Dual-nickel/photoredox-catalyzed acylation of spiro-dihydroquinazolinones with carboxylic acids via an aromatization-driven deconstructive strategy

Wen-Chao Gao, Yong Teng, Jie Yang, Wen-Dian Li, Wen-Guang Li, Ke-Xin Huang and Ting Li

Chem. Commun., 2025, 61, 8743
DOI: 10.1039/D5CC01289A

Photocatalytic C–C bond thio(seleno)esterification of 1,2-diketone-derived pro-aromatic intermediates

Amit Pal, Sudip Sarkar, Aaron Shibu, Prakash Maity and Basudev Sahoo

Chem. Commun., 2025, 61, 4714
DOI: 10.1039/D4CC06735E

Organophotoredox-catalyzed deconstructive alkylation/Truce–Smiles rearrangement cascade involving spiro-dihydroquinazolinones and activated alkenes

Mudavath Bhargav Sai Naik, Durga Golagani, Poojasri Dindi and Srirama Murthy Akondi

Chem. Commun., 2025, 61, 11469
DOI: 10.1039/D5CC02774H

Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF3 alkenes

Jin-Hua Zhang, Hong-Jie Miao, Jia-Yi Li, Wenke Li, Pengchen Ma, Xin-Hua Duan and Li-Na Guo

Chem. Commun., 2024, 60, 8095
DOI: 10.1039/D4CC02868F

Modular reductive radical-polar crossover-based acyl migration reactions of N-vinylimides with alkyl, silyl, and acyl radicals

Yutao Jing, Li Zhang, Li Qiu and Yewen Fang

RSC Adv., 2025, 15, 11582
DOI: 10.1039/D5RA01542A

Aerobic alcoholization via aromatization driven C–C bond cleavage of unstrained ketones

Renzhi Liu and Huiying Zeng

Green Chem., 2025, 27, 7329
DOI: 10.1039/D5GC01568E

Photoinduced deacylative epoxidation of ketone derivatives with allylic peroxides

Jiangtao Lin, Mingqian Zhou, Ziyang Li, Jiang Duan, Xiaoyu Liu, Yue Wang and Chao Shu

Chem. Sci., 2026, 17, 10623
DOI: 10.1039/D6SC00898D

Access to quaternary-carbon-containing β-alkyl amides via persulfate-promoted domino alkylation/smiles rearrangement of alkenes

Xiaohu Yang, Xiaoqing Wan, Wen-Chao Yang and Hegui Fang

RSC Adv., 2025, 15, 16183
DOI: 10.1039/D5RA02454D

Synergistic visible-light/Brønsted-acid promoted deconstructive aminoalkylation of spiro dihydroquinazolinones: modular synthesis of α-functionalized unnatural amino acids

Wen-Peng Yang, Hong-Jie Miao, Jia-Yi Li, Xin-Hua Duan and Li-Na Guo

Green Chem., 2025, 27, 14507
DOI: 10.1039/D5GC04059K

Photoinduced three-component alkylpyridination of alkenes via spiro-dihydroquinazolinone fragmentation

Jia-Yi Li, Hong-Jie Miao, Wen-Peng Yang, Xin-Hua Duan and Li-Na Guo

Chem. Commun., 2026, 62, 3564
DOI: 10.1039/D5CC06894K

Molecular Editing of Ketones Derived by Pro-aromatic of Dihydroquinazolinones

Xiaoxiao Yang, Xinyue Ma and Chao Shu

J. Org. Chem., 2025, 90, 12029
DOI: 10.1021/acs.joc.5c01115

Enabling Efficient Synthesis of Dihydrostilbenoid via Palladium-Catalyzed Redox-Neutral Deacylative Arylation

Yafei Wan, Tengfei Kang, Zhehui Xu, Weikang Xiong, Gang Li, Jianyang Dong and Dong Xue

ACS Catal., 2025, 15, 9776
DOI: 10.1021/acscatal.5c02437

Synthesis of Visible-Light-Mediated Cyclopropanes and Cyclic Sultines by Deacylative Radical Addition–Polar Cyclization Cascade from Unstrained Ketones

Hao Wu, Shuguang Chen, Hui Wang and Yongjia Shang

J. Org. Chem., 2025, 90, 17768
DOI: 10.1021/acs.joc.5c02190

Organophotoredox‐Catalyzed Functionalization of Spiro‐Dihydroquinazolinones with Morita–Baylis–Hilman Adducts

Saikat Mondal, Bathula Maheswari, Abuthayir Mohamathu Ghouse and Srirama Murthy Akondi

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70043

Photoredox-Catalyzed Deconstructive Sulfinamidation of Pro-Aromatic Carbocycles: A Sustainable Approach

Wen-Peng Yang, Hong-Fei Liu, Hong-Jie Miao, Yue-Jie Niu, Xin-Hua Duan and Li−Na Guo

J. Org. Chem., 2025, 90, 14195
DOI: 10.1021/acs.joc.5c01834

Hydride Transfer-Enabled Dearomative Spirocyclization of Isoxazoles with O-Alkyl ortho-Oxybenzaldehydes

Lianyi Cao, Shihai Yan, Fangzhi Hu, Fei Wang, Shuai-Shuai Li, Mengzhe Pan, Yingkun Yan and Xiao-Mei Zhang

Org. Lett., 2025, 27, 1835
DOI: 10.1021/acs.orglett.5c00001

Visible-Light-Catalyzed Ring-Opening Alkynylsulfonylation and Vinylsulfonylation of Spiro-Dihydroquinazolinones Enabled by Three-Component Insertion of Sulfur Dioxide

Tao Wang, Li−Na Shi, Ming-Xian Zhang, Shenghu Yan, Yue Zhang, Hang-Dong Zuo and Jia-Yin Wang

J. Org. Chem., 2025, 90, 15765
DOI: 10.1021/acs.joc.5c02033

Photoredox‐Catalyzed Deconstructive Thiolation and Selenylation of Pro‐Aromatic Carbocycles

Wen‐Peng Yang, Jia‐Yi Li, Hong‐Fei Liu, Hong‐Jie Miao, Xin‐Hua Duan and Li‐Na Guo

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202500104

Ketone-Derived Dihydroquinazolinones as Carbamoyl Radical Precursors for Photoredox Amidation of Electron-Deficient Alkenes

Xiu-long Wu, Zhe Jia, Zi-min Hao, Yong-chao Lu, Xiao-ming Zhou, Qian Li, Min Hong and Lei Li

J. Org. Chem., 2026, 91, 6433
DOI: 10.1021/acs.joc.6c00284

Visible‐Light‐Catalyzed Ring‐Opening Halogenation of Spiro‐Dihydroquinazolinones Using Perhalogenated Methanes as Halogen Sources

Yan Hao, Tao Wang, Jin-Yang Zhan, Jun-Ru Li, Shenghu Yan, Meng-Fan Li and Jia-Yin Wang

Eur J Org Chem, 2026, 29
DOI: 10.1002/ejoc.202501240

Photoinduced Multicomponent Sulfonylsulfination of Alkenes via Aromatization-Driven Deconstructive and Radical-Polar Crossover Cyclization Strategies

Wenchao Gao, Yong Teng, Kexin Huang, Wenguang Li, Yongqi Yu, Xu Zhang, Wendian Li and Ting Li

Org. Lett., 2025, 27, 13270
DOI: 10.1021/acs.orglett.5c04276

Visible-Light Induced 1,2-Alkylpyridylation of Alkenes via Deacylation of Unactivated Ketones

Xiaozheng Du, Jingwu Zhang, Tao Sun, Yuan-Yang Guo and Jiaxuan Shen

J. Org. Chem., 2026
DOI: 10.1021/acs.joc.6c00754

A Radical Precursor Based on the Aromatization of p-Quinol Esters Enabled by Pyridine-Boryl Radical

Xiaoli Huang, Ruji Xiong, Cui Yi, Meiqi Bai, Yuhai Tang, Silong Xu and Yang Li

J. Org. Chem., 2025, 90, 3093
DOI: 10.1021/acs.joc.4c02831

Cross-ketone deacylative coupling via oxidative SH2 homolytic substitution

Jian-Xiong Yang, Meng-Yao Zhang, Qi Wen, Jia-Run Wang, Yan Zhang and Heng Jiang

Nat Commun, 2026, 17
DOI: 10.1038/s41467-026-70619-5

Photoinduced Deacylative Phosphorylation of Unstrained Ketones

Long Zhang, Jianing Yu, Xiaoyun Hu, Yuan Chen, Xiying Lai, Linghe Li, Yi Wei and Xiao-Qiang Hu

Org. Lett., 2026, 28, 4549
DOI: 10.1021/acs.orglett.6c00848

Deconstructive Functionalization of Cyclic Ketones via Electrochemical Interrupted Dowd–Beckwith Reaction

Tushar Singha, Jyothirlatha V. N. Kasu and Durga Prasad Hari

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202505155

Deconstructive Functionalization of Cyclic Ketones via Electrochemical Interrupted Dowd–Beckwith Reaction

Tushar Singha, Jyothirlatha V. N. Kasu and Durga Prasad Hari

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505155

Construction of C–S and C–Se Bonds via Photocatalytic Aromatization-Driven Deconstructive Diversification of Spiro-Dihydroquinazolinones Derived from Unstrained Ketones

Tao Wang, Jin-Long Dai, Yi-Feng Jiang, Shenghu Yan and Jia-Yin Wang

J. Org. Chem., 2025, 90, 6776
DOI: 10.1021/acs.joc.5c00499

Transforming an azaarene into the spine of fusedbicyclics via cycloaddition-induced scaffold hopping of 5-Hydroxypyrazoles

You Zhou, Shuang-Gui Lei, Baihetiguli Abudureheman, Li-Sheng Wang, Zhi-Cheng Yu, Jia-Chen Xiang and An-Xin Wu

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-55312-9

1,3-Dimethylimidazolidine-Mediated Acylation of Aryl Halides and Triflates via Photoredox/Nickel Dual Catalysis

Yuan Gao, Zi-Hang Yuan, Liang-Liang Cao, Xin-Hua Duan and Li-Na Guo

Org. Lett., 2026, 28, 535
DOI: 10.1021/acs.orglett.5c05030

Electrochemical Oxidation Ring-Opening of Spiro-Dihydroheteroaromatics with N-(Arylsulfonyl)acrylamides to Form Quinazolinone-Containing Long-Chain Amides

Yuyu Dai, Jiarui Sun, Xiangyu Mou, Yiran Zhao, Xinyu Lu and Xiangsheng Xu

J. Org. Chem., 2026, 91, 6181
DOI: 10.1021/acs.joc.5c02915

Photocatalytic C–C Bond Azidation and Cyanation of Acyclic Ketones via a Pro-aromatic Intermediate

Sandip Bag, Amit Dhibar, Sruthi Moorthy, Akhila Ashokan and Basudev Sahoo

Org. Lett., 2025, 27, 783
DOI: 10.1021/acs.orglett.4c04443

Stereodivergent Deacylative Mizoroki–Heck Reaction of Unstrained Ketones

Kaihang Wei, Yulian Tang, Xiaoping Chen, Beibei Zhan and Xiaheng Zhang

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202518599

Recent Advances in the Radical Reactions of Dihydroquinazolinone Derivatives

Zijie Li, Zheng Hao, Shengyuan Yang, Wenchao Yang and Tao Jin

Chinese Journal of Organic Chemistry, 2025, 45, 3644
DOI: 10.6023/cjoc202501014

Photoinduced Deacylative Radical C−C and C−S Couplings of Unstrained Ketones

Long Zhang, Yuqi Yang, Zhong‐Qiang Zhou, Yi Wei and Xiao‐Qiang Hu

Chin. J. Chem., 2026, 44, 89
DOI: 10.1002/cjoc.70319

Aromatization-Driven C–C Bond Cleavage of Unstrained Ketone Access to Vinyl Sulfones

Hong-Chen Wang, Hong Fu, Peng-Fei Zhao, Yi-Fan Li and Bing Han

Org. Lett., 2025, 27, 14224
DOI: 10.1021/acs.orglett.5c04417

EDOT‐Pyridine Based Dye as Metal‐Free Photoredox Catalyst for Diverse Organic Transformations

Jingjing Ge, Lexuan Kong, Jiaxin Chu, Zhengtao Chen, Yunlai Ren and Wan‐Kai An

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202400817

Deuteration Degree Controllable Synthesis of Aryl Deuteromethyl Ethers Through Dual photoredox and Thiol Catalysis

Junjie Yang, Zhongxian Li, Zhihui Huang and Jun Zhu

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402475

Stereodivergent Deacylative Mizoroki–Heck Reaction of Unstrained Ketones

Kaihang Wei, Yulian Tang, Xiaoping Chen, Beibei Zhan and Xiaheng Zhang

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202518599

Deconstructive Alkynylation of Spiro‐Dihydroquinazolinones via Aromatization‐Driven Ring Opening Under Visible Light Irradiation

Dharavath Ravi, Vadithya Ranga Rao, Vadla Shiva Prasad, Silari MohanaKrishna, Madasu Gangaraju, Chelukalapally Anil Kumar and Praveen Reddy Adiyala

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70428

Synthesis of Polysubstituted Bicyclo[3.1.0]Hexanes via Boronyl Radical Catalyzed [3 + 2] Cycloaddition of Cyclopropanes with Cyclopropenes

Kuan Zhang, Yan Xia, Shanghui Tian, Xin‐Hua Duan, Pengfei Li and Li‐Na Guo

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202401909

Visible Light-Promoted Aromatization-Driven Deconstructive Fluorination of Spiro Carbocycles

Wen-Peng Yang, Hong-Jie Miao, Le Liu, Xin-Hua Duan and Li-Na Guo

Org. Lett., 2024, 26, 7442
DOI: 10.1021/acs.orglett.4c02793

Difluoromethylation of Aryl Halides via Palladium-Catalyzed Redox-Neutral Deacylation

Shihao Li, Mingming Li, Yan Liu, Jingwen Hao, Shaojun Zheng, Zitong Rong, Yi-Si Feng, Nai-Dong Chen and Pan Pan

Org. Lett., 2026, 28, 806
DOI: 10.1021/acs.orglett.5c04966

Photoredox-catalyzed four-atom skeletal editing of 1,3-diketones with alkenes and aldehydes

Wei Wang, Bin Chen, Ting Li, Zhengchu Chen, Lei Yuan, Qiang Fu, Siping Wei, Xiao-Feng Wu and Dong Yi

Chinese Journal of Catalysis, 2026, 82, 212
DOI: 10.1016/S1872-2067(25)64863-7

Benzothiazolines Acting as Carbanion and Radical Transfer Reagents in Carbon–Carbon Bond Construction

Xiaotang Chen and Bao-Chen Qian

Molecules, 2025, 30, 1711
DOI: 10.3390/molecules30081711

Copper‐Catalyzed Aromatization‐Driven Ring‐Opening Amination and Oxygenation of Spiro Dihydroquinazolinones

Wenke Li, Hong‐Jie Miao, Jin‐Hua Zhang, Xin‐Hua Duan and Li‐Na Guo

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402602

Iron‐Catalyzed Decarboxylative and Deconstructive Cross‐Coupling of Acrylic Acids with Ketone‐Derived Dihydroquinazolinones

Xiao‐Yu Lu, Meng‐Xue Su, Hua‐Yi Huang, Yu‐Jun Qian, Hai‐Lun Sun, Xiang Li, Xin‐Ru Hu and Hao‐Yu Dong

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401503

Photoinduced Aromatization-Driven Deconstructive Fluorosulfonylation of Spiro Dihydroquinazolinones

Wen-Peng Yang, Hong-Jie Miao, Gang Wang, Xiaoyu Yang, Xianjun Wang, Le Liu, Xin-Hua Duan and Li-Na Guo

J. Org. Chem., 2024, 89, 18713
DOI: 10.1021/acs.joc.4c02304

Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis

Qi-Chao Shan, Yan Zhao, Yong Wu, Hong-Fei Liu, Xin-Hua Duan and Li-Na Guo

Sci. China Chem., 2024, 67, 3798
DOI: 10.1007/s11426-024-2255-5

Visible Light–Promoted Radical Cascade Bicyclization to Access Partially Saturated Pyrrolo[2,3‐b]Pyridines

Guangpeng Yan, Chengyi Jiang, Shangyu Mao, Ting Zou, Siping Wei, Huirong Xia, Bin Chen, Yao Jian, Dong Yi and Ying Xiong

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202500787

Ketone Skeletal Modification via a Metallaphotoredox-Catalyzed Deacylation and Acylation Strategy

Ke-Han He, Na Jin, Jia-Cai Chen, You-Fen Zheng and Fei Pan

Org. Lett., 2024, 26, 9503
DOI: 10.1021/acs.orglett.4c03456