A chemodivergent organolithium-mediated protocol to promote anionic Fries rearrangement (AoF) or kinetic resolution (KR) processes starting from O-aryl carbamates of 2-substituted piperidines is reported.
The synthesis of β-trifluoromethylthiolation enamines and β-trifluoromethylthiolation enamides was realized involving an EDA photochemistry strategy.
From a quinolone library and subsequent medicinal chemistry optimization, we identified the fluoroquinolone 33, which demonstrated anti-ovarian cancer activity through a mechanism involving TRBP and resulting in the modulation of miRNA maturation.
Chiral 3-substituted-4-hydroxypiperidines are highly valuable in pharmaceutical applications due to their diverse and potent biological activities.
Phthalimides are prevalent in pharmaceuticals, and natural products, etc. The synthesis of phthalimides catalyzed by transition metals and under metal-free conditions as well as functionalization of NH-phthalimides are described in this review.