New quinazolinone nitriles featuring an unusual nitrile group were isolated from the deep-sea-derived Penicillium viridicatum MCCC 3A00265, exhibiting potent activity in reactivating the mutant p53 protein.
We have developed an efficient on-DNA synthesis of viridicatin alkaloid-like conjugates from isatins and DNA-tagged aldehydes.
This review describes natural products that modulate the ubiquitin–proteasome system and their potential for therapeutic agents and the study of life science.
The Ugi multicomponent reaction has acquired a prominent place in modern total synthesis of natural products. Their simplicity and versatility have enabled the development of elegant, efficient, and step-economical sequences toward complex compounds.
The bio-inspired synthesis of alstoscholarinoid B on a gram scale has been accomplished in a nine-step longest linear sequence.