A novel protocol for the synthesis of various alkyl and aryl 2-oxetanes leveraging a Giese addition to α-oxy radicals is disclosed, furnishing the desired products in up to 95% yield.
A versatile synthesis of triazole-fused piperazin-2-one and [1,4]diazepin-4-one scaffolds via a cascade azide–alkyne cycloaddition/oxetane ring opening reaction is reported.
Hybrid formulation chemistry was used to internally control the reaction rate differences between radical and cationic photopolymerizations leading to a tailorable array of polymer morphologies and mechanical properties.
Electrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.
Owing to their balanced ring strain and the high regioselectivity of their reactions, oxetanes have emerged as versatile building blocks for heterocycle synthesis.