Dichloromethanol but not difluoromethanol as a viable surrogate of carbon monoxide for prodrug design

Miao Liu, Zhang Li, Ziwei Hu, ZhiCheng Yan, Qingqiang Min, Wei Peng and Xingyue Ji

Chem. Commun., 2023, 59, 5583
DOI: 10.1039/D3CC01486J

Metal-based carbon monoxide releasing molecules with promising cytotoxic properties

Ahmed M. Mansour, Rabaa M. Khaled, Giarita Ferraro, Ola R. Shehab and Antonello Merlino

Dalton Trans., 2024, 53, 9612
DOI: 10.1039/D4DT00087K

Carbon monoxide releasing molecules as antibacterial agents: antibacterial mechanisms, design principles, and controlled methods

Ying Chen, Xin Chen, Yue Bai, Xueyang Zhang, Mingjun Niu, Xuying Liu and Xianghong Wang

J. Mater. Chem. B, 2026, 14, 2058
DOI: 10.1039/D5TB02647D

Unusually air-stable copper(i) complexes showing high selectivity for carbon monoxide

Borna Saeednia, Aria M. Sragow, Yannan Lin, Colton J. Sheehan, Amy S. Metlay, Michael R. Gau, Samantha A. Dye, Sarah P. O'Konski, Thomas E. Mallouk and Ivan J. Dmochowski

Chem. Sci., 2025, 16, 5058
DOI: 10.1039/D5SC00237K

Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation

Upendar Reddy Gandra, Batakrishna Jana, Patrick Hammer, M. Infas H. Mohideen, Ute Neugebauer and Alexander Schiller

Chem. Commun., 2024, 60, 2098
DOI: 10.1039/D4CC00009A

A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

Dongning Liu, Xiaoxiao Yang and Binghe Wang

J. Org. Chem., 2024, 89, 17891
DOI: 10.1021/acs.joc.4c02301

Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology

Nicola Bauer, Zhengnan Yuan, Xiaoxiao Yang and Binghe Wang

Biochemical Pharmacology, 2023, 214, 115642
DOI: 10.1016/j.bcp.2023.115642

Reactive Oxygen Species-Activated Metal-Free Carbon Monoxide Prodrugs for Targeted Cancer Treatment

Zhang Li, Yongming Wang, Miao Liu, Yiyao Pan, Zihui Ni, Qingqiang Min, Binghe Wang, Hengte Ke and Xingyue Ji

J. Med. Chem., 2023, 66, 14583
DOI: 10.1021/acs.jmedchem.3c01056

Inhibitors of NLRP3 Inflammasome Formation: A Cardioprotective Role for the Gasotransmitters Carbon Monoxide, Nitric Oxide, and Hydrogen Sulphide in Acute Myocardial Infarction

Fergus M. Payne, Alisha R. Dabb, Joanne C. Harrison and Ivan A. Sammut

IJMS, 2024, 25, 9247
DOI: 10.3390/ijms25179247

Carbon Monoxide in an Experimental Model of Chronic Pelvic Pain Syndrome: The Effects of CORM-A1 on Pain and Anxiety-Related Behaviors

Nikola Šutulović, Neriman Ezgin, Nela Puškaš, Emilija Đurić, Željko Grubač, Daniel Škrijelj, Milena Vesković, Dušan Mladenović, Isidora Savić, Djuro Macut, Yavuz Dodurga, Aleksandra Rašić-Marković, Olivera Stanojlović and Dragan Hrnčić

Pathophysiology, 2025, 32, 53
DOI: 10.3390/pathophysiology32040053

Obesity and mitochondrial uncoupling – an opportunity for the carbon monoxide-based pharmacology of metabolic diseases

Aleksandra Danielak and Marcin Magierowski

Pharmacological Research, 2025, 215, 107741
DOI: 10.1016/j.phrs.2025.107741

Characterization of the CO release properties of a common CO donor, CORM-401, in the context of its application in studying CO biology

Nicola Bauer, Qiyue Mao, Xiaoxiao Yang and Binghe Wang

Med Chem Res, 2024, 33, 1374
DOI: 10.1007/s00044-024-03221-3

On the Question of CO’s Ability to Induce HO-1 Expression in Cell Culture: A Comparative Study Using Different CO Sources

Xiaoxiao Yang, Qiyue Mao and Binghe Wang

ACS Chem. Biol., 2024, 19, 725
DOI: 10.1021/acschembio.3c00750

Sensing a CO-Releasing Molecule (CORM) Does Not Equate to Sensing CO: The Case of DPHP and CORM-3

Dongning Liu, Xiaoxiao Yang and Binghe Wang

Anal. Chem., 2023, 95, 9083
DOI: 10.1021/acs.analchem.3c01495

Quantifying CO-release from a photo-CORM using 19F NMR: An investigation into light-induced CO delivery

Upendar Reddy Gandra, Jingjing Liu, Jörg Axthelm, Sharmarke Mohamed, Helmar Görls, M. Infas H. Mohideen and Alexander Schiller

Analytica Chimica Acta, 2024, 1312, 342749
DOI: 10.1016/j.aca.2024.342749

CO prodrugs: a new scaffold of adamantane-fused norbornen-7-ones with tunable water solubility

Ce Yang, Xingyue Ji, G. S. Sainaga Jyothi Vaskuri, Xiaoxiao Yang, Wen Lu, Zhengnan Yuan, Dongning Liu, Siming Wang, Chalet Tan and Binghe Wang

Med Chem Res, 2024, 33, 2122
DOI: 10.1007/s00044-024-03312-1

The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament

Fergus M. Payne, Samantha Nie, Gary M. Diffee, Gerard T. Wilkins, David S. Larsen, Joanne C. Harrison, James C. Baldi and Ivan A. Sammut

Physiological Reports, 2024, 12
DOI: 10.14814/phy2.15974

Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide

Nicola Bauer, Qiyue Mao, Aditi Vashistha, Anupamaa Seshadri, Yi‐Chieh Nancy Du, Leo Otterbein, Chalet Tan, Mark P. de Caestecker and Binghe Wang

Medicinal Research Reviews, 2025, 45, 1275
DOI: 10.1002/med.22116

CORM‐A1 delivers carbon monoxide to the kidney and alleviates post‐ischemic renal dysfunction in rat and swine models

Roberta Foresti, Sandra Shurey, Qiyue Mao, Hiroaki Kitagishi, Colin J. Green and Roberto Motterlini

Physiological Reports, 2025, 13
DOI: 10.14814/phy2.70666

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang and Yi‐Chieh Nancy Du

Advanced Science, 2026
DOI: 10.1002/advs.202519898

Synergistic Anti-Ferroptosis with a Minimalistic, Peroxide-Triggered Carbon Monoxide Donor for Parkinson’s Disease

Wenjie Qin, Ruiqi Su, Xiaodie Chen, Zhiyan Liang, Linyan Huang, Xuhong Qian, Youjun Yang, Suhua Qi and Xiao Luo

J. Med. Chem., 2025, 68, 3547
DOI: 10.1021/acs.jmedchem.4c02691

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar and Jingwei Xie

Advanced Science, 2026
DOI: 10.1002/advs.202521942