Hemoglobin-loaded ZIF-8 nanoparticles functionalized with human serum albumin as stealth, stable, and biocompatible oxygen carriers

Despoina Douka, Arnau Dieste-Izquierdo, Clara Coll-Satue, Eva Jakljevič, Fernando Enrique Farfán-Esponda, Ana María Pablo Sainz-Ezquerra and Leticia Hosta-Rigau

Nanoscale Adv., 2025, 7, 8058
DOI: 10.1039/D5NA00677E

Metal–organic framework-based oxygen carriers with antioxidant activity resulting from the incorporation of gold nanozymes

Xiaoli Liu, Nency Patricio Domingues, Emad Oveisi, Clara Coll-Satue, Michelle Maria Theresia Jansman, Berend Smit and Leticia Hosta-Rigau

Biomater. Sci., 2023, 11, 2551
DOI: 10.1039/D2BM01405J

Hemoglobin-loaded ZIF-8 nanoparticles equipped with PEGylated metal-phenolic network coatings: an oxygen carrier with antioxidant and stealth properties

Clara Coll-Satue, Eva Cabrera-San Millan, Michelle Maria Theresia Jansman, Lisa Arnholdt and Leticia Hosta-Rigau

J. Mater. Chem. B, 2025, 13, 3374
DOI: 10.1039/D4TB01771D

Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential

Xingli Cun, Michelle M. T. Jansman, Xiaoli Liu, Victor Boureau, Peter W. Thulstrup and Leticia Hosta-Rigau

RSC Adv., 2023, 13, 15540
DOI: 10.1039/D3RA00689A

Metal-Phenolic Networks as Broad-Spectrum Antioxidant Coatings for Hemoglobin Nanoparticles Working as Oxygen Carriers

Jiantao Chen, Xiaoli Liu, Michelle M. T. Jansman, Peter W. Thulstrup and Leticia Hosta-Rigau

Chem. Mater., 2022, 34, 9200
DOI: 10.1021/acs.chemmater.2c02190

In vitro and in vivo investigations of hemoglobin-loaded PEGylated ZIF-8 nanoparticles as oxygen carriers for emergency transfusion

Gizem Bor, Weiguang Jin, Despoina Douka, Neil Jean Borthwick, Xiaoli Liu, Michelle Maria Theresia Jansman and Leticia Hosta-Rigau

Biomaterials Advances, 2025, 168, 214118
DOI: 10.1016/j.bioadv.2024.214118

Metal–organic frameworks for the fabrication of hemoglobin-based oxygen carriers: A comprehensive review

Weiguang Jin, Ege Tini Tunca, Fernando Enrique Farfán-Esponda and Leticia Hosta-Rigau

Advances in Colloid and Interface Science, 2026, 353, 103857
DOI: 10.1016/j.cis.2026.103857

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Jing Shen, Guobo Chen, Linghao Zhao, Guoyang Huang, Hui Liu, Baolin Liu, Yuqing Miao and Yuhao Li

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300089

Hemoglobin-based oxygen carriers camouflaged with membranes extracted from red blood cells: Optimization and assessment of functionality

Michelle Maria Theresia Jansman, Clara Coll-Satue, Xiaoli Liu, Paul Joseph Kempen, Thomas Lars Andresen, Peter Waaben Thulstrup and Leticia Hosta-Rigau

Biomaterials Advances, 2022, 134, 112691
DOI: 10.1016/j.msec.2022.112691

Polydopamine-Coated Kaempferol-Loaded MOF Nanoparticles: A Novel Therapeutic Strategy for Postoperative Neurocognitive Disorder

Enhao Huang, Huadao Li, Hanghang Han, Lianshan Guo, Yubing Liang, Zijin Huang, Ke Qin and Xueke Du

IJN, 2024, Volume 19, 4569
DOI: 10.2147/IJN.S455492

A novel PEG-mediated approach to entrap hemoglobin (Hb) within ZIF-8 nanoparticles: Balancing crystalline structure, Hb content and functionality

Clara Coll-Satue, Marta Rubio-Huertas, Aurelie Ducrot, Evita Norkute, Xiaoli Liu, Fatmah Mish Ebrahim, Berend Smit, Peter Waaben Thulstrup and Leticia Hosta-Rigau

Biomaterials Advances, 2024, 163, 213953
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Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation

Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi and Leticia Hosta-Rigau

Biomaterials Advances, 2024, 156, 213698
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Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice

Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen and Xi Li

APL Materials, 2025, 13
DOI: 10.1063/5.0247728

Hemoglobin based oxygen carrier and its application in biomedicine

Luoming Liu, Kun Hou, Siyu Lin, Yaoxuan Di, Zhulun Zhuang, Ziyuan Zeng, Ying Sun, Chong Ji, Chaobo Huang and Ranhua Xiong

Coordination Chemistry Reviews, 2025, 532, 216508
DOI: 10.1016/j.ccr.2025.216508

Optimization and Investigation of Hemoglobin‐Loaded ZIF‐90 Metal–Organic Framework Nanoparticles as Artificial Oxygen Carriers

Despoina Douka, Weiguang Jin, Carlos Cantallops‐Iglesias, Arnau Dieste‐Izquierdo, Peter Waaben Thulstrup and Leticia Hosta‐Rigau

Part & Part Syst Charact, 2025, 42
DOI: 10.1002/ppsc.202400189

MXene-based anti-corrosive coatings: From physical barrier to active corrosion protection

Yonglong Zhang, Yue Yin, Jie Li, Feiyan Yang, Lingjing Meng, Yunfei Cai, Jinfang Wu, Fang Guo and Wenbo Wang

Progress in Organic Coatings, 2025, 204, 109225
DOI: 10.1016/j.porgcoat.2025.109225

Structural and functional alterations of polydopamine-coated hemoglobin: New insights for the development of successful oxygen carriers

Mohammadsadegh Nadimifar, Hedayatollah Ghourchian, Leticia Hosta-Rigau and Ali A. Moosavi-Movahedi

International Journal of Biological Macromolecules, 2023, 253, 127275
DOI: 10.1016/j.ijbiomac.2023.127275

Restoring normoxia in hypoxic cancer cells via hemoglobin-loaded MOF nanoparticles

Eva Jakljevič, Gizem Bor, Lisa Arnholdt, Clara Coll-Satue and Leticia Hosta-Rigau

International Journal of Biological Macromolecules, 2025, 333, 148520
DOI: 10.1016/j.ijbiomac.2025.148520

Biorthogonal PEGylation of Hierarchical Porous Metal–Organic Frameworks as Robust, Functional Nanocarriers for Hemoglobin-Based Oxygen Delivery

Weiguang Jin, Gizem Bor, Mehrdad Asgari, Louise Bochsen, Katrine Qvortrup, Anne Kirstine Havnsøe Krogh, David Fairen-Jimenez and Leticia Hosta-Rigau

J. Am. Chem. Soc., 2025, 147, 43400
DOI: 10.1021/jacs.5c10582