Photoenzymatically-induced asymmetric hydroarylation of alkenes with (hetero)aryl halides†
Corey L.
Jones, 
a
Simon
Berritt,
a
Thomas
Knauber,
a
Scott P.
France,
‡a
Paul
Richardson,
b
Roger M.
Howard
*a
and
Hatice G.
Yayla
*a
a
Simon
Berritt,
a
Thomas
Knauber,
a
Scott P.
France,
‡a
Paul
Richardson,
b
Roger M.
Howard
*a
and
Hatice G.
Yayla
*a
Abstract
A set of stereocomplementary ene-reductase enzymes are described which, when induced by light and aided by an exogenous photocatalyst, catalyze the coupling of (hetero)aryl halides and alkenes in an asymmetric intermolecular hydroarylation process. Thus, carbon scaffolds containing C(sp2)–C(sp3) bonds are synthesized enzymatically from simple precursors in excellent enantiomeric excess. Furthermore, an intramolecular mode is presented with improved yield.
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