Recent developments in the enzymatic modifications of steroid scaffolds

Huibin Wang and Ikuro Abe

Org. Biomol. Chem., 2024, 22, 3559
DOI: 10.1039/D4OB00327F

Steroidal alkaloid with unprecedented triheterocyclic architecture

Zhong-Shun Zhou, Yun-Li Zhao, Bin-Yuan Hu, Bei Wang, Ya-Ping Liu, Yan-Yan Zhu, Ying-Jie He, Zhao-Jie Wang, Zhi Dai, Li-Xing Zhao and Xiao-Dong Luo

Chem. Commun., 2023, 59, 326
DOI: 10.1039/D2CC06073F

Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum

Jongbu Lim, Keunhwa Kim, Jung Heo, Seung Mo Seo, Sungjun Choung, Hyeonjin Kim, Yuri Choi, Kyungsun Park, Hyejung Yun, Dongha Kim, Eun Song Lee, Junwoo Lee, Smita Mirsyad Warsadiharja, Saet Buyl Lee, Sunkyu Han, Soon Ju Park and Sang‐Gyu Kim

Plant Biotechnology Journal, 2026
DOI: 10.1111/pbi.70551

GAME15: a pivotal nexus unlocking solanum alkaloid metabolism and biosynthesis underpinning the chemical defense and pharmacological potential in Solanum species

Xiaoxu Li, Ye Feng, Wencan He, Suxing Tuo, Guoxin Chen, Jinhao Sun, Zhiyuan Li, Kejun Zhong, Wei Luo and Bo Kong

Front. Plant Sci., 2025, 16
DOI: 10.3389/fpls.2025.1730777

Biotechnological detoxification: an unchanging source–sink balance strategy for crop improvement

Yongming Liu, Hussam Hassan Nour-Eldin, Ling Zhang, Zhanshuai Li, Alisdair R. Fernie and Maozhi Ren

Trends in Plant Science, 2023, 28, 135
DOI: 10.1016/j.tplants.2022.11.002

Role of Gut Bacteria in Tomato Leaf Miner Tuta absoluta Gaining Resistance to α-Tomatine by Converting It to Cholesterol

Yaping Chen, Yao Chen, Ewei Du, Xiaofeng Chen, Wanxue Liu, Yahong Li, Na Zeng, Xiaoyan Zi, Qing He, Zhuorong Li, Runzheng Su and Furong Gui

J. Agric. Food Chem., 2026, 74, 9168
DOI: 10.1021/acs.jafc.5c16815

Genomics of sterols biosynthesis in plants: Current status and future prospects

Harshad A. Shirke, Ashwini M. Darshetkar, Vikas B. Naikawadi, P.B. Kavi Kishor, Tukaram D. Nikam and Vitthal T. Barvkar

Plant Science, 2025, 353, 112426
DOI: 10.1016/j.plantsci.2025.112426

Application of TLC and UHPLC–QTOF–MS for the identification of aqueous two-phase extracted UV–fluorescent metabolites from Solanum retroflexum

Tebogo Mphatlalala Mokgehle, Ntakadzeni Madala, Wilson Mugera Gitari and Nikita Tawanda Tavengwa

JPC-J Planar Chromat, 2021, 34, 353
DOI: 10.1007/s00764-021-00123-7

Genome-wide identification and expression analysis of watermelon (Citrullus lanatus) SSR2 gene during fruit development

Jing Zhang, Yan-Ge Li, Hao-Ting Sun, Ding-Ding Zuo, Yang Qiao, Rui Sun, Jia-Lin Xing, Zhong-Hou Zhu, Xue-Jie Zhu and Da-Long Guo

Chem. Biol. Technol. Agric., 2024, 11
DOI: 10.1186/s40538-024-00624-7

A Jasmonate-Responsive ERF Transcription Factor Regulates Steroidal Glycoalkaloid Biosynthesis Genes in Eggplant

Tsubasa Shoji and Kazuki Saito

Plants, 2022, 11, 3336
DOI: 10.3390/plants11233336

Alkaloid evolution in the Solanaceae

Pablo A. Pérez-Mesa and Federico Roda

Current Opinion in Plant Biology, 2025, 85, 102727
DOI: 10.1016/j.pbi.2025.102727

Alpha-tomatine and the two sides of the same coin: An anti-nutritional glycoalkaloid with potential in human health

Catarina Faria-Silva, Miriam de Sousa, Manuela Colla Carvalheiro, Pedro Simões and Sandra Simões

Food Chemistry, 2022, 391, 133261
DOI: 10.1016/j.foodchem.2022.133261

Multispectroscopic and molecular modeling strategy to explore the interaction of cholest-5-en-7-one with human serum albumin: DFT and Hirshfeld surface analysis

Mahboob Alam

Journal of King Saud University - Science, 2021, 33, 101661
DOI: 10.1016/j.jksus.2021.101661

Anticholesterol activity of ethanol extract of Ranti Hitam (Solanum blumei Nees ex Blume) Leaves: In vivo and In silico study

Murniaty Simorangkir, Saronom Silaban and Destria Roza

PHAR, 2022, 69, 485
DOI: 10.3897/pharmacia.69.e84913

Multiomic Analysis Reveals Core Regulatory Mechanisms underlying Steroidal Glycoalkaloid Metabolism in Potato Tubers

Dan-dan Shen, Ying-peng Hua, Jin-yong Huang, Shu-ting Yu, Tai-bo Wu, Yannning Zhang, Huan-li Chen and Cai-peng Yue

J. Agric. Food Chem., 2022, 70, 415
DOI: 10.1021/acs.jafc.1c06867

Phytochemical analysis and allelopathic effects of aqueous extracts of Solanum americanum Mill. and Solanum stramoniifolium Jacq. on Lactuca sativa L.

José Jailson Lima Bezerra, Ana Beatriz Felix Leonardo, Ingrid Coriolano Barbosa and Antonio Fernando Morais de Oliveira

Ecological Frontiers, 2025, 45, 829
DOI: 10.1016/j.ecofro.2025.02.006

Chemistry and bioactivities of natural steroidal alkaloids

Mei-Ling Xiang, Bin-Yuan Hu, Zi-Heng Qi, Xiao-Na Wang, Tian-Zhen Xie, Zhao-Jie Wang, Dan-Yu Ma, Qi Zeng and Xiao-Dong Luo

Nat. Prod. Bioprospect., 2022, 12
DOI: 10.1007/s13659-022-00345-0

Isolation and Characterisation of Bioactive Steroidal Compounds From the Leaf Extract of Sarcochlamys pulcherrima

Manab Jyoti Goswami, Rajesh Chakrabarty, Babulal Das and Dwipen Kakati

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202500100

A time-resolved metabolomics study of potato cultivar responses to Pseudomonas syringae

Lindiwe Mahlangu, Khayalethu Ntushelo, Ntakadzeni Edwin Madala and Phumzile Sibisi

Front. Plant Sci., 2026, 17
DOI: 10.3389/fpls.2026.1760708

Metabolite profiling and transcriptomic analyses demonstrate the effects of biocontrol agents on alkaloid accumulation in Fritillaria thunbergii

Xuemei Cheng, Dishuai Li, Zheng Jiang, Cheng Qu, Hui Yan and Qinan Wu

BMC Plant Biol, 2023, 23
DOI: 10.1186/s12870-023-04459-6

UHPLC-MS/MS Analysis of the Accumulation and Excretion of Steroidal Glycoalkaloids Consumed by Potato Tuber Moth (Phthorimaea operculella) Larvae under Different Feeding Treatments

Yajin Li, Qiong Wang, Xiaoyu Xu and Huachun Guo

Insects, 2022, 14, 26
DOI: 10.3390/insects14010026

Steroidal glycoside profile differences among primary roots system and adventitious roots in Solanum dulcamara

Ilaria Chiocchio, Nerea Pérez Andrés, Redouan Adam Anaia, Nicole M. van Dam and Fredd Vergara

Planta, 2023, 257
DOI: 10.1007/s00425-023-04072-9

Enzymatic twists evolved stereo-divergent alkaloids in the Solanaceae family

Adam Jozwiak, Michaela Almaria, Jianghua Cai, Sayantan Panda, Hadas Price, Ron Vunsh, Margarita Pliner, Sagit Meir, Ilana Rogachev and Asaph Aharoni

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-59290-4

Comparative transcriptome analysis of different tissues of Solanum khasianum reveals candidate genes involved in steroidal glycoalkaloid biosynthesis

Shuaishuai Zhang, Tingyu Shan, Jingyao Xu, Liqiang Zhao and Jiawen Wu

Physiologia Plantarum, 2023, 175
DOI: 10.1111/ppl.14010

Alternaria diseases on potato and tomato

Tamara Schmey, Christopher S. Tominello‐Ramirez, Carolin Brune and Remco Stam

Molecular Plant Pathology, 2024, 25
DOI: 10.1111/mpp.13435

Dissecting the biosynthesis, regulation, and metabolic engineering of steroidal glycoalkaloids in tomato

Jiayi Chen, Mingchun Liu, Yang Zhang and Feng Bai

JIPB, 2026, 68, 861
DOI: 10.1111/jipb.70077

A metabolon at the heart of steroidal biosynthesis

Tsubasa Shoji and Satoru Sawai

Trends in Plant Science, 2025, 30, 812
DOI: 10.1016/j.tplants.2025.03.015

Phytochemical and pharmacological studies on Solanum lyratum: a review

Yue Zhao, Wen-Ke Gao, Xiang-Dong Wang, Li-Hua Zhang, Hai-Yang Yu and Hong-Hua Wu

Nat. Prod. Bioprospect., 2022, 12
DOI: 10.1007/s13659-022-00361-0

Endophytic Beauveria bassiana of Tomato Resisted the Damage from Whitefly Bemisia tabaci by Mediating the Accumulation of Plant-Specialized Metabolites

Xian Wang, Ganwei Yan, Wenjie Liu, Haolin Chen, Qian Yuan, Ziying Wang and Huai Liu

J. Agric. Food Chem., 2023, 71, 13244
DOI: 10.1021/acs.jafc.3c03679

Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines

Allegra Peletta, Aurélie Marmy, Samo Guzelj, Alcidia Ramos Barros, Žiga Jakopin and Gerrit Borchard

Front. Drug Deliv., 2024, 4
DOI: 10.3389/fddev.2024.1382266

Antioxidant activity, cytotoxicity and antibacterial activity of Solanum mauritianum Scop. (Solanaceae) extracts

Myuri Parusnath, Yougasphree Naidoo and Moganavelli Singh

South African Journal of Botany, 2026, 193, 145
DOI: 10.1016/j.sajb.2026.04.024

Glycoalkaloids in potatoes: exploring health effects, analytical techniques, occurrence, mitigation measures

João Gonçalves Figueira, Sílvia Cruz Barros, Estefania Valero-Cases and Ana Sanches Silva

Food and Chemical Toxicology, 2026, 207, 115807
DOI: 10.1016/j.fct.2025.115807

Determination of Bioactive Compounds, Antioxidant Capacities and Safety of the Somatic Hybrid Potatoes

Mariem Kammoun, Khaoula Ben Jeddou, Veli-Matti Rokka, Juha-Matti Pihlava, Jarkko Hellström, Liz Gutiérrez-Quequezana, Mohamed Farouk Essid, Radhia Gargouri-Bouzid and Oumèma Nouri-Ellouz

Potato Res., 2022, 65, 881
DOI: 10.1007/s11540-022-09559-8

Identification of superior thermotolerant tomato hybrids through a multi-selection phenotypic and genotypic approach

Salvatore Graci, Silvana Francesca, Matteo Addonizio, Maria Manuela Rigano and Amalia Barone

Scientia Horticulturae, 2025, 350, 114358
DOI: 10.1016/j.scienta.2025.114358

Reaction Rate and Stereoselectivity Enhancement in Glycosidations with O-Glycosyl Trihaloacetimidate Donors due to Catalysis by a Lewis Acid–Nitrile Cooperative Effect

Tianlu Li, Tong Li, Yue Yang, Yongshun Qiu, Yingguo Liu, Miaomiao Zhang, Haoru Zhuang, Richard R. Schmidt and Peng Peng

J. Org. Chem., 2024, 89, 7865
DOI: 10.1021/acs.joc.4c00554

Untargeted metabolomics reveals key steroidal glycoalkaloids and associated metabolites in crude and C18-purified extracts of potato leaves

Yuru Lv, Yue Chang, Yongyu Fang, Yating Hao, Ruigang Wang, Zhicheng Zhang, Xianmei Xi, Rui Xie, Jie Feng and Lizhen Nie

BMC Plant Biol, 2026
DOI: 10.1186/s12870-026-08606-7

Revisiting steroidal glycoalkaloids as hatching stimulants for Globodera rostochiensis and Globodera pallida

Andrea Caroline Ruthes, Evelin Tiralongo and Paul Dahlin

Pest Management Science, 2025, 81, 4848
DOI: 10.1002/ps.8850

ELONGATED HYPOCOTYL 5 regulates steroidal glycoalkaloids biosynthesis and bitterness removal in tomato fruit

Lan‐Ting Xiang, Xuan‐Xi Tao, Zhou‐Ning Jiang and Da‐Qi Fu

The Plant Journal, 2026, 125
DOI: 10.1111/tpj.70827

Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells

Lucas Keuter, Alessa Wolbeck, Matthias Kasimir, Lina Schürmann, Matthias Behrens and Hans‐Ulrich Humpf

Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202300639

Health Benefits of the Alkaloids from Lobeira (Solanum lycocarpum St. Hill): A Comprehensive Review

Felipe Tecchio Borsoi, Glaucia Maria Pastore and Henrique Silvano Arruda

Plants, 2024, 13, 1396
DOI: 10.3390/plants13101396

The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties

Christian Bailly

Steroids, 2021, 176, 108933
DOI: 10.1016/j.steroids.2021.108933

A multi-omics approach unveils the regulatory network of alkaloid biosynthesis in potato tubers and identifies StHSF1 as an important activator

Xiaoqiang Qiu, Zhen Liu, Jinyong Zhu, Zhitao Li, Minmin Bao, Ziyi Xiao, Panfeng Yao, Zhenzhen Bi, Yuhui Liu and Yuanming Li

Food Bioscience, 2026, 79, 108792
DOI: 10.1016/j.fbio.2026.108792

Deterministic and probabilistic health risk assessment of α‐chaconine and α‐solanine in potato products consumed in Korea

Songyi Han, Sujin Oh, Sukyeong Jang, Jian Lee and Byung Hee Kim

Journal of Food Science, 2025, 90
DOI: 10.1111/1750-3841.70117

Steroidal glycoalkaloids contribute to anthracnose resistance in Solanum lycopersicum

Matthew L Fabian, Chong Zhang, Jianghao Sun, Neil P Price, Pei Chen, Christopher R Clarke, Richard W Jones, John R Stommel and Fabrizio Costa

Journal of Experimental Botany, 2023, 74, 3700
DOI: 10.1093/jxb/erad108

Antimicrobial Activities of Solanum aculeastrum Fruit Extract against Escherichia coli, Staphylococcus aureus and Candida albicans: Significance of African Traditional Medicine in Combating Infections and Attaining Universal Health Coverage

Christabel Nang’andu Hikaambo, Phanuel Chilala, Ferdinand Ndubi, Godfrey Mayoka, Martin Kampamba, Reagan Kabuka, Billy Chabalenge and Steward Mudenda

PP, 2023, 14, 176
DOI: 10.4236/pp.2023.145013

GWAS in tetraploid potato: identification and validation of SNP markers associated with glycoalkaloid content

Peter G. Vos, M. João Paulo, Peter M. Bourke, Chris A. Maliepaard, Fred A. van Eeuwijk, Richard G. F. Visser and Herman J. van Eck

Mol Breeding, 2022, 42
DOI: 10.1007/s11032-022-01344-2

Biorefinery perspective for industrial potato peel management: technology readiness level and economic assessment

P.V. Almeida, L.M. Gando-Ferreira and M.J. Quina

Journal of Environmental Chemical Engineering, 2023, 11, 110049
DOI: 10.1016/j.jece.2023.110049

Recent developments and emerging trends in dietary vitamin D sources and biological conversion

Xujin Wei, Jessica Pandohee and Baojun Xu

Critical Reviews in Food Science and Nutrition, 2024, 64, 10121
DOI: 10.1080/10408398.2023.2220793

Development of a cascade production system finalized to the extraction of all-tomatine-rich fraction using the tomato cannery waste as feedstock

Parisa Abbasi-Parizad, Rosachiara Antonia Salvino, Alessandro Passera, Alessia Regina Vera Follador, Cesare Cosentino, Costanza Jucker, Sara Savoldelli, Jacopo Bacenetti, Paola Casati and Barbara Scaglia

Journal of Cleaner Production, 2023, 401, 136743
DOI: 10.1016/j.jclepro.2023.136743

Potato steroidal glycoalkaloids: properties, biosynthesis, regulation and genetic manipulation

Yongming Liu, Xiaowei Liu, Yingge Li, Yanfei Pei, Abdul Jaleel and Maozhi Ren

Mol Horticulture, 2024, 4
DOI: 10.1186/s43897-024-00118-y

Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network

Feng Bai, Mengbo Wu, Wei Huang, Weijie Xu, Yikui Wang, Yang Zhang, Zhenhui Zhong, Yiguo Hong, Julien Pirrello, Mondher Bouzayen and Mingchun Liu

Sci. Adv., 2025, 11
DOI: 10.1126/sciadv.ads9601

Tomatoes supply the ‘sunshine vitamin’

Dominique Van Der Straeten and Simon Strobbe

Nat. Plants, 2022, 8, 604
DOI: 10.1038/s41477-022-01158-2

Constitutive Level of Specialized Secondary Metabolites Affects Plant Phytohormone Response to Above- and Belowground Herbivores

Kayleigh C. Hauri, Anthony L. Schilmiller, Elisabeth Darling, Amanda D. Howland, David S. Douches and Zsofia Szendrei

J Chem Ecol, 2024, 50, 549
DOI: 10.1007/s10886-024-01538-2

The Activity of Solanum tuberosum Leaf Extract and Chaconine in the Gut of Tenebrio molitor Larvae

Malgorzata Slocinska, Justyna Mirek, Zbigniew Adamski and Jan Lubawy

Toxins, 2026, 18, 157
DOI: 10.3390/toxins18040157

Steroidal scaffold decorations in Solanum alkaloid biosynthesis

Rosalind Lucier, Mohamed O. Kamileen, Yoko Nakamura, Sofiia Serediuk, Ranjit Barbole, Jens Wurlitzer, Maritta Kunert, Sarah Heinicke, Sarah E. O’Connor and Prashant D. Sonawane

Molecular Plant, 2024, 17, 1236
DOI: 10.1016/j.molp.2024.06.013

Unusual ring B-seco isosteroidal alkaloid, yibeiglycoalkaloids A−E from Fritillaria pallidiflora schrenk

Qiang Dong, Jun Li, Liu Liu, Haji Akber Aisa and Abulimiti Yili

Phytochemistry, 2022, 203, 113351
DOI: 10.1016/j.phytochem.2022.113351

Gene expression and phytohormone levels in the asymptomatic and symptomatic phases of infection in potato tubers inoculated with Dickeya solani

Iman Hadizadeh, Bahram Peivastegan, Jinhui Wang, Nina Sipari, Kåre Lehmann Nielsen, Minna Pirhonen and Haitao Shi

PLoS ONE, 2022, 17, e0273481
DOI: 10.1371/journal.pone.0273481

Evaluation of in vivo and in vitro efficacy of solasonine/solamargine-loaded lipid-polymer hybrid nanoparticles against bladder cancer

Ivana Pereira Santos Carvalho, Letícia Bueno Silva, Robson Luis Ferraz do Amaral, Tais Nader Chrysostomo-Massaro, Bruna Dias de Lima Fragelli, Joice Margareth de Almeida Rodolpho, Fernanda de Freitas Anibal, Ricardo Carneiro Borra, Jonas Augusto Rizzato Paschoal, Mariza Abreu Miranda, Jairo Kenupp Bastos, Fabíola Attié de Castro and Priscyla Daniely Marcato

International Journal of Pharmaceutics, 2024, 661, 124411
DOI: 10.1016/j.ijpharm.2024.124411

A noncanonical scaffold in steroidal metabolism

Guo Li, Huiqing He and Qiao Zhao

Trends in Plant Science, 2025, 30, 690
DOI: 10.1016/j.tplants.2025.03.008

Advances in the Biosynthesis and Molecular Evolution of Steroidal Saponins in Plants

Yi Li, Huan Yang, Zihao Li, Song Li and Jiaru Li

IJMS, 2023, 24, 2620
DOI: 10.3390/ijms24032620

Ontogeny and organ‐specific steroidal glycoside diversity is associated with differential expression of steroidal glycoside pathway genes in two Solanum dulcamara leaf chemotypes

R. A. Anaia, I. Chiocchio, R. Sontowski, B. Swinkels, F. Vergara and N. M. van Dam

Plant Biol J, 2025, 27, 651
DOI: 10.1111/plb.13704

Molecular Insights into the Role of Sterols in Microtuber Development of Potato Solanum tuberosum L.

Lisset Herrera-Isidron, Eliana Valencia-Lozano, Braulio Uribe-Lopez, John Paul Délano-Frier, Aarón Barraza and José Luis Cabrera-Ponce

Plants, 2024, 13, 2391
DOI: 10.3390/plants13172391

In silico analysis of rhamnosidase-mediated steroidal glycoalkaloid detoxification by Phytophthora infestans in potato (Solanum tuberosum L.)

Hammad Ahmed Abbasi, Fernando Berton Zanchi and Usman Arif

In Silico Research in Biomedicine, 2026, 2, 100255
DOI: 10.1016/j.insi.2026.100255

Key players in plant defense: How scaffold protein GAME15 orchestrates the biosynthesis of steroidal defense metabolite

Shengmei Kang and Feng Wang

Advanced Agrochem, 2025, 4, 10
DOI: 10.1016/j.aac.2024.11.008

Functional phytochemicals in tomatoes: biosynthesis, gene regulation, and human health implications

Essam ElShamey, Yawen Zeng, Yumei Ding and Jiazhen Yang

Front. Plant Sci., 2025, 16
DOI: 10.3389/fpls.2025.1662388

A tomato a day keeps the beetle away – the impact of Solanaceae glycoalkaloids on energy management in the mealworm Tenebrio molitor

Magdalena Joanna Winkiel, Szymon Chowański, Karolina Walkowiak-Nowicka, Marek Gołębiowski and Małgorzata Słocińska

Environ Sci Pollut Res, 2024, 31, 58581
DOI: 10.1007/s11356-024-35099-4

A comprehensive approach to the monitoring of steroidal glycoalkaloids in foods of plant origin

Anna Topolewska and Łukasz P. Haliński

Food Chemistry, 2024, 457, 140091
DOI: 10.1016/j.foodchem.2024.140091

Plant specialized metabolites in the rhizosphere of tomatoes: secretion and effects on microorganisms

Masaru Nakayasu, Kyoko Takamatsu, Kazufumi Yazaki and Akifumi Sugiyama

Bioscience, Biotechnology, and Biochemistry, 2022, 87, 13
DOI: 10.1093/bbb/zbac181

Analytical strategies by liquid chromatography for the determination of glycoalkaloids in potatoes, tomatoes, eggplants and related products: Current knowledge, applications, and future perspectives

Isabel Martínez-García, Sonia Morante-Zarcero and Isabel Sierra

Food Chemistry, 2026, 499, 147259
DOI: 10.1016/j.foodchem.2025.147259

De Novo Domestication Concept for Potato Germplasm Enhancement

Anastasiya A. Egorova, Nadezhda A. Chalaya, Ivan N. Fomin, Alisa I. Barchuk and Sophia V. Gerasimova

Agronomy, 2022, 12, 462
DOI: 10.3390/agronomy12020462

Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana

Sachin A. Gharat, Adam Jozwiak, Ilana Rogachev, Elinor A. Sharon, Sagit Meir, Ashok P. Giri and Asaph Aharoni

Plant Biotechnology Journal, 2026, 24, 328
DOI: 10.1111/pbi.70213

Haplotype-resolved genome of hexaploid Solanum nigrum: Insights into origin, evolution, and steroidal glycoalkaloid biosynthesis

Bo Kong, Xiaoxu Li, Zhenchen Zhang, Wei Luo and Yunpeng Cao

Cell Reports, 2026, 45, 117037
DOI: 10.1016/j.celrep.2026.117037

In Vitro Screening and Field Performance of EMS-Treated Eggplants for the Selection of Shoot and Fruit Borer-Resistant Plants

Md Ashraful Islam, Md Muntasir Bin Mohi Uddin, Md Golam Rasul, Md Ahsanul Haque Swapon, Minhaz Ahmed and Mehfuz Hasan

Agronomy, 2022, 12, 1832
DOI: 10.3390/agronomy12081832

The fate of a Solanum steroidal alkaloid toxin in the cabbage looper (Trichoplusia ni)

Tobias Ziemke, Ping Wang and Christophe Duplais

Insect Biochemistry and Molecular Biology, 2024, 175, 104205
DOI: 10.1016/j.ibmb.2024.104205

New Solasodine‐Type Glycoalkaloids Isolated from Solanum nigrum and Their Cytotoxic Activity

Bui Thi Thuy Luyen and Bui Thi Thu Trang

Chemistry & Biodiversity, 2024, 21
DOI: 10.1002/cbdv.202400872

Eggplant-derived Solamargin-Propolis nanoformulation as an efficacious chemotherapeutic agent for lung carcinoma A549 through mitochondrial dynamics dysregulation

Aeshah A. Awaji and Khulud M. Alshehri

Journal of Drug Delivery Science and Technology, 2025, 106, 106687
DOI: 10.1016/j.jddst.2025.106687

Toxic compounds and antinutritional factors in foods: a review

Jose Armando Narvaez-Padilla, Gerardo Díaz-Godínez, Moisés Eluzaí Rodríguez-Requenes and Rubén Díaz

FMR, 2026, 6, 0
DOI: 10.48130/fmr-0026-0004

Bioaccessibility and Antioxidant Capacity of Alkaloids from Microencapsulated Extract of Eggplant (Solanum melongena L.) Biomass

Brianda Giselle Germán-Soto, José Basilio Heredia, Nayely Leyva-López, Erick Paul Gutiérrez-Grijalva, Melissa García-Carrasco, Pedro de Jesús Bastidas-Bastidas and Laura Aracely Contreras-Angulo

Horticulturae, 2024, 10, 1242
DOI: 10.3390/horticulturae10121242

SlbHLH127 redirects metabolic flux into tomato steroidal glycoalkaloid biosynthesis via directly activates SlGAME4 and SlGAME12

Lu Zhou, Ruixi Gao, Jiayi Chen, Yulin Huang, Hsihua Wang, Yan Li, Yang Zhang and Feng Bai

The Plant Journal, 2026, 125
DOI: 10.1111/tpj.70797

A genomic variation map provides insights into potato evolution and key agronomic traits

Qun Lian, Yingying Zhang, Jinzhe Zhang, Zhen Peng, Weilun Wang, Miru Du, Hongbo Li, Xinyan Zhang, Lin Cheng, Ran Du, Zijian Zhou, Zhenqiang Yang, Guohui Xin, Yuanyuan Pu, Zhiwen Feng, Qian Wu, Guochao Xuanyuan, Shunbuer Bai, Rong Hu, Sónia Negrão, Glenn J. Bryan, Christian W.B. Bachem, Yongfeng Zhou, Ruofang Zhang, Yi Shang, Sanwen Huang, Tao Lin and Jianjian Qi

Molecular Plant, 2025, 18, 570
DOI: 10.1016/j.molp.2025.01.016

Metabolomic and transcriptomic analyses identify external conditions and key genes underlying high levels of toxic glycoalkaloids in tubers of stress-sensitive potato cultivars

Irene Merino, Alexandra Olarte Guasca, Ales Krmela, Usman Arif, Ashfaq Ali, Erik Westerberg, Siddhi Kashinanth Jalmi, Jana Hajslova, Vera Schulzova and Folke Sitbon

Front. Plant Sci., 2023, 14
DOI: 10.3389/fpls.2023.1210850

Analysis of glycoalkaloid distribution in the tissues of mealworm larvae (Tenebrio molitor)

Magdalena Joanna Winkiel, Szymon Chowański, Maria Sulli, Gianfranco Diretto and Małgorzata Słocińska

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-67258-5

Identification and Characterization of the Tomato UGT Gene Family and Effects of GAME 17 Overexpression on Plants and Growth and Development under High-CO2 Conditions

Shao-Wen Zheng, Zhi-Feng Chen, Ting-Ting Liu, Zi-Yao Zhao, Tian-Meng Li and Guo-Ming Xing

Agronomy, 2022, 12, 1998
DOI: 10.3390/agronomy12091998

Recent advances in steroidal glycoalkaloid biosynthesis in the genus Solanum

Ryota Akiyama, Naoyuki Umemoto and Masaharu Mizutani

Plant Biotechnology, 2023, 40, 185
DOI: 10.5511/plantbiotechnology.23.0717b

Regulation of Steroidal Alkaloid Biosynthesis in Bulbs of Fritillaria thunbergii Miq. By Shading and Potassium Application: Integrating Transcriptomics and Metabolomics Analyses

Jia Liu, Zixuan Zhu, Leran Wang, Qiang Yuan, Honghai Zhu, Xiaoxiao Sheng, Kejie Zhang, Bingbing Liang, Huizhen Jin, Shumin Wang, Wenjun Weng, Hui Wang and Ning Sui

Biology, 2025, 14, 633
DOI: 10.3390/biology14060633

Solanaceae IX: Systematics, genomics, and evolution

Tiina Särkinen, Rocio Deanna and Leandro Giacomin

TAXON, 2026, 75
DOI: 10.1002/tax.13277

Molecular Networks as Strategy for Dereplication of Steroidal Alkaloids of Herbarium Samples of Solanum jabrense Agra and M. Nee, an Endemic and Unexplored Species

Anauara Lima e Silva, Thiago Araújo de Medeiros Brito, Maria de Fátima Agra, Marcelo Sobral da Silva and Josean Fechine Tavares

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202402513

Agri-Food Waste Recycling for Healthy Remedies: Biomedical Potential of Nutraceuticals from Unripe Tomatoes (Solanum lycopersicum L.)

Vincenzo Piccolo, Arianna Pastore, Maria Maisto, Niloufar Keivani, Gian Carlo Tenore, Mariano Stornaiuolo and Vincenzo Summa

Foods, 2024, 13, 331
DOI: 10.3390/foods13020331

Potato Berries as a Valuable Source of Compounds Potentially Applicable in Crop Protection and Pharmaceutical Sectors: A Review

Marília Bueno da Silva, Anika Wiese-Klinkenberg, Björn Usadel and Franziska Genzel

J. Agric. Food Chem., 2024, 72, 15449
DOI: 10.1021/acs.jafc.4c03071

Glycoalkaloid‐Free Starch Potatoes Generated by CRISPR/Cas9‐Mediated Mutations of Genes in the Glycoalkaloid Biosynthesis Pathway Enable More Sustainable Uses of By‐Products From Starch Production

Ying Liu, Irene Merino, Mareike Gutensohn, Annika I. Johansson, Kalle Johansson, Mariette Andersson, Per Hofvander and Folke Sitbon

Plant Biotechnology Journal, 2026, 24, 1344
DOI: 10.1111/pbi.70412

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review

Julien A. Delbrouck, Michael Desgagné, Christian Comeau, Kamal Bouarab, François Malouin and Pierre-Luc Boudreault

Molecules, 2023, 28, 4957
DOI: 10.3390/molecules28134957