Developments in the synthesis and application of strained spiro heterocycles are discussed, given their potential as non-classical rigid three-dimensional bioisosteres in drug development.
Diverse DNA-encoded libraries of complex and novel sp3-rich spirocycles were achieved using a versatile and operationally simple visible light-mediated intermolecular [2 + 2] cycloaddition.
A direct and efficient method has been developed for synthesis of isoquinolones from arylamides and internal alkynes using earth abundant Co(III) salt as the catalyst. This approach employs a weakly coordinating primary amide as directing group.
Strained metal carbene species offer unique reactivity in organic synthesis, which can be leveraged in three key pathways: (1) strain-enabled ring cleavage or expansion, (2) synthesis of small-ring compounds, and (3) strain-enabled cross-metathesis.
Metal-free synthesis of sulfur-substituted methylenecyclobutanes via thioarylation of [1.1.1]propellane.