Base-controlled regio-divergent C–H bond functionalization

Yanlong Luo, Xi Chen, Yongfang Han, Xiangyun Zhang, Lixia Zhang, Zongqi Zheng, Wenzhuo Ma, Guolong Lou, Dongdong Huang, Jianlong Li and Hebin Wang

Chem. Commun., 2025, 61, 5688
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Alkali-amide controlled selective synthesis of 7-azaindole and 7-azaindoline through domino reactions of 2-fluoro-3-methylpyridine and aldehydes

Xinyu Xu, Mingjie Ou, Yan-En Wang, Tingzhi Lin, Dan Xiong, Fei Xue, Patrick J. Walsh and Jianyou Mao

Org. Chem. Front., 2022, 9, 2541
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C–H functionalization through benzylic deprotonation with π-coordination or cation–π-interactions

Hui Zhu(s), Yu Wu, Jianyou Mao, Jingkai Xu, Patrick J. Walsh and Hang Shi

Chem. Soc. Rev., 2025, 54, 2520
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Cation-controlled chemoselective synthesis of N-aroylureas and imides via amidation of N-Boc arylamides

Jiamin Wang, Sujuan Shuai, Lishe Gan, Yongxin Luo, Huimin Jin, Lingfeng Chen, Dong Zou, Guang Liang, Patrick J. Walsh and Jie Li

Org. Chem. Front., 2023, 10, 2061
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Process Development of a PI3Kδ Inhibitor: A Novel and Practical [1,2]-Boc Migration on Purine Rings

Tsuyoshi Ueda, Kei Kurahashi, Yoshio Nishi and Yutaka Kitagawa

Org. Process Res. Dev., 2025
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Substrate-Controlled Divergent Reductive Cyclization of 2-Arylanilines Using CO2 as a Switching Reagent

Qiang Yan, Jiang Nan, Rui Cao, Lanxin Zhu, Shilei Liu, Chengyuan Liang and Chen Zhang

Org. Lett., 2025, 27, 510
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Brønsted Base Prompted sp3 C–H Latent Nucleophiles to Access α-Branched Amines Bearing β-Carbonyl by Cleaving Amide and Ester Bonds

Ramdas Sreedharan and Thirumanavelan Gandhi

J. Org. Chem., 2023, 88, 8480
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Synthesis of α‐Aryl Ketones by Harnessing the Non‐Innocence of Toluene and its Derivatives: Enhancing the Acidity of Methyl Arenes by a Brønsted Base and their Mechanistic Aspects

Ramdas Sreedharan, Pradeep Kumar Pal, Pradeep Kumar Reddy Panyam, U. Deva Priyakumar and Thirumanavelan Gandhi

Asian J Org Chem, 2022, 11
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Iodine-Catalyzed Room-Temperature Aerobic Oxidation of C(sp3)–H Bonds and Its Application in the Synthesis of Quinoxaline Derivatives

Hanyu Xiong, Longxing Wang, Yuanyang Mu, Jiajun Li, Junbiao Chang and Wenquan Yu

J. Org. Chem., 2025, 90, 6362
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NaN(SiMe3)2/CsTFA Copromoted Aminobenzylation/Cyclization of 2-Isocyanobenzaldehydes with Toluene Derivatives or Benzyl Compounds: One-Pot Access to Dihydroquinazolines and Quinazolines

Xiang-He Meng, Xue-Cen Xu, Zhuo Wang, Yong-Xin Liang and Yu-Long Zhao

J. Org. Chem., 2022, 87, 3156
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Lateral Deprotometallation‐Trapping Reactions on Methylated Pyridines, Quinolines and Quinoxalines Using Lithium Diethylamide

Mohamed Hasyeoui, Peter M. Chapple, Frédéric Lassagne, Thierry Roisnel, Marie Cordier, Ali Samarat, Yann Sarazin and Florence Mongin

Eur J Org Chem, 2023, 26
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Rhodium‐Catalyzed Benzylic Addition Reactions of Alkylarenes to Michael Acceptors

Yuntong Li, Wen‐Qiang Wu, Hui Zhu, Qi‐Kai Kang, Lun Xu and Hang Shi

Angewandte Chemie, 2022, 134
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One-pot transition-metal-free synthesis of alkynes and enynes

Yuanyun Gu, Yu Wu, Yan-En Wang, Nidheesh Phadnis, Dan Xiong, Jianyou Mao and Patrick J. Walsh

Cell Reports Physical Science, 2024, 5, 102132
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Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System

Yuanyun Gu, Zhen Zhang, Yan-En Wang, Ziteng Dai, Yaqi Yuan, Dan Xiong, Jie Li, Patrick J. Walsh and Jianyou Mao

J. Org. Chem., 2022, 87, 406
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Base‐Promoted Tandem Synthesis of 6‐H‐Phenanthridine and its Derivatives

Haoyu Jin, Min Zeng, Shouliang Wang, Yitian Ding, Suyang Chen, Jinxi Feng, Xianhao Chen, Tingting Miao, Fen Wu and Qian Shi

Eur J Org Chem, 2025, 28
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Synthesis of Peptide N-Acylpyrroles via Anodically Generated N,O-Acetals

Yutong Lin and Lara R. Malins

Synthesis, 2022, 54, 3558
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Base-Promoted Tandem Synthesis of 3,4-Dihydroisoquinolones

Jie Li, Huan Wang, Huimin Jin, Zhenhua Xiang, Lingfeng Chen, Patrick J. Walsh and Guang Liang

Org. Lett., 2022, 24, 8125
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Synthesis of N-alkoxycarbonyl Pyrroles from O-Substituted Carbamates: A Synthetically Enabling Pyrrole Protection Strategy

Jodie L. Hann, Catherine L. Lyall, Gabriele Kociok-Köhn and Simon E. Lewis

J. Org. Chem., 2023, 88, 13584
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Masters of Mediation: MN(SiMe3)2 in Functionalization of C(sp3)−H Latent Nucleophiles

Ramdas Sreedharan and Thirumanavelan Gandhi

Chemistry A European J, 2024, 30
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Rhodium‐Catalyzed Benzylic Addition Reactions of Alkylarenes to Michael Acceptors

Yuntong Li, Wen‐Qiang Wu, Hui Zhu, Qi‐Kai Kang, Lun Xu and Hang Shi

Angew Chem Int Ed, 2022, 61
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Acid/Iodide Cooperative Catalysis for Highly Chemoselective Esterification of Unactivated Tertiary Amides via Electrophilic N−C(O) Activation

Chenglong Li, Qun Wang, Qihang Tan, Lei Yang, Long Liu, Tianzeng Huang, Michal Szostak and Tieqiao Chen

ACS Sustainable Chem. Eng., 2024, 12, 18624
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Research progress on transition-metal-free C–N bonds cleavage of amides in the synthesis of ketones

Yanlong Luo

Sci. Sin.-Chim, 2023, 53, 129
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Classes of Amides that Undergo Selective N–C Amide Bond Activation: The Emergence of Ground-State Destabilization

Pengcheng Gao, Md. Mahbubur Rahman, Alfredo Zamalloa, Jessica Feliciano and Michal Szostak

J. Org. Chem., 2023, 88, 13371
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Recent progress in remote γ-C(sp<sup>3</sup>)–H functionalization of carboxylic acid derivatives

Yueting Huang and Dong Zou

Sci. Sin.-Chim, 2023, 53, 932
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Base-Promoted Tandem Synthesis of Indolo[1,2-b]isoquinolines from 2-Alkynylaniline and Nitroarenes

Qingxia Zhao, Haojie Ge, Huimin Jin, Lingfeng Chen, Guang Liang, Patrick J. Walsh and Jie Li

J. Org. Chem., 2025
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Recent Progress in Benzylic C(sp3)—H Functionalization of Toluene and Its Derivatives

Chenyi Cai and Dong Zou

Chinese Journal of Organic Chemistry, 2022, 42, 1586
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