Issue 49, 2023

N-Alkylation of aromatic amines with alcohols by using a commercially available Ru complex under mild conditions

Abstract

An N-alkylation procedure has been developed under very mild conditions using a known commercially available Ru-based catalyst. As a result, a wide range of aromatic primary amines has been selectively alkylated with several primary alcohols, yielding the corresponding secondary amines in high yields. The methodology also enables the methylation of anilines in refluxing methanol and the preparation of a set of heterocycles in a straightforward way.

Graphical abstract: N-Alkylation of aromatic amines with alcohols by using a commercially available Ru complex under mild conditions

Supplementary files

Article information

Article type
Paper
Submitted
04 okt 2023
Accepted
09 nov 2023
First published
30 nov 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 34847-34851

N-Alkylation of aromatic amines with alcohols by using a commercially available Ru complex under mild conditions

R. Mocci, L. Atzori, W. Baratta, L. De Luca and A. Porcheddu, RSC Adv., 2023, 13, 34847 DOI: 10.1039/D3RA06751C

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