Issue 8, 2024

Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Abstract

The majority of known peptides with high bioactivity (BAPs) such as antihypertensive, antidiabetic, antioxidant, hypocholesterolemic, anti-inflammatory and antimicrobial actions, are short-chain sequences of less than ten amino acids. These short-chain BAPs of varying natural and synthetic origin must be bioaccessible to be capable of being adsorbed systemically upon oral administration to show their full range of bioactivity. However, in general, in vitro and in vivo studies have shown that gastrointestinal digestion reduces BAPs bioactivity unless they are protected from degradation by encapsulation. This review gives a critical analysis of short-chain BAP encapsulation and performance with regard to the oral delivery route. In particular, it focuses on short-chain BAPs with antihypertensive and antidiabetic activity and encapsulation methods via nanoparticles and microparticles. Also addressed are the different wall materials used to form these particles and their associated payloads and release kinetics, along with the current challenges and a perspective of the future applications of these systems.

Graphical abstract: Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Article information

Article type
Review Article
Submitted
30 sep. 2023
Accepted
24 mar. 2024
First published
25 mar. 2024
This article is Open Access
Creative Commons BY license

Food Funct., 2024,15, 3959-3979

Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Y. Atma, B. S. Murray, A. Sadeghpour and F. M. Goycoolea, Food Funct., 2024, 15, 3959 DOI: 10.1039/D3FO04195F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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