Efficient log P determination by automated, spatially encoded 19F NMR spectroscopy

Susanna H. Wood, Fiona Gordon, Robin S. Stein, Mark J. Howard and John A. Parkinson

RSC Med. Chem., 2026, 17, 1550
DOI: 10.1039/D5MD00678C

Recent advances in natural and synthetic phosphonate therapeutics

Jerry Cui and Kou-San Ju

Current Opinion in Microbiology, 2025, 87, 102630
DOI: 10.1016/j.mib.2025.102630

Non‐Hydroxamate Inhibitors of IspC Enzyme in the MEP Pathway: Structural Insights and Drug Development Potential

Yaqing Zhou, Jili Wang, Yong Sun, Yarui Cheng and Wenhai Wu

Chem Biol Drug Des, 2025, 105
DOI: 10.1111/cbdd.70086

DXS, DXR, and HMGR genes play important role in the sesquiterpenoid synthetic pathway in the medicinal herb, Matricaria chamomilla L

Luyao Yu, Ping Yao, Wenjing Cheng, Jin Wang, Siqing Zhu, Honggang Wang, Shuangshuang Li, Feng Shi, Yi Yuan and Yuling Tai

Plant Physiology and Biochemistry, 2025, 229, 110692
DOI: 10.1016/j.plaphy.2025.110692

Expanding the Chemical Space of Reverse Fosmidomycin Analogs

Talea Knak, Sana Takada, Boris Illarionov, Violetta Krisilia, Lais Pessanha de Carvalho, Beate Lungerich, Yasumitsu Sakamoto, Stefan Höfmann, Adelbert Bacher, Rainer Kalscheuer, Jana Held, Markus Fischer, Nobutada Tanaka and Thomas Kurz

ACS Med. Chem. Lett., 2025, 16, 136
DOI: 10.1021/acsmedchemlett.4c00501

Structure−Activity Relationships among Inhibitors of Acinetobacter baumannii and Klebsiella pneumoniae 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR/IspC) − A Promising Target for Antibiotic Development

Misgina Girma, Meagan Belcher Dufrisne, Archi Sehgal, Allyson Dailey, Kenneth Heidel, Darean Bague, Xu Wang, Logan Bartholomew, Richard Beck, Samuel Kirby, Haley Ball, Mosufa Zainab, Soo Hyeon Lee, Iswarduth Soojhawon, Schroeder M. Noble, Cynthia S. Dowd and Robin D. Couch

ACS Infect. Dis., 2026
DOI: 10.1021/acsinfecdis.5c00875

Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use

Pichet Ruenchit

Current Research in Parasitology & Vector-Borne Diseases, 2025, 7, 100256
DOI: 10.1016/j.crpvbd.2025.100256

Fast-Acting Chalcogen-Phosphoranes Inhibit Sensitive and Resistant Plasmodium falciparum Strains

Igor M. R. Moura, Camila S. Barbosa, Giovana Rossi Mendes, Anna Caroline Campos Aguiar, Fabio C. Cruz, Paulo Henrique Menezes and Rafael Victorio Carvalho Guido

ACS Omega, 2026, 11, 2842
DOI: 10.1021/acsomega.5c08794

Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights

Stefan Höfmann, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Shin-ichiro Ozawa, Tanja Gangnus, Talea Knak, Mona A. Abdullaziz, Noemi Wladarz, Adelbert Bacher, Yasumitsu Sakamoto, Bjoern B. Burckhardt, Jana Held, Markus Fischer, Nobutada Tanaka and Thomas Kurz

J. Med. Chem., 2026, 69, 11844
DOI: 10.1021/acs.jmedchem.5c03192