A metal-free and triphosgene-free annulation of diamines with 4-chloro-3-nitrocoumarins enables efficient synthesis of polycyclic benzimidazoheterocycles via extrusion of nitromethane.
This review presents all the recent reports on electro- and photochemical reactions of isatins over the last decade.
A straightforward, moisture insensitive, and regioselective FeIII–CuII/p-TSA–CuI combocatalysed reaction is achieved from isatins and 2-alkynylanilines to diverse 12-benzoyl/benzyl/alkyl indolo[1,2-c]quinazolin-6(5H)-ones with gram-scale scalability and high atom economy.
A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed.
Tryptanthrin with a broad spectrum of biological activities can be not only decorated by various functional groups, but also coordinated by bio-metal ions, generating varied tryptanthrin derivatives as potential anticancer agents with low toxicity.