Issue 47, 2019

Hydrogenation and N-alkylation of anilines and imines via transfer hydrogenation with homogeneous nickel compounds

Abstract

The nickel-catalyzed N-alkylation of a variety of arylamines via transfer hydrogenation in the absence of pressurized hydrogen and basic or acidic additives was achieved in a tandem reaction. This process was further extended to the C[double bond, length as m-dash]N bond reduction and N-alkylation of a variety of imines with ethanol, the latter acting as a hydrogen and acetaldehyde source, which allowed for the reduction and subsequent condensation to yield the corresponding N-alkylated products.

Graphical abstract: Hydrogenation and N-alkylation of anilines and imines via transfer hydrogenation with homogeneous nickel compounds

Supplementary files

Article information

Article type
Paper
Submitted
21 okt 2019
Accepted
07 nov 2019
First published
08 nov 2019

Dalton Trans., 2019,48, 17579-17587

Hydrogenation and N-alkylation of anilines and imines via transfer hydrogenation with homogeneous nickel compounds

G. E. Benitez-Medina and J. J. García, Dalton Trans., 2019, 48, 17579 DOI: 10.1039/C9DT04111G

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