Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates

Tin Long Chris Ng, Mateo P. Hoare, M. Julia Maristany, Ellis J. Wilde, Tomas Sneideris, Jan Huertas, Belinda K. Agbetiameh, Mona Furukawa, Jerelle A. Joseph, Tuomas P. J. Knowles, Rosana Collepardo-Guevara, Laura S. Itzhaki and Janet R. Kumita

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Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex

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IJMS, 2021, 22, 4115
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Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition

Amanda M. Acevedo-Jake, Bram Mylemans, Danielle F. Kay, Peiyu Zhang, Boguslawa Korona, Guto G. Rhys, Aneika C. Leney, Danny T. Huang, Thomas A. Edwards, Laura Itzhaki, Derek N. Woolfson and Andrew J. Wilson

ACS Chem. Biol., 2025, 20, 1309
DOI: 10.1021/acschembio.5c00137

Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Jazmine P. Hallinan, Lindsey A. Doyle, Betty W. Shen, Mesfin M. Gewe, Brittany Takushi, Madison A. Kennedy, Della Friend, James M. Roberts, Philip Bradley and Barry L. Stoddard

Commun Biol, 2021, 4
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Engineered Repeat Protein Hybrids: The New Horizon for Biologic Medicines and Diagnostic Tools

Kepa B. Uribe, Eduardo Guisasola, Antonio Aires, Elena López-Martínez, Gabriela Guedes, Ivan R. Sasselli and Aitziber L. Cortajarena

Acc. Chem. Res., 2021, 54, 4166
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Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix

Marie Synakewicz, Rohan S. Eapen, Albert Perez-Riba, Pamela J. E. Rowling, Daniela Bauer, Andreas Weißl, Gerhard Fischer, Marko Hyvönen, Matthias Rief, Laura S. Itzhaki and Johannes Stigler

ACS Nano, 2022, 16, 3895
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Using a stable protein scaffold to display peptides that bind to alpha‐synuclein fibrils

Samuel Bismut, Matthias M. Schneider, Masashi Miyasaki, Yuqing Feng, Ellis J. Wilde, M. Dylan Gunawardena, Tuomas P. J. Knowles, Gabrielle S. Kaminski Schierle, Laura S. Itzhaki and Janet R. Kumita

Protein Science, 2025, 34
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Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1

Sarah K Madden, Laura S Itzhaki and Skerra Arne

Protein Engineering, Design and Selection, 2021, 34
DOI: 10.1093/protein/gzab027