In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
Highly functionalized fluoroalkyl spiropyrazolones are synthesized via an effective [3 + 2] cycloaddition of di/trifluoromethyl hydrazonoyl bromides and alkylidene pyrazolones in good yields.
The intermediary-produced CF2H radical, produced by one-electron oxidation of difluoromethylborates [pinB(Aryl)CF2H][K(18-cr-6)] using photo-redox catalysts, is advantageous for synthesizing the difluoromethylated benzene-fused γ-sultams.
This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
The review summarises various photo- and electrochemical strategies for trifluoromethylation and fluoroalkylation of different C(sp3)–H, C(sp2)–H, and C(sp)–H bonds in several classes of organic molecules.