Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH

Anandhu Krishnan, Sodiq O. Waheed, Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J. Schofield and Tatyana G. Karabencheva-Christova

Chem. Sci., 2024, 15, 3466
DOI: 10.1039/D3SC05974J

Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5

Fathima Hameed Cherilakkudy, Midhun George Thomas, Ann Varghese, Sodiq O. Waheed, Anandhu Krishnan, Vincenzo Venditti, Christopher J. Schofield, Deyu Li, Christo Z. Christov and Tatyana G. Karabencheva-Christova

Cell Reports Physical Science, 2025, 6, 102779
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How Do Variants of Residues in the First Coordination Sphere, Second Coordination Sphere, and Remote Areas Influence the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate Dependent Ethylene-Forming Enzyme?

Midhun George Thomas, Simahudeen Bathir Jaber Sathik Rifayee and Christo Z. Christov

ACS Catal., 2024, 14, 18550
DOI: 10.1021/acscatal.4c04010

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz S. Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Sam P. de Visser and Anthony P. Green

ACS Catal., 2024, 14, 11584
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How Do Differences in Electronic Structure Affect the Use of Vanadium Intermediates as Mimics in Nonheme Iron Hydroxylases?

Vyshnavi Vennelakanti, Mugyeom Jeon and Heather J. Kulik

Inorg. Chem., 2024, 63, 4997
DOI: 10.1021/acs.inorgchem.3c04421

Revealing the catalytic strategy of FTO

Ann Varghese, Sodiq O. Waheed, Shobhit S. Chaturvedi, Isabella DiCastri, Ciara LaRouche, Brendan Kaski, Nicolai Lehnert, Deyu Li, Christo Z. Christov and Tatyana G. Karabencheva-Christova

Chem Catalysis, 2023, 3, 100732
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Comparison of Magnesium and Manganese Ions on the Structural and Catalytic Properties of Human DNA Polymerase Gamma

Arkanil Roy and G. Andrés Cisneros

J. Chem. Theory Comput., 2025
DOI: 10.1021/acs.jctc.5c00435

Origins of Catalysis in Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Histone Lysine Demethylase KDM4A with Differently Methylated Histone H3 Peptides

Sudheesh Devadas, Midhun George Thomas, Simahudeen Bathir Jaber Sathik Rifayee, Bhargav Varada, Walter White, Ethan Sommer, Kylin Campbell, Christopher J. Schofield and Christo Z. Christov

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202403989

What Drives Radical Halogenation versus Hydroxylation in Mononuclear Nonheme Iron Complexes? A Combined Experimental and Computational Study

Emilie F. Gérard, Vishal Yadav, David P. Goldberg and Sam P. de Visser

J. Am. Chem. Soc., 2022, 144, 10752
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Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Aspartyl Hydroxylase AspH

Anandhu Krishnan, Sodiq O. Waheed, Sreerag Melayikandy, Ciara LaRouche, Meredith Paik, Christopher J. Schofield and Tatyana G. Karabencheva‐Christova

ChemPhysChem, 2024, 25
DOI: 10.1002/cphc.202400303

Computational Investigation of the Role of Metal Center Identity in Cytochrome P450 Enzyme Model Reactivity

Vyshnavi Vennelakanti, Mugyeom Jeon and Heather J. Kulik

Biochemistry, 2025, 64, 678
DOI: 10.1021/acs.biochem.4c00594

Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition

Yazdan Maghsoud, Erik Antonio Vázquez-Montelongo, Xudong Yang, Chengwen Liu, Zhifeng Jing, Juhoon Lee, Matthew Harger, Ally K. Smith, Miguel Espinoza, Hou-Fu Guo, Jonathan M. Kurie, Kevin N. Dalby, Pengyu Ren and G. Andrés Cisneros

J. Chem. Inf. Model., 2023, 63, 986
DOI: 10.1021/acs.jcim.2c01448