Themed collection Food & Function HOT Articles 2025

41 items
Review Article

Molecular mechanisms of aberrant fatty acids metabolism in driving cardiovascular diseases: key regulatory targets and dietary interventions

Aberrant fatty acid metabolism promotes cardiovascular disease via oxidative stress, inflammation, and vascular dysfunction. Targeting key pathways and optimizing lipid intake offers promising strategies for prevention and treatment.

Graphical abstract: Molecular mechanisms of aberrant fatty acids metabolism in driving cardiovascular diseases: key regulatory targets and dietary interventions
From the themed collection: Food & Function Review Articles 2025
Open Access Review Article

Polysaccharides from echinoderms: unlocking health benefits and food applications – a review

Polysaccharides from echinoderms show diverse structures with unique functional properties. Their bioactivities including anti-inflammatory, antioxidant and anticoagulant effects, highlight their potential in health and functional food applications.

Graphical abstract: Polysaccharides from echinoderms: unlocking health benefits and food applications – a review
From the themed collection: Food & Function HOT Articles 2025
Review Article

Dietary strategies for appetite regulation: satiety and obesity management

Different nutrients and metabolites affect appetite signals and the feed desire.

Graphical abstract: Dietary strategies for appetite regulation: satiety and obesity management
From the themed collection: Food & Function HOT Articles 2025
Review Article

Biomarkers of fried food intake: a systematic review of in vivo studies

In vivo studies disclose biomarkers of fried food intake, via MS-based metabolomics.

Graphical abstract: Biomarkers of fried food intake: a systematic review of in vivo studies
From the themed collection: Food & Function HOT Articles 2025
Review Article

The interaction between starch and phenolic acids: effects on starch physicochemical properties, digestibility and phenolic acids stability

Starch and phenolic acids, two common plant-based food components, can interact to form complexes during food processing, thus improving the functional properties of both starch and phenolic acids.

Graphical abstract: The interaction between starch and phenolic acids: effects on starch physicochemical properties, digestibility and phenolic acids stability
From the themed collection: Food & Function HOT Articles 2025
Review Article

Harnessing food-derived bioactive peptides for iron chelation: an alternative solution to iron deficiency anemia

The combination of bioactive peptides from various food sources and iron enhances their therapeutic effect on iron deficiency anemia.

Graphical abstract: Harnessing food-derived bioactive peptides for iron chelation: an alternative solution to iron deficiency anemia
From the themed collection: Food & Function HOT Articles 2025
Review Article

Extraction, purification, structural characterization and bioactivity of maize oligosaccharides: a review

Maize (Zea mays L.), as a globally significant food and economic crop, has attracted considerable attention from both the academic and industrial sectors due to its rich nutrient components and wide-ranging application value.

Graphical abstract: Extraction, purification, structural characterization and bioactivity of maize oligosaccharides: a review
From the themed collection: Food & Function HOT Articles 2025
Review Article

Effects of polyphenols on non-alcoholic fatty liver disease: a case study of resveratrol

Plant polyphenols show good potential for preventing chronic metabolic diseases, especially resveratrol, by reducing insulin resistance and fat synthesis linked to non-alcoholic fatty liver disease.

Graphical abstract: Effects of polyphenols on non-alcoholic fatty liver disease: a case study of resveratrol
From the themed collection: Food & Function HOT Articles 2025
Review Article

Dietary and nutritional interventions for human diseases: their modulatory effects on ferroptosis

Interventions targeting ferroptosis are summarized from the perspective of dietary patterns, food and nutrients.

Graphical abstract: Dietary and nutritional interventions for human diseases: their modulatory effects on ferroptosis
From the themed collection: Food & Function HOT Articles 2025
Accepted Manuscript - Paper

Diet, Genetic Factor, and the Risk of Gastroesophageal Reflux Disease, Barrett’s Esophagus and Esophageal Adenocarcinoma

From the themed collection: Food & Function HOT Articles 2025
Accepted Manuscript - Paper

Adherence to the EAT-Lancet reference diet and risk of type 2 diabetes, metabolic dysfunction-associated steatotic liver disease, and their co-occurrence

From the themed collection: Food & Function HOT Articles 2025
Open Access Accepted Manuscript - Paper

Integrating population-based metabolomics with computational microbiome modelling identifies methanol as a urinary biomarker for protective diet-microbiome-host interactions

From the themed collection: Food & Function HOT Articles 2025
Accepted Manuscript - Paper

Dietary hispidulin ameliorated chemically-Induced colitis by inhibiting epithelial cell ferroptosis via the ACAT2-GPX4 axis and remodeling the gut microbiota

From the themed collection: Food & Function HOT Articles 2025
Accepted Manuscript - Paper

Gut microbiota mediated the curvilinear associations between dietary animal protein intake and bone mineral density in Chinese adults

From the themed collection: Food & Function HOT Articles 2025
Paper

Transcriptomic combined physiological analysis illuminated the gastrointestinal stress mechanism of Saccharomyces boulardii

Gastrointestinal stress significantly influences the functionality and survival of food-derived probiotics after ingestion.

Graphical abstract: Transcriptomic combined physiological analysis illuminated the gastrointestinal stress mechanism of Saccharomyces boulardii
From the themed collection: Food & Function HOT Articles 2025
Paper

Non-pungent capsiate enhances longevity and healthspan in Caenorhabditis elegans via transient receptor potential (TRP) channels

Capsiate, a non-pungent capsaicin analog, promotes stress resilience and longevity in C. elegans via TRP channel-dependent activation of DAF-16/FoxO and SKN-1/Nrf2, offering mechanistic insights into its pro-longevity effects.

Graphical abstract: Non-pungent capsiate enhances longevity and healthspan in Caenorhabditis elegans via transient receptor potential (TRP) channels
From the themed collection: Food & Function HOT Articles 2025
Paper

Anti-inflammatory effects of Camellia seed oil on zebrafish and RAW264.7 cells studied using an in vitro bioassay

Camellia seed oil (CSO), extracted from Camellia seeds, contains numerous beneficial bioactive components.

Graphical abstract: Anti-inflammatory effects of Camellia seed oil on zebrafish and RAW264.7 cells studied using an in vitro bioassay
From the themed collection: Food & Function HOT Articles 2025
Open Access Paper

The overlooked impact of background diet and adherence in nutrition trials

Background diet and adherence are key challenges in randomized clinical trials in nutrition. Using data from a sub-cohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), we show how biomarker-based analyses improve outcome estimate.

Graphical abstract: The overlooked impact of background diet and adherence in nutrition trials
From the themed collection: Food & Function HOT Articles 2025
Open Access Paper

Urinary excretion kinetics of (poly)phenolic metabolites derived from the consumption of microwaved Piquillo pepper (Capsicum annuum cv. Piquillo)

(Poly)phenols of Piquillo pepper were extensively metabolized before urinary excretion, showing a strong influence of gut microbiota and a great interindividual variability.

Graphical abstract: Urinary excretion kinetics of (poly)phenolic metabolites derived from the consumption of microwaved Piquillo pepper (Capsicum annuum cv. Piquillo)
From the themed collection: Food & Function HOT Articles 2025
Paper

Vanillin alleviates oxidative stress-mediated neuronal pyroptosis induced in rats by isoproterenol via SIRT1/NOX4/ROS/TXNIP/NLRP3 signaling pathway

Vanillin alleviates neuronal pyroptosis induced in rats by isoproterenol via SIRT/NOX4/ROS/TXNIP/NLRP3 signaling.

Graphical abstract: Vanillin alleviates oxidative stress-mediated neuronal pyroptosis induced in rats by isoproterenol via SIRT1/NOX4/ROS/TXNIP/NLRP3 signaling pathway
From the themed collection: Food & Function HOT Articles 2025
Paper

Collagen peptides promote skin collagen synthesis by modulating the gut microbiota and activating the TGF-β pathway

Hydroxyproline-containing tripeptide-rich collagen peptides (CTP) enhance skin collagen synthesis by modulating the gut microbiota and activating the TGF-β signaling pathway via the gut–immune–skin axis.

Graphical abstract: Collagen peptides promote skin collagen synthesis by modulating the gut microbiota and activating the TGF-β pathway
From the themed collection: Food & Function HOT Articles 2025
Open Access Paper

Milk peptides found in human jejunum induce enteroendocrine hormone secretion and inhibit DPP-IV

The strong effect of protein digestion products on gastrointestinal hormone release is well recognized.

Graphical abstract: Milk peptides found in human jejunum induce enteroendocrine hormone secretion and inhibit DPP-IV
From the themed collection: Food & Function HOT Articles 2025
Paper

Human milk oligosaccharide 2′-fucosyllactose alleviates cognitive impairment via the vagal afferent pathway in Alzheimer's disease mice

2'-FL regulates the composition of gut microbiota and promotes the generation of SCFAs, thereby enhancing VN afferent activity, inhibiting Aβ deposition and neuroinflammatory response, and alleviating spatial and recognition memory impairment in AD.

Graphical abstract: Human milk oligosaccharide 2′-fucosyllactose alleviates cognitive impairment via the vagal afferent pathway in Alzheimer's disease mice
From the themed collection: Food & Function HOT Articles 2025
Paper

The impact of different challenge protocols on immune response in epicutaneously sensitized mice with food allergy

Disrupted skin barrier drives Th2-mediated epicutaneous food allergy, while low-dose oral allergen intake alleviates symptoms by boosting Treg and Th1 responses.

Graphical abstract: The impact of different challenge protocols on immune response in epicutaneously sensitized mice with food allergy
From the themed collection: Food & Function HOT Articles 2025
Paper

Exploring tarhana's prebiotic potential using different flours in an in vitro fermentation model

Tarhana, a traditional fermented food, was studied for its gut health benefits. Variations in flour and fermentation methods shaped microbial diversity and metabolite output, highlighting its prebiotic potential.

Graphical abstract: Exploring tarhana's prebiotic potential using different flours in an in vitro fermentation model
From the themed collection: Food & Function HOT Articles 2025
Paper

Daily consumption of polyphenol-rich grape powder improves muscle strength markers in postmenopausal women

6-wk intake of freeze-dried grape powder improved grip strength and reduced time to complete the gait speed test in postmenopausal women. Irisin level changes positively correlated with grip strength, suggesting a potential mechanistic link.

Graphical abstract: Daily consumption of polyphenol-rich grape powder improves muscle strength markers in postmenopausal women
From the themed collection: Food & Function HOT Articles 2025
Paper

Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis

The activation of microglia is an important cause of central nervous system (CNS) inflammatory cell infiltration and inflammatory demyelination in multiple sclerosis (MS).

Graphical abstract: Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis
From the themed collection: Food & Function HOT Articles 2025
Paper

Bifidobacterium longum BL300 alleviates DSS-induced Colitis by promoting IgA-mediated Gut Microbiota homeostasis

B. longum BL300 can protect against colitis by activating IgA production immune network to reshape gut microbiota, which could further maintain the integrity of the intestinal mechanical barrier and mucus layer.

Graphical abstract: Bifidobacterium longum BL300 alleviates DSS-induced Colitis by promoting IgA-mediated Gut Microbiota homeostasis
From the themed collection: Food & Function HOT Articles 2025
Paper

6-Shogaol inhibits the cell motility of prostate cancer cells by suppressing the PI3K/AKT/mTOR and Ras/Raf/MAPK pathways with comparable effects to paclitaxel treatment

Mechanisms of 6-S for inhibiting the migration and invasion ability in PC-3 and DU145 cells.

Graphical abstract: 6-Shogaol inhibits the cell motility of prostate cancer cells by suppressing the PI3K/AKT/mTOR and Ras/Raf/MAPK pathways with comparable effects to paclitaxel treatment
From the themed collection: Food & Function HOT Articles 2025
Paper

An umbrella review of the association between dietary factors and hepatocellular carcinoma risk

Several meta-analyses have summarized the associations between dietary factors and the risk of hepatocellular carcinoma (HCC).

Graphical abstract: An umbrella review of the association between dietary factors and hepatocellular carcinoma risk
From the themed collection: Food & Function HOT Articles 2025
Paper

Impact of maternal Lactiplantibacillus plantarum S58 supplementation on offspring rat immunity and gut health

Pregnancy and lactation provide several opportunities for maternal dietary interventions to confer health benefits to newborns.

Graphical abstract: Impact of maternal Lactiplantibacillus plantarum S58 supplementation on offspring rat immunity and gut health
From the themed collection: Food & Function HOT Articles 2025
Paper

Crocin extends lifespan by mitigating oxidative stress and regulating lipid metabolism through the DAF-16/FOXO pathway

Crocin extends lifespan, enhances stress resistance, reduces lipid accumulation, and elevates oleic acid levels in the model organism C. elegan through the DAF-16/FOXO pathway.

Graphical abstract: Crocin extends lifespan by mitigating oxidative stress and regulating lipid metabolism through the DAF-16/FOXO pathway
From the themed collection: Food & Function HOT Articles 2025
Paper

Quantity and meal timing of dietary cholesterol intake and cerebrovascular disease mortality

Moderate consumption of dietary cholesterol at dinner rather than breakfast was associated with a lower risk of CBD mortality in a nonlinear manner.

Graphical abstract: Quantity and meal timing of dietary cholesterol intake and cerebrovascular disease mortality
From the themed collection: Food & Function HOT Articles 2025
Paper

Pterostilbene attenuates intestinal barrier damage and secondary liver oxidative stress in a murine model of Clostridium difficile infection by regulating the gut microbiota

Pterostilbene modulated the gut microbiota composition and bile acid profile in CDI mice. This modulation activated intestinal FXR signaling, thereby mitigating colonic inflammation and attenuating liver oxidative stress.

Graphical abstract: Pterostilbene attenuates intestinal barrier damage and secondary liver oxidative stress in a murine model of Clostridium difficile infection by regulating the gut microbiota
From the themed collection: Food & Function HOT Articles 2025
Paper

Synbiotic combination of 2′-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid

The synbiotic combination of 2′-Fucosyllactose and Bifidobacterium animalis subsp. lactis BB-12 supports gut microbiota homeostasis, enhances fecal SCFA levels, and mitigates neurodevelopmental abnormalities in ASD mice.

Graphical abstract: Synbiotic combination of 2′-fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by valproic acid
From the themed collection: Food & Function HOT Articles 2025
Open Access Paper

Application of a dynamic colonic gastrointestinal digestion model to red wines: a study of flavanol metabolism by the gut microbiota and the cardioprotective activity of microbial metabolites

Over the last decade, research has emphasized the role of the microbiome in regulating cardiovascular physiology and disease progression.

Graphical abstract: Application of a dynamic colonic gastrointestinal digestion model to red wines: a study of flavanol metabolism by the gut microbiota and the cardioprotective activity of microbial metabolites
From the themed collection: Food & Function HOT Articles 2025
Paper

Polyphenol oxidase cross-linking enhances whey protein-induced systemic food allergy by regulating miRNA in CD4+ T cells

This study investigates the exacerbating effects of polyphenol oxidase cross-linked whey protein on systemic food allergic reactions.

Graphical abstract: Polyphenol oxidase cross-linking enhances whey protein-induced systemic food allergy by regulating miRNA in CD4+ T cells
From the themed collection: Food & Function HOT Articles 2025
Paper

Lactobacillus rhamnosus LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway

Lactobacillus rhamnosus LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by modulating the gut microbiota and inhibiting the TLR9/NF-κB signaling pathway.

Graphical abstract: Lactobacillus rhamnosus LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway
From the themed collection: Food & Function HOT Articles 2025
Paper

Bifidobacterium bifidum CCFM1359 alleviates intestinal motility disorders through the BDNF-TrkB pathway

Bifidobacterium bifidum CCFM1359 remodels intestinal nerves, dreduces intestinal inflammation through BDNF-TrkB pathway, and improves intestinal microecology to alleviate intestinal motility disorders (created with BioGDP.com).

Graphical abstract: Bifidobacterium bifidum CCFM1359 alleviates intestinal motility disorders through the BDNF-TrkB pathway
From the themed collection: Food & Function HOT Articles 2025
Paper

Preparation, structural characterisation, absorption and calcium transport studies of walnut peptide calcium chelate

Preparation of walnut peptide calcium chelates and their calcium translocation and absorption.

Graphical abstract: Preparation, structural characterisation, absorption and calcium transport studies of walnut peptide calcium chelate
From the themed collection: Food & Function HOT Articles 2025
Paper

The mediating role of C-reactive protein (CRP) in the dietary intake of flavonoids and the risk of albuminuria

Prior experimental investigations have highlighted the beneficial effects of flavonoid consumption on renal function.

Graphical abstract: The mediating role of C-reactive protein (CRP) in the dietary intake of flavonoids and the risk of albuminuria
From the themed collection: Food & Function HOT Articles 2025
41 items

About this collection

This themed collection features articles published in Food & Function marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.

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