We report herein the construction of 4-quinolones via palladium-catalyzed regioselective β-acyl elimination of 3- hydroxyoxindoles and a subsequent Camps cyclization process.
A two-step, high-yielding transfer hydrogenation/C–H oxidation protocol has been developed for the synthesis of 3-alkyl-3-hydroxyoxindoles and medicinally important 3-cyanomethyl-3-hydroxyoxindole, and formal total synthesis of (±)-alline and (±)-CPC-I.
A diastereoselective aldol-type interception of phenolic oxonium ylides with isatins provides an effective access to 2,2-disubstituted dihydrobenzofuran derivatives in high yields.
A series of enantioenriched spirobenzofuran indolinones were afforded via an asymmetric organocatalytic cascade reaction of 3-hydroxyoxindoles with coumarins. Meanwhile, the stereo-determining step of the reaction was disclosed.
A UV light-driven enantioselective synthesis of 3-hydroxyoxindoles is reported for the first time.