Chemistry of organometallic nucleic acid components: personal perspectives and prospects for the future

Mateusz Klarek and Konrad Kowalski

Dalton Trans., 2024, 53, 18420
DOI: 10.1039/D4DT02634A

Progress and application of cell membrane engineering in living cell therapy

Xiao-Yu Qiu, Yuan-Kai Sun, Jian-Qing Gao and Xin-Chi Jiang

Biomater. Sci., 2025, 13, 3733
DOI: 10.1039/D5BM00120J

Protease-Responsive Bitext Editing Biopolymer for Breast Cancer Imaging In Vivo

Yixi Dong, Gang Wang, Noshin Afshan, Tao Cheng, Bin Ning, Jianwei Jiao and Jin Jiao

ACS Materials Lett., 2024, 6, 3815
DOI: 10.1021/acsmaterialslett.4c00229

PAIT effect: Padlock activator inhibits the trans-cleavage activity of CRISPR/Cas12a

Xueying Lei, Lihua Ding, Xiaonan Yang, Feng Xu, Yongjun Wu and Songcheng Yu

Biosensors and Bioelectronics, 2024, 263, 116607
DOI: 10.1016/j.bios.2024.116607

Controllable Assembly of a DNAzyme Feedback Nanowire for Single-Molecule Detection of Fat Mass and Obesity-Associated Protein in Clinical Breast Cancer Samples

Qian Zhang, Jiawen Liu, Yanbo Wang and Chun-yang Zhang

Anal. Chem., 2025, 97, 21721
DOI: 10.1021/acs.analchem.5c04895

Patterning technologies in bioanalysis: From sensing surface construction to detection applications

Mingyang Liu, Zhiwei Sun, Ying Zhang, Shenguang Ge, Haina Huang, Lin Han, Xiaoyan Liu, Weijia Zhou and Hong Liu

Materials Science and Engineering: R: Reports, 2026, 168, 101172
DOI: 10.1016/j.mser.2025.101172

Recent Advances in DNA‐Based Nanoprobes for In vivo MiRNA Imaging

Caixia Wang, Xuefang Song, Jieyu Shen, Yuxin Xie, Huangxian Ju and Ying Liu

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402566

Crafting Immune‐Cancer Cell Crosstalk via Modular Multilayer Logic DNA Nanoadaptors

Yihan Wang, Qianying Zhang, Zejing Xing, Yuxin Wang, Yide Huang, Jun‐Jie Zhu and Qianhao Min

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202513673

Restoring Cell–Cell Communication to Elicit Bystander Effect Using a DNA‐Based Nanocomplex for Robust Immunotherapy

Yinuo Shu, Guoshi Xu, Minhao Jiang, Yanjie Zhang, Yinghua Peng, Jiawei Zhu, Weiguang Chen, Fang Pu, Jinsong Ren and Xiaogang Qu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202506079

DNAzyme‐Based Nanostructures for Dynamic Cell Regulation and Sensing

Haoyu Fan, Xichen Du and Ruocan Qian

ChemistryOpen, 2026, 15
DOI: 10.1002/open.202600004

DNA‐Assisted Separation of Nanoparticles

Ying Sun, Yuchuan Liu, Daqian Song and Feng Chen

Small Methods, 2025, 9
DOI: 10.1002/smtd.202401389

DNA‐based Precision Tools to Probe and Program Mechanobiology and Organ Engineering

Nihal Singh, Ayushi Sharma, Anjana Goel, Krishan Kumar, Raghu Solanki and Dhiraj Bhatia

Small, 2025, 21
DOI: 10.1002/smll.202410440

Dual Gatekeepers-Driven Signal Amplification Strategy for Precise Detection and Modulation of Ovarian Cancer Exosome Subtypes

Ying Chen, Liang Shen, Yuan Wei, Rui Guo, Jianwei Jiao, Lulu Xu and Yuna Guo

ACS Sens., 2025, 10, 7427
DOI: 10.1021/acssensors.5c01282

Engineering of DNA nanostructure-based artificial cells for biosensing applications

Yuping Cheng, Zhaoxin Li, Chunjuan Zhang, Xinyan He, Jing Zheng and Jianbo Liu

TrAC Trends in Analytical Chemistry, 2025, 192, 118419
DOI: 10.1016/j.trac.2025.118419

Assembly of DNA Networks on the Cell Membrane Enables Confined Detection of MMP-9 Secretion and Evaluation of Drug Efficacy

Qi Hu, Peishan Li, Wenkai Cao, Jiaqi Li, Zhaojia Wang, Tianze Wang and Xiaoyu Xie

Anal. Chem., 2025, 97, 11745
DOI: 10.1021/acs.analchem.5c01169

Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly

Lingzhi Cao, Xinjian Yang, Yimei Li, Yang Yang, Qiulin Liu, Massimo Bottini, Yi Jin, Bei Wang, Jinchao Zhang and Xing-jie Liang

ACS Nano, 2024, 18, 18046
DOI: 10.1021/acsnano.4c05216

DNA Logic-Gated CRISPR/Cas13a and PNTs-Hemin Biomimetic Nanozyme for Ratiometric Detection of BRCA1 and circROBO1

Xiaoxing Xu, Rongqi Zhang, Guifang Hai, Yani Wang, Haobo Zheng, Peng Cui, Beibei Kou, Xiaoyong Jin and Juan Peng

Anal. Chem., 2026, 98, 7580
DOI: 10.1021/acs.analchem.5c07475

Crafting Immune‐Cancer Cell Crosstalk via Modular Multilayer Logic DNA Nanoadaptors

Yihan Wang, Qianying Zhang, Zejing Xing, Yuxin Wang, Yide Huang, Jun‐Jie Zhu and Qianhao Min

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202513673

Innovative MRSA-infected wound repair strategy: NIR-triggered controllable NO releasing from plant extracts quercetin composite chitosan/hyaluronic acid hydrogel

Yifu Wang, Jinjin Li, Linlin Ding, Xiaolan Gao, Zhilan Chi, Shanshan Ma, Leiliang He and Yamin Xiong

International Journal of Biological Macromolecules, 2025, 319, 145326
DOI: 10.1016/j.ijbiomac.2025.145326

Bioorthogonal chemistry-triggered engineering on cell membrane for precise bioimaging in living organisms

Yu Ma, Guowei Liang, Jue Wang, Xianbao Sun, Wenjun Zhan and Gaolin Liang

TrAC Trends in Analytical Chemistry, 2026, 195, 118557
DOI: 10.1016/j.trac.2025.118557

Dynamic DNA Circuits for Biomedical Applications

Xinghua Chen, Zhixin Zhou, Eli Pikarsky and Itamar Willner

ACS Nano Med., 2026, 1, 1073
DOI: 10.1021/acsnanomed.5c00176

Biophysical-to-DNA Catalytic Cumulative Birecorder for Measuring Continuous Membrane Fluidity

Mengying Ye, Xinyin Li, Lu Huang, Xinru Mei, Huahang Yu, Ke Cao, Feng Chen and Yongxi Zhao

J. Am. Chem. Soc., 2025, 147, 47523
DOI: 10.1021/jacs.5c16545

Functional Nucleic Acids for Cell–Cell Interactions

Zhirou Zhang, Yanfei Liu, Qiwen Chen, Yongbo Liu, Yifu Tan, Yunqi Man, Zhongyu Cheng, Kan Shao, Qian Wang, Shuqing Du, Zexiang Lv and Zhenbao Liu

Small, 2026, 22
DOI: 10.1002/smll.202512348

DNA Tetrahedral Sensors for Visualizing miR-21-Mediated Angiogenesis

Shuhang Yin, Binbin Li, Boru Peng, Yongyan Shi, Feng Chen, Qiujun Lu, Xiaohua Zhu, Meiling Liu, Haitao Li and Youyu Zhang

Anal. Chem., 2025, 97, 19249
DOI: 10.1021/acs.analchem.5c03072

Self assembling fluorescent biosensing system based on rolling circle amplification combined with DNA templated quantum dots for detecting microbial DNA

Xin Wang, Yan Zeng, Peng Qi, Peng Wang, Wei Wang and Di Wang

Sensors and Actuators B: Chemical, 2026, 450, 139286
DOI: 10.1016/j.snb.2025.139286

Regulation of Tumor-Immune Cell Communications via Enantioselectively Targeting SLC G-Quadruplexes

Yue Sun, Heying Yuan, Hualong Song, Chuanqi Zhao, Miles Postings, Peter Scott, Wenxuan Hu, Na Zhang, Jinsong Ren and Xiaogang Qu

J. Am. Chem. Soc., 2026
DOI: 10.1021/jacs.6c07127

Proximity Effect-Mediated DNA Self-Assembly for the Highly Specific Detection of Glioma-Derived Exosomes by Combining Multiple Exosomal Surface Markers

Xueying Zhao, JinJin Li, Yi Hao, Xiaolan Gao, Yifu Wang, Leiliang He and Yamin Xiong

ACS Sens., 2025, 10, 9264
DOI: 10.1021/acssensors.5c00951

Cholesterol modulation in drug delivery systems and tumor therapy: Strategies and perspectives

Shuzhen Kang, Yang Li, Yuan Gao, Li Kong and Zhiping Zhang

Journal of Controlled Release, 2025, 388, 114317
DOI: 10.1016/j.jconrel.2025.114317

Cell‐Targeting Bio‐Catalytic Killer Protocell for High‐Order Assembly Guided Cancer Cell Inhibition

Shuhan Xiong, Zeqi Huang, Vincent Mukwaya, Weili Zhao, Li Wang and Hongjing Dou

Small, 2025, 21
DOI: 10.1002/smll.202500047

Harnessing Nanomaterials for Enhanced DNA‐Based Biosensing and Therapeutic Performance

Xumin Pan, Xiaoman Zhao, Yanhong Lu, Ping Xie, Lan Liu and Xia Chu

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400936

Cell surface engineering via self-assembly DNA networks for cell behavior control

Tianshu Chen, Xuexue Liu, Xiaochen Tang, Ji Ma, Siwei Mao, Miao Ding, Ni Zhen, Qizhi Diao and Qiuhui Pan

Front. Bioeng. Biotechnol., 2026, 14
DOI: 10.3389/fbioe.2026.1834218

Restoring Cell–Cell Communication to Elicit Bystander Effect Using a DNA‐Based Nanocomplex for Robust Immunotherapy

Yinuo Shu, Guoshi Xu, Minhao Jiang, Yanjie Zhang, Yinghua Peng, Jiawei Zhu, Weiguang Chen, Fang Pu, Jinsong Ren and Xiaogang Qu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202506079

Multi-DNAzymes cascade reaction mediated aptasensors for OTA detection based on the integration of autocatalytic Mg2+-dependent DNAzyme cleavage and entropy-driven circuit

Wenshan Li, Qingqing Li, Huaiyue Xia, Wenjie Liu, Guoxing Jing, Jianna Yu, Wen Liu, Mengtong Lin and Yujuan Huang

International Journal of Biological Macromolecules, 2025, 289, 138896
DOI: 10.1016/j.ijbiomac.2024.138896

Identification of a myosin 1B-binding aptamer for fluorescence imaging and targeted therapy of esophageal squamous cell carcinoma

Zhaoting Wang, Xiaoxiong Xiao, Tianlu Zhang, Xiao Li, Mengmeng Ji, Yongqi Qian, Xue Bai, Xin Li, Jing Lu, Jinlu Tang, Kangdong Liu, Zhaohui Li and Baoyin Yuan

Materials Today Bio, 2026, 37, 102867
DOI: 10.1016/j.mtbio.2026.102867