Lewis acid-catalyzed diastereoselective formal ene reaction of thioindolinones/thiolactams with bicyclobutanes

Avishek Guin, Shiksha Deswal, Mahesh Singh Harariya and Akkattu T. Biju

Chem. Sci., 2024, 15, 12473
DOI: 10.1039/D4SC02194K

Strain-release driven spirocyclization of bicyclo[1.1.0]butanes: access to 6,7-diazaspiro[3.4]octanes

Qin Jiang, Jianyang Dong, Fang Lei, Dejiang Yu, Ting Li, Huaming Sun and Dong Xue

Chem. Sci., 2025, 16, 12189
DOI: 10.1039/D5SC03141A

Recent advances in the synthesis of bicyclo[4.1.1]octanes

Jianyang Dong, Dejiang Yu, Ting Li and Dong Xue

Org. Biomol. Chem., 2025, 23, 5263
DOI: 10.1039/D5OB00533G

Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade

Fangqing Zhang, Chun Xu, Zichun Zhang, Zhuang Yang, Tao Peng, Wen Shao, Xiaoming Feng and Yangbin Liu

Chem. Sci., 2025, 16, 11508
DOI: 10.1039/D5SC01431J

Photochemical α-selective radical ring-opening reactions of 1,3-disubstituted acyl bicyclobutanes with alkyl halides: modular access to functionalized cyclobutenes

Yuanjiu Xiao, Tong-Tong Xu, Jin-Lan Zhou, Feng Wu, Lei Tang, Ruo-Yi Liu, Wen-Biao Wu and Jian-Jun Feng

Chem. Sci., 2023, 14, 13060
DOI: 10.1039/D3SC04457B

Sensing biothiols via thiol-chromene addition triggered fluorophore activation by intramolecular cyclization

Lijia Liu, Xiang Zhang, Minmin Zuo, Haiyang Cui, Xiaoqian Liu, Yajing Wang, Hua-Dong Xu, Zhenjiang Ding and Guodong Hu

Analyst, 2025, 150, 4665
DOI: 10.1039/D5AN00674K

C(sp2)–H cyclobutylation of hydroxyarenes enabled by silver-π-acid catalysis: diastereocontrolled synthesis of 1,3-difunctionalized cyclobutanes

Lei Tang, Qi-Nan Huang, Feng Wu, Yuanjiu Xiao, Jin-Lan Zhou, Tong-Tong Xu, Wen-Biao Wu, Shuanglin Qu and Jian-Jun Feng

Chem. Sci., 2023, 14, 9696
DOI: 10.1039/D3SC03258B

Leveraging chemical synthesis to discover metabolites from the gut microbiome

Allison J. Keys, Nitesh K. Nandwana, Eyas Alnasser and Emily C. Gentry

Ann NY Acad Sci, 2025, 1551, 52
DOI: 10.1111/nyas.70004

Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine

Weifeng Lin, Lars Gerullat, Peder R. Braadland, Anaïs Fournier, Johannes R. Hov and Daniel Globisch

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202318579

Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update

Laura Hillebrand, Xiaojun Julia Liang, Ricardo A. M. Serafim and Matthias Gehringer

J. Med. Chem., 2024, 67, 7668
DOI: 10.1021/acs.jmedchem.3c01825

Synthesis of Cyclobutanes and Cyclobutenes by Strain-Release-Driven Ring-Opening of Bicyclo[1.1.0]butanes

Xuan Zhan, Heng-Xian He, Quanxin Peng and Jian-Jun Feng

Synthesis, 2024, 56, 3829
DOI: 10.1055/a-2402-6920

Advances in chemoselective probes for liquid chromatography-mass spectrometry analysis of small-molecular-weight compounds

Xin-Ze Wu, Hua-Ming Xiao, Na An, Pei-Rong Bai, Yan-Zhen Wang, Azamat Temerdashev, Quan-Fei Zhu and Yu-Qi Feng

Journal of Chromatography Open, 2024, 6, 100154
DOI: 10.1016/j.jcoa.2024.100154

Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine

Weifeng Lin, Lars Gerullat, Peder R. Braadland, Anaïs Fournier, Johannes R. Hov and Daniel Globisch

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202318579

Simple, rapid and enzyme-free assay for potentiometric determination of L-cysteine based on meso-2,3-dimercaptosuccinic acid self-assembled gold electrode

Yuan-Qing Wu, Hong-Shu Xiao, Yu-Yu Peng, Bo-Wen Wu, Bin Li, Yi-Chao Ding, Dan Li, Ling Wu, Donghong Yu and Zhong Cao

Microchemical Journal, 2024, 206, 111548
DOI: 10.1016/j.microc.2024.111548

Advances in dual-function bioprobes for simultaneous detection of transition metal ions (Fe, Cu, Zn) and bioactive species

Jianfei Liu, Xiaokai Wang, Xiaofei Zhu, Yufen Zhao and Yong Ye

Coordination Chemistry Reviews, 2025, 526, 216352
DOI: 10.1016/j.ccr.2024.216352

Insights into the gut-liver axis: mechanisms and emerging therapies in hepatocellular carcinoma

Yongjian Hu, Mingming Gao, Jiajin Chenghuang and Rui Bao

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1595853

Rhodium(III)-Catalyzed Three-Component Diamination of Bicyclo[1.1.0]butanes via Nitrene Transfer

Shunle Hu, Lijuan Jv, Ruijie Mi and Xingwei Li

Org. Lett., 2026, 28, 265
DOI: 10.1021/acs.orglett.5c04645

Engineered Reactive Interfaces Enable Mass Spectrometry Imaging of Multiple Thiols for Decoding PFOS-Induced Redox Dysregulation

Hongmei Xu, Thomas Ka-Yam Lam, Simin Zhang, Lei Guo, Chris Kong Chu Wong, Chuan Dong and Zongwei Cai

Anal. Chem., 2026, 98, 884
DOI: 10.1021/acs.analchem.5c05993

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin and Daniel Globisch

Angewandte Chemie, 2026
DOI: 10.1002/ange.202526122

Shapeshifting Gabriel Amine Synthesis with Iodo-BCPs

Manivel Pitchai, Nanjundaswamy K.C, Sankar Ulaganathan, Mohammad Javeed, Antonio Ramirez, Pavan Srinivas, Sourav Roy, Sarah C. Traeger, James Mignone, Elizabeth A. Jurica, Kumar B. Pabbisetty, Muthalagu Vetrichelvan, Anuradha Gupta, Arvind Mathur and Michael D. Mandler

J. Org. Chem., 2025, 90, 3468
DOI: 10.1021/acs.joc.5c00043

Pattern-based rapid and robust profiling of gut microbiota and its metabolism with a single fluorescent probe

Hongli Tan, Meizi Zeng, Cong Fang, Xiaohua Zhu, Feng Liu, Ying Long, Ruijie Deng, Peng Yin, Meiling Liu, Haitao Li, Youyu Zhang and Shouzhuo Yao

Sci. China Chem., 2025, 68, 781
DOI: 10.1007/s11426-024-2191-y

Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling

Giovanni Andrea Vitale, Shu-Ning Xia, Kai Dührkop, Mohammad Reza Zare Shahneh, Heike Brötz-Oesterhelt, Yvonne Mast, Corinna Brungs, Sebastian Böcker, Robin Schmid, Mingxun Wang, Chambers C. Hughes and Daniel Petras

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-61240-z

One-Step Labeling and Purification: Accelerating FAHFA Detection in Vegetable Oils via Chemoselective Probe-Assisted LC–MS

Xin-Ze Wu, Kai-Wen Tan, Xu Zhang, Jun-Jie Tan, Na An, Fang Cong, Wenbin Wu, Azamat Temerdashev, Quan-Fei Zhu, Hong Wang and Yu-Qi Feng

J. Agric. Food Chem., 2025, 73, 19813
DOI: 10.1021/acs.jafc.5c06401

Smallest Bicycles in Medicinal Chemistry: Where Are We Now?

Vladimir Kubyshkin and Pavel K. Mykhailiuk

Chem. Rev., 2026, 126, 3829
DOI: 10.1021/acs.chemrev.5c00779

Stereoselective Alder-Ene Reactions of Bicyclo[1.1.0]butanes: Facile Synthesis of Cyclopropyl- and Aryl-Substituted Cyclobutenes

Ayan Dasgupta, Subrata Bhattacharjee, Zixuan Tong, Avishek Guin, Ryan E. McNamee, Kirsten E. Christensen, Akkattu T. Biju and Edward A. Anderson

J. Am. Chem. Soc., 2024, 146, 1196
DOI: 10.1021/jacs.3c13080

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin and Daniel Globisch

Angew Chem Int Ed, 2026
DOI: 10.1002/anie.202526122

One‐Pot Construction of NHS‐Activated Magnetic Particles for Chemoselective Capture of Carboxyl Metabolites

Shuai Liu, Meng Yu, Xin‐Yao Luo, Jie Liu and Zhong‐Mei Zou

Advanced Science, 2025, 12
DOI: 10.1002/advs.202413830