Biocatalytic modification of fluorinated styrene oxide derivatives: improvement of reaction outcome in terms of reaction yield, selectivity and product optical purity by employing reaction engineering approach.
An artificial biocascade platform enables the enantiocomplementary synthesis of chiral 3-hydroxy-γ-butyrolactone from bio-based 1,3-dichloropropanol.
Cyanate-mediated epoxide ring-opening by halohydrin dehalogenases (HHDHs) is a promising method for the synthesis of important optically pure 2-oxazolidinones.
Halogenases and dehalogenases are ubiquitous biocatalysts that mediate halogen incorporation and removal. Synthetic biology is reshaping their catalytic landscapes to unlock new functions and applications.
This highlight presents recent advances in asymmetric synthesis that integrate electrocatalysis with biocatalysis and discusses future development directions in this field.