Issue 9, 2024

Olive oil intake and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose–response meta-analysis of prospective cohort studies

Abstract

Background: Currently, the reported links between olive oil intake and cardiovascular disease (CVD), cancer morbidity and mortality, and all-cause mortality are inconsistent. The aim of this meta-analysis is to study the reported correlations of olive oil intake with CVD, coronary heart disease (CHD), stroke and cancer incidence and mortality, and all-cause mortality. Methods: PubMed, Embase, and Web of Science were searched until March 7, 2024. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were estimated by the random-effects model. Nonlinear dose–response relationships were modeled with restricted cubic splines. This study has been registered at PROSPERO (CRD42023419001). Results: Overall, 30 articles covering 2 710 351 participants were identified. Higher olive oil intake was linked with a reduced risk of CVD incidence (RR: 0.85; 95% CI: 0.77, 0.93), CHD incidence (RR: 0.85; 95% CI: 0.72, 0.99), CVD mortality (RR: 0.77; 95% CI: 0.67, 0.88), and all-cause mortality (RR: 0.85; 95% CI: 0.81, 0.89). For a 10 g d−1 increment of olive oil intake, the risk of CVD incidence, stroke incidence, CVD mortality, and all-cause mortality decreased by 7%, 5%, 8%, and 8%, respectively. No association was found between olive oil intake and cancer incidence and mortality. Nonlinear relationships between olive oil intake and CVD and all-cause mortality were observed, with a reduced risk from intakes ranging from 0 to 18 g d−1 and 0 to 22 g d−1, respectively. Conclusion: Our study found that high olive oil intake was related to a lower risk of CVD and CHD incidence and CVD mortality and all-cause mortality.

Graphical abstract: Olive oil intake and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose–response meta-analysis of prospective cohort studies

Supplementary files

Article information

Article type
Review Article
Submitted
28 nov. 2023
Accepted
19 mar. 2024
First published
20 mar. 2024

Food Funct., 2024,15, 4668-4681

Olive oil intake and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose–response meta-analysis of prospective cohort studies

Y. Ke, H. Fan, Y. Zhao, X. Fu, M. Wang, Y. Gao, Y. Chen, W. Huo, W. Zhang, L. Wang, Y. Wu, X. Li, D. Zhang, F. Hu, M. Zhang, L. Sun, J. Lu and D. Hu, Food Funct., 2024, 15, 4668 DOI: 10.1039/D3FO05246J

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