, Yuanyuan Wu, Yuanxing Liu, Guangsheng Guo, Xiayan Wang and Zhihong Liu

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Trends in Mass Spectrometry-Based Single-Cell Proteomics

Ximena Sanchez-Avila, Raphaela M. de Oliveira, Siqi Huang, Chao Wang and Ryan T. Kelly

Anal. Chem., 2025, 97, 5893
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Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging

Hua Zhang, Yuan Liu, Lauren Fields, Xudong Shi, Penghsuan Huang, Haiyan Lu, Andrew J. Schneider, Xindi Tang, Luigi Puglielli, Nathan V. Welham and Lingjun Li

Nat Commun, 2023, 14
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High-throughput single-cell metabolites profiling reveals metabolic reprogramming confers cisplatin resistance in lung cancer

Changyi Liu, Siyuan Pan, Xingyu Pan, Jinlei Yang, Huan Yao, Zhenli Yang, Sijia Hao, Yuqin Liu, Peng Liu and Sichun Zhang

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Dynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages

Yi Zhang, Mingying Shi, Mingxuan Li, Shaojie Qin, Daiyu Miao and Yu Bai

Nat Commun, 2025, 16
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Pulled Flowprobe for Ambient Liquid Extraction-Based High Spatial Resolution Mass Spectrometry Imaging with Enhanced Sensitivity and Stability

Zhihao Zhao, Zheng Long, Huabei Wang, Qian Wu, Yang Wang and Hongmei Lu

Anal. Chem., 2023, 95, 16927
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Electrical Stimulation Increases the Secretion of Cardioprotective Extracellular Vesicles from Cardiac Mesenchymal Stem Cells

Haitao Zhang, Yan Shen, Il-man Kim, Yutao Liu, Jingwen Cai, Adam E. Berman, Kent R. Nilsson, Neal L. Weintraub and Yaoliang Tang