Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue and Yosuke Demizu

RSC Med. Chem., 2024, 15, 3695
DOI: 10.1039/D4MD00546E

Investigations into linker effects of DNA–VHL ligand conjugates by multiplexed affinity measurements using focal molography

Pascal Raschke, Simona Notova, Volker Gatterdam, Andreas Frutiger and Andreas Brunschweiger

RSC Chem. Biol., 2026
DOI: 10.1039/D6CB00011H

A cocktail therapeutic strategy based on clofarabine-containing aptamer-PROTAC for enhanced cancer therapy

Zhenzhen Chen, Mohan Chen, Ran Liu, Huanhuan Fan and Jingjing Zhang

Chem. Commun., 2023, 59, 11560
DOI: 10.1039/D3CC02904B

PROTACs coupled with oligonucleotides to tackle the undruggable

Guangshuai Zhang, Si Yan, Yan Liu, Ziwei Du, Qin Min and Shuanglin Qin

Bioanalysis, 2025, 17, 261
DOI: 10.1080/17576180.2025.2459528

Design, synthesis, and biological evaluation of BRD4 degraders

Mengyuan Ding, Yingying Shao, Danwen Sun, Suorina Meng, Yi Zang, Yubo Zhou, Jia Li, Wei Lu and Shulei Zhu

Bioorganic & Medicinal Chemistry, 2023, 78, 117134
DOI: 10.1016/j.bmc.2022.117134

Bifunctional proximity-inducing strategies for targeted and programmable post-translational modifications

Sadiya Tanga, Pallabi Das, Tuhin Baran Samoi, Arpita Hota, Arkadeep Karmakar and Basudeb Maji

Advanced Drug Delivery Reviews, 2026, 115874
DOI: 10.1016/j.addr.2026.115874

Expanding the horizons of targeted protein degradation: A non-small molecule perspective

Xiaowei Huang, Fengbo Wu, Jing Ye, Lian Wang, Xiaoyun Wang, Xiang Li and Gu He

Acta Pharmaceutica Sinica B, 2024, 14, 2402
DOI: 10.1016/j.apsb.2024.01.010

Current advances of small molecule E3 ligands for proteolysis-targeting chimeras design

Dazhao Mi, Yuzhan Li, Haijun Gu, Yan Li and Yihua Chen

European Journal of Medicinal Chemistry, 2023, 256, 115444
DOI: 10.1016/j.ejmech.2023.115444

ARE-PROTACs Enable Co-degradation of an Nrf2–MafG Heterodimer

Jianai Ji, Sinan Ma, Yuxuan Zhu, Jinglong Zhao, Yuanyuan Tong, Qidong You and Zhengyu Jiang

J. Med. Chem., 2023, 66, 6070
DOI: 10.1021/acs.jmedchem.2c01909

State‐of‐the‐Art Nrf2 Inhibitors: Therapeutic Opportunities in Non‐Cancer Diseases

Emil G. Ayala‐Cosme, Deborah Yang, Kyara Vences, Lindsey O. Davis and Matteo Borgini

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400377

Nucleic-Acid-Based Targeted Degradation in Drug Discovery

Wei Wang, Shipeng He, Guoqiang Dong and Chunquan Sheng

J. Med. Chem., 2022, 65, 10217
DOI: 10.1021/acs.jmedchem.2c00875

Advancing targeted protein degradation for metabolic diseases therapy

Qian-Qian Zhou, Hai-Tao Xiao, Fan Yang, Yong-Dan Wang, Ping Li and Zu-Guo Zheng

Pharmacological Research, 2023, 188, 106627
DOI: 10.1016/j.phrs.2022.106627

PROTACs Targeting MLKL Protect Cells from Necroptosis

Oliver H. Rathje, Lara Perryman, Richard J. Payne and Dieter W. Hamprecht

J. Med. Chem., 2023, 66, 11216
DOI: 10.1021/acs.jmedchem.3c00665

Recent Advances in PROTAC Technology Toward New Therapeutic Modalities

Hidetomo Yokoo, Miyako Naganuma, Makoto Oba and Yosuke Demizu

Chemistry & Biodiversity, 2022, 19
DOI: 10.1002/cbdv.202200828

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

Jeremy Hall, Zhuoran Zhang, Supriyo Bhattacharya, Dongfang Wang, Marice Alcantara, Yong Liang, Piotr Swiderski, Stephen Forman, Larry Kwak, Nagarajan Vaidehi and Marcin Kortylewski

Molecular Therapy Nucleic Acids, 2024, 35, 102137
DOI: 10.1016/j.omtn.2024.102137

Advancing Strategies for Proteolysis-Targeting Chimera Design

Minglei Li, Ying Zhi, Bo Liu and Qingqiang Yao

J. Med. Chem., 2023, 66, 2308
DOI: 10.1021/acs.jmedchem.2c01555

Targeting bacterial degradation machinery as an antibacterial strategy

Radoslav Petkov, Amy H. Camp, Rivka L. Isaacson and James H. Torpey

Biochemical Journal, 2023, 480, 1719
DOI: 10.1042/BCJ20230191

Discovery and Characterization of PVTX-321 as a Potent and Orally Bioavailable Estrogen Receptor Degrader for ER+/HER2– Breast Cancer

Guozhang Xu, Courtney G. Havens, Qiaolin Deng, Cassandra Lowenstein, Debangshu Samanta, Brian Vidal, Elham Behshad, Mike Russell, Peter Orth, Cory T. Rice, Rakesh Nagilla, Paul Kirchhoff, Zhixiang Chen, Rohan Kalyan Rej, Ranjan Kumar Acharyya, Dimin Wu, Shaomeng Wang, Weihong Zhang, Wenxue Wu, Larry Jolivette, Corey Strickland, Zhihua Sui, Helai P. Mohammad, Xuqing Zhang and E. Scott Priestley

J. Med. Chem., 2025, 68, 11299
DOI: 10.1021/acs.jmedchem.5c00223