Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota

Wei Huang, Hui Chen, Qi He, Weidang Xie, Zanlin Peng, Qiang Ma, Qiaobing Huang, Zhongqing Chen and Yanan Liu

Food Funct., 2023, 14, 7692
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4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling

Lujun Xu, Juan Cai, Chenrui Li, Ming Yang, Tongyue Duan, Qing Zhao, Yiyun Xi, Liya Sun, Liyu He, Chengyuan Tang and Lin Sun

Mol Med, 2023, 29
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Differentiating Tangerine Peels from Other Citrus reticulata through GC-MS, UPLC-Q-Exactive Orbitrap-MS, and HPLC-PDA

Ziyang Song, Jiepei Xu, Jingyuan Tian, Jinji Deng, Xiaojing Deng, Mengdie Peng, Wenhui Luo, Minyan Wei, Yongmei Li and Guodong Zheng

ACS Omega, 2025, 10, 1688
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Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway

Xiaotong Huang, Xiaoxing Kou, Ting Zhan, Guokun Wei, Feinan He, Xueli Mao and Haidi Yang

Stem Cell Res Ther, 2023, 14
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Natural products that alleviate depression: The putative role of autophagy

Yunfeng Zhou, Fengwei Nan, Qianwen Zhang, Wangjun Xu, Shaojie Fang, Ke Liu, Bingxin Zhao, Hao Han, Xinmei Xie, Changjiang Qin and Xiaobin Pang

Pharmacology & Therapeutics, 2024, 264, 108731
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The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

Jie Zhang, Meiling Fan, Xia Yu and Bin Zhang

Pharmaceutical Biology, 2021, 59, 1526
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Nobiletin Ameliorates Aging of Chicken Ovarian Prehierarchical Follicles by Suppressing Oxidative Stress and Promoting Autophagy

Jingchun Bai, Xinyu Wang, Yiqiu Chen, Qiongyu Yuan, Zhaoyu Yang, Yuling Mi and Caiqiao Zhang

Cells, 2024, 13, 415
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Discussion on the mechanism of Tiaoqi Xiaowei decoction in the treatment of chronic atrophic gastritis based on network pharmacology and molecular docking: An observational study

Ruwen Yang, Jun Ouyang, Jiawei Jiang, Yuanpei Zhao, Defeng Wu, Dongmei Chen and Biao Xi

Medicine, 2024, 103, e38224
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Human Amniotic Epithelial Stem Cells Activate Autophagy via the IL-6/STAT3/FOXO3a Pathway to Facilitate Liver Regeneration Following Hepatectomy

Wenzhi Shu, Yisu Song, Zhengyang L. Lu, Renyi Su, Mengfan Yang, Ze Xiang, Chenhao Xu, Shusen Zheng, Xiao Xu and Xuyong Wei

CSCR, 2025, 20, 685
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Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice

Zuomin Hu, Zhongxing Chu, Xuke Ling, Yuchi Wu, Dandan Qin, Feiyan Yang, Xudong Yu, Yaping Zhou, Yiping Tang and Feijun Luo

Food Bioscience, 2024, 62, 105066
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Flavonoids and their role in oxidative stress, inflammation, and human diseases

Klaudia Jomova, Suliman Y. Alomar, Richard Valko, Jan Liska, Eugenie Nepovimova, Kamil Kuca and Marian Valko

Chemico-Biological Interactions, 2025, 413, 111489
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The Anti-Inflammatory Mechanism of Flaxseed Linusorbs on Lipopolysaccharide-Induced RAW 264.7 Macrophages by Modulating TLR4/NF-κB/MAPK Pathway

Jialong Li, Jing Chen, Ping Huang, Zizhe Cai, Ning Zhang, Yong Wang and Ying Li

Foods, 2023, 12, 2398
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In vitro antioxidant analysis of flavonoids extracted from Artemisia argyi stem and their anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophages

Zichao Wang, Lu Wang, Hongtao Huang, Qiuyan Li, Xiaoyuan Wang, Qi Sun, Qi Wang and Na Li

Food Chemistry, 2023, 407, 135198
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Antioxidant and anti-inflammatory activity through inhibition of NF-κB and sEH of some citrus peel and phytoconstituent characteristics

Yesi Desmiaty, Ni Made Dwi Sandhiutami, Esti Mulatsari, Farah Alida Maziyah, Kartika Rahmadhani, Hanif Omar Zidane Algifari and Fernanda Alif Jantuna

Saudi Pharmaceutical Journal, 2024, 32, 101959
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Potential and Mechanism of Nobiletin in Diabetes Mellitus and Associated Complications

Chuyun Zhao, Wenjie Lai, Yu Li, Kinfong Hong and Youhua Xu

Pharmaceuticals, 2025, 18, 1528
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Orientin Alleviates Liver Inflammation via Downregulation of ZEB-2/PTEN Markers—Hepatic Stellate Cells Approach

Hany Ezzat Khalil, Hairul-Islam Mohamed Ibrahim, Kareem Ahmed El-Fass, Sabah H. Akrawi and Mohamed A. Morsy

Applied Sciences, 2022, 12, 2725
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The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites

Jingxuan Ma, Ru Wang, Yaping Xu, Yan Wang, Zixuan Liu, Zhaoxia Wu and Yuanyuan Bian

Nutrients, 2025, 17, 3498
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Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats

Tianwen Ma, Liangyu Lv, Yue Yu, Lina Jia, Xiaopeng Song, XinYu Xu, Ting Li, Xuanbo Sheng, Haoran Wang, Jiantao Zhang and Li Gao

Front. Pharmacol., 2022, 13
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Recent advances in the therapeutic potential of nobiletin against respiratory diseases

Yanqin Qin, Jingfan Yang, Haibo Li and Jiansheng Li

Phytomedicine, 2024, 128, 155506
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Spatial Distribution and Antioxidant Activity of Extracts from Citrus Fruits

María García-Nicolás, Carlos A. Ledesma-Escobar and Feliciano Priego-Capote

Antioxidants, 2023, 12, 781
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Mechanism of miR-125b-5p Carried with Albumin Nanoparticles in Protecting the Injured Nerve Cells in Ischemia-Reperfusion Cerebral Injury

Chao Lv, Yanwei Chen, Liping Liu and Zhao Jiang

j biomed nanotechnol, 2023, 19, 943
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Nobiletin, an active component of Wenyang Yiqi formula, alleviates constipation associated depression through targeting MAPT to inhibit the MAPK signaling pathway

Qing Zhou, Zongqi He, Shuai Yan, Xiaopeng Wang and Bensheng Wu

Phytomedicine, 2024, 126, 155203
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Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD)

Qiqi Ran, Qianrong Gan, Ye Zhu, Li Song, Longyu Shen, Xinyi Duan, Xinyun Zhu and Wei Huang

Biomedicine & Pharmacotherapy, 2024, 173, 116322
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Regulation of autophagy and cellular signaling through non-histone protein methylation

Yongfen Bao, Yaoyao Ma, Wentao Huang, Yujie Bai, Siying Gao, Luyao Xiu, Yuyang Xie, Xinrong Wan, Shigang Shan, Chao Chen and Lihua Qu

International Journal of Biological Macromolecules, 2025, 291, 139057
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Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Shankar Prasad Sha, Debabrata Modak, Sourav Sarkar, Sudipta Kumar Roy, Sumit Prasad Sah, Kriti Ghatani and Soumen Bhattacharjee

Front. Microbiol., 2023, 14
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Pharmacology-Driven Dissection of Core Component Sets of Xuefu Zhuyu Decoction in Blood Stasis-Related Cardiovascular Diseases

Xuyang Dai, Dongsheng Ba, Miansheng Gao, Chen Liang, Ximeng Zhang, Huijuan Yu, Xin Chai and Yuefei Wang

Pharmaceuticals, 2026, 19, 532
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Nobiletin Regulates Lysosome Function in Bovine Endometrial Epithelial Cells

Karen Koshimizu, Ren Ozawa, Sohei Kuribayashi, Maho Taru, Hisataka Iwata, Ryotaro Miura, Seizo Hamano and Koumei Shirasuna

Dairy, 2024, 5, 754
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The rules and regulatory mechanisms of FOXO3 on inflammation, metabolism, cell death and aging in hosts

Guoding Cao, Monan Lin, Wei Gu, Zaiyu Su, Yagan Duan, Wuqi Song, Hailiang Liu and Fengmin Zhang

Life Sciences, 2023, 328, 121877
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Study on the mechanism of the Chinese herbal pair Banxia-Chenpi in ameliorating polycystic ovary syndrome based on the CYP17A1 gene

Can Shen, Haotian Li, Min Xiao, Xiaocui Jiang, Jing Jin, Jiayan Zhou, Bin Xiong, Yu Chen and Min Zhao

Journal of Ethnopharmacology, 2025, 344, 119503
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The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-κB

Taisuke Murata, Sho Ishiwa, Xin Lin, Yosuke Nakazawa, Kenji Tago and Megumi Funakoshi-Tago

Neurochemistry International, 2023, 171, 105613
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Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile

Irlã Santos Lima, Érica Novaes Soares, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Balbino Lino dos Santos and Silvia Lima Costa

Brain Sciences, 2024, 14, 90
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Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis

Dan Shao, Wenxiang Shen, Yuyang Miao, Zhen Gao, Menghao Pan, Qiang Wei, Zuoting Yan, Xiaoe Zhao and Baohua Ma

J Animal Sci Biotechnol, 2023, 14
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Nobiletin Alleviates Astrocyte Activation and Oxidative Stress Induced by Hypoxia In Vitro

Dandan Wang, Fengjuan Gao, Fangyuan Hu and Jihong Wu

Molecules, 2022, 27, 1962
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Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization

Si-wei Wang, Tian Lan, Hao Sheng, Fang Zheng, Mei-kang Lei, Li-xia Wang, Hang-fei Chen, Chun-yi Xu and Feng Zhang

Front. Physiol., 2021, 12
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Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy

Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda and Minoru Tsuji

Experimental Neurology, 2024, 373, 114671
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Agarotetrol alleviates reflux esophagitis by regulating autophagy through the METTL14/FOXO3a pathway

Xi Chen, Yeqing Yu, Xiangxiang Xu, Haifeng Lan, Jiaxin Li, Jing Zuo, Kejin Li, MinFen Zhang, Ji Xuan and Hui Li

European Journal of Pharmacology, 2025, 1008, 178270
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Revealing the potential bioactive components and mechanism of Qianhua Gout Capsules in the treatment of gouty arthritis through network pharmacology, molecular docking and pharmacodynamic study strategies

Gelin Xiang, Luyin Yang, Jing Qin, Shaohui Wang, Yi Zhang and Sijin Yang

Heliyon, 2024, 10, e30983
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Anti-inflammatory and protective effects of Pimpinella candolleana on ulcerative colitis in rats: a comprehensive study of quality, chemical composition, and molecular mechanisms

Xiaoqi Liu, Hai Xiao, Mingxia Luo, Junpeng Meng, Lin Zhong, Tao Wu, Yongxia Zhao, Faming Wu and Jian Xie

Front. Pharmacol., 2024, 15
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Nobiletin promotes fracture healing by modulating macrophage polarization: a review

Zhiqi Zhang, Shangyi Liu, Wenhao Li and Kangquan Shou

Front. Pharmacol., 2026, 16
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Antioxidants from different citrus peels provide protection against cancer

Nouf Khalifa ALaqeel

Braz. J. Biol., 2024, 84
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Nobiletin‐mediated autophagy mitigates nanoplastic‐induced toxicity in human intestinal Caco‐2 cells

Junho Yu, Ji‐Hwan Yoon, Miey Park and Hae‐Jeung Lee

The FASEB Journal, 2025, 39
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The draft genome and multi-omics analyses reveal new insights into geo-herbalism properties of Citrus grandis ‘Tomentosa’

Lin Xian, Sunil Kumar Sahu, Liying Huang, Yannan Fan, Jianhao Lin, Jianmu Su, Mei Bai, Yewen Chen, Shujie Wang, Peng Ye, Fang Wang, Qun Luo, Haiyi Bai, Xiaojing Lin, Caihong Yuan, Xiaodie Geng, Huan Liu and Hong Wu

Plant Science, 2022, 325, 111489
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Phytochemical Compounds as Promising Therapeutics for Intestinal Fibrosis in Inflammatory Bowel Disease: A Critical Review

Aya A. Touny, Balaji Venkataraman, Shreesh Ojha, Mauro Pessia, Veedamali S. Subramanian, Shamanth Neralagundi Hariharagowdru and Sandeep B. Subramanya

Nutrients, 2024, 16, 3633
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Evaluation of the authenticity of Citri Grandis Exocarpium based on metabolomics and transcriptomics

Haiting Huang, Yu Liu, Jianmu Su, Xiangxiu Liang, Hong Wu and Mei Bai

M, 2025, 4, 0
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Antiradical Activity Studies of Ultrasound-Assisted Extraction of Total Flavonoids from Sanghuangporus vaninii Fruit Bodies

Guo Lin, Xin Dou, NengBin Gao, DianJie Hu, Lihong Zhang and Rotimi Aluko

Journal of Food Biochemistry, 2023, 2023, 1
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Suzi Daotan Decoction alleviates asthmatic airway remodeling through the AMPK/SIRT1/PGC-1α signaling pathway and PI3K/AKT signaling pathway

Kaiyue Liu, Ruobai Liu, Chenghao Zhang, Dandan Huang, Bowen Wei, Yilan Song, Chongyang Wang, Xin Zhang, Mingyu Zheng and Guanghai Yan

Sci Rep, 2025, 15
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Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism

Biao Qu, Shimin Wang, Hailan Zhu, Tianpeng Yin, Renpeng Zhou, Wei Hu and Chao Lu

ACS Omega, 2023, 8, 2586
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Efficacy of Jiinshihoto on Depressive Symptoms in Patients With Pulmonary Mycobacterium avium-intracellulare Complex Disease not Receiving Standard Treatment

Makiko Yamaguchi, Keiko Ogawa-Ochiai, Tadashi Toyama, Kosuke Kurokawa, Toshihiro Takeda, Masayuki Sato, Miho Mitsui, Akikazu Shimada, Tomoaki Sonoda, Chisato Honjo, Maiko Kadowaki, Yukihiro Umeda, Tamotsu Ishizuka and Yuko Waseda

Global Advances in Integrative Medicine and Health, 2026, 15
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Dietary Methylglyoxal Exposure Induces Alzheimer’s Disease by Promoting Amyloid β Accumulation and Disrupting Autophagy in Caenorhabditis elegans

Chia-Cheng Wei, Shang-Wei Li, Chia-Tung Wu, Chun Ming How and Min-Hsiung Pan

J. Agric. Food Chem., 2022, 70, 10011
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Anti-Inflammatory Activity of the Combination of Nobiletin and Docosahexaenoic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells: A Potential Synergistic Anti-Inflammatory Effect

Kosuke Nishi, Yuki Nakatani, Momoko Ishida, Ayumu Kadota and Takuya Sugahara

Nutrients, 2024, 16, 2080
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Potential Mechanisms for Shenling Baizhu Powder in the Treatment of MAFLD Based on Network Pharmacology and Experimental Validation

Anni Zheng, Sufei Song, Qiuling Xu and Tao Liu

Natural Product Communications, 2025, 20
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Nobiletin Regulates Polyinosinic-polycytidylic Acid-induced Inflammation in Macrophages Partially via the PPAR-γ Signaling Pathway

Ying-Xing Yue, Shan-Shan Huang, Ying-Zheng Weng, Yan Lu, Bing-Bing Jia and Zhou-Xin Yang

CPD, 2024, 30, 2937
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Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy

Bo Liu, Zhiyuan Cai, Yan Wang, Xinye Liu, Bin Zhang, Qian Zheng, Jingye Li, Cien Li, Yuanbo Cui, Pengju Lv and Dongwei Yang

Front. Pharmacol., 2024, 15
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A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation

Ignazio Restivo, Manuela Giovanna Basilicata, Ilenia Concetta Giardina, Alessandro Massaro, Giacomo Pepe, Emanuela Salviati, Camilla Pecoraro, Daniela Carbone, Stella Cascioferro, Barbara Parrino, Patrizia Diana, Carmine Ostacolo, Pietro Campiglia, Alessandro Attanzio, Antonella D’Anneo, Fanny Pojero, Mario Allegra and Luisa Tesoriere

Antioxidants, 2023, 12, 1621
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In vitro and in vivo anti-osteoarthritis effects of tradition Chinese prescription Ji-Ming-San

Cheng-Yang Hsieh, Ching-Chiung Wang, Lemmuel L. Tayo, Shun-Xin Deng, Po-Wei Tsai and Chia-Jung Lee

Journal of Ethnopharmacology, 2023, 305, 116084
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Mechanisms of cancer cachexia and targeted therapeutic strategies

Long Li and Zhi-Qiang Ling

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2024, 1879, 189208
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Nobiletin ameliorates monosodium urate-induced gouty arthritis in mice by enhancing AMPK/mTOR-mediated autophagy to inhibit NF-κB/NLRP3 inflammasome activation

Zhiyong Liu, Aichun Chu, Zhiqian Bai and Chao Yang

Immunology Letters, 2025, 274, 106982
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Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Ramesh Kumar Saini, Arina Ranjit, Kavita Sharma, Parchuri Prasad, Xiaomin Shang, Karekal Girinur Mallikarjuna Gowda and Young-Soo Keum

Antioxidants, 2022, 11, 239
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