Issue 10, 2012
From the journal:

Organic & Biomolecular Chemistry

Conformational stability of collagen triple helices functionalized in the Yaa position by click chemistry†‡

Roman S. Erdmannab  and  Helma Wennemers*ab  

* Corresponding authors

a Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland

b Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland
E-mail: helma.wennemers@org.chem.ethz.ch

Abstract

Click chemistry was used to introduce moieties as sterically demanding as monosaccharides into the Yaa position of collagen model peptides. The effect of different triazolyl derivatives as well as the configuration of the functionalized proline residue on the thermal stability of the collagen triple helices was examined.

Graphical abstract: Conformational stability of collagen triple helices functionalized in the Yaa position by click chemistry

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Article information

DOI
https://doi.org/10.1039/C2OB06720J
Article type
Paper
Submitted
11 Oct 2011
Accepted
07 Dec 2011
First published
20 Jan 2012

Org. Biomol. Chem., 2012,10, 1982-1986

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Conformational stability of collagen triple helices functionalized in the Yaa position by click chemistry

R. S. Erdmann and H. Wennemers, Org. Biomol. Chem., 2012, 10, 1982 DOI: 10.1039/C2OB06720J

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