Strained metal carbene species offer unique reactivity in organic synthesis, which can be leveraged in three key pathways: (1) strain-enabled ring cleavage or expansion, (2) synthesis of small-ring compounds, and (3) strain-enabled cross-metathesis.
Diverse DNA-encoded libraries of complex and novel sp3-rich spirocycles were achieved using a versatile and operationally simple visible light-mediated intermolecular [2 + 2] cycloaddition.
Developments in the synthesis and application of strained spiro heterocycles are discussed, given their potential as non-classical rigid three-dimensional bioisosteres in drug development.
Herein, we report a metal-free catalytic strategy for the efficient synthesis of sulfur-substituted methylenecyclobutanes through the thioaromatization of [1.1.1]propellane. This unprecedented transformation proceeds with excellent atom economy, broad functional group...
We developed a copper-catalyzed stereoselective strategy for the unified synthesis of borylated methylenecyclobutanes. The versatile boromethylene unit greatly expands their structural diversity and potential in future drug discovery.