Issue 26, 2024

Predictive design of multimonomeric polyelectrolytes enables lung-specific gene delivery

Abstract

We present a class of programmable polymer nanoparticles capable of intravenous pDNA delivery with ∼350 000-fold enhancement of specificity to the lung by qPCR in mice. Molecular level insight of these polyelectrolytes is connected to bioperformance, exemplifying how robust, data-driven workflows can expedite synthesis/screening campaigns for gene therapy.

Graphical abstract: Predictive design of multimonomeric polyelectrolytes enables lung-specific gene delivery

Supplementary files

Article information

Article type
Communication
Submitted
21 feb. 2024
Accepted
16 may. 2024
First published
22 may. 2024

Polym. Chem., 2024,15, 2627-2633

Predictive design of multimonomeric polyelectrolytes enables lung-specific gene delivery

J. M. Ting, J. D. Fisher, T. Conyers, S. Patil, C. G. Robohn, T. Tamayo-Mendoza, F. Oviedo and S. K. Murthy, Polym. Chem., 2024, 15, 2627 DOI: 10.1039/D4PY00196F

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