A series of quinoline derivatives was designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site.
Functionalization of unactivated C(sp3)–H bonds represents one of the interesting transformations in organic synthesis. This review highlights the most recent developments in the cobalt-catalyzed functionalization of unactivated C(sp3)–H bonds.
Considering the therapeutic potential of quinoline moieties, we highlighted here the latest developments in the synthesis of quinoline mimics via C–H bond functionalization strategies.
An intrinsic directing group-assisted site-selective C(sp3)–H alkylation of 8-methylquinolines has been accomplished using readily available aziridines and Pd(II) catalysis.
This review provides an overview of the research advaces in Ni-, Cu-, Fe- and Co-catalyzed directed C(sp3)–H bond functionalization reactions; including design principles, mechanistic discussions, along with potential applications and limitations.