Themed collection Novel Antibiotics and Antimicrobial Resistance
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Editorial: Are natural products the solution to antimicrobial resistance?
Nat. Prod. Rep., 2017,34, 685-686
https://doi.org/10.1039/C7NP90026K
Opportunities for natural products in 21st century antibiotic discovery
Natural product research is poised to regain prominence in delivering new drugs to solve the antibiotic crisis.
Nat. Prod. Rep., 2017,34, 694-701
https://doi.org/10.1039/C7NP00019G
Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?
Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles.
Nat. Prod. Rep., 2017,34, 687-693
https://doi.org/10.1039/C7NP00011A
Proline-rich antimicrobial peptides targeting protein synthesis
Proline-rich antimicrobial peptides (PrAMPs) bind within the exit tunnel of the ribosome and inhibit translation elongation. Structures of ribosome-bound PrAMPs reveal the interactions with ribosomal components and could pave the way for the development of novel peptide-based antimicrobial agents.
Nat. Prod. Rep., 2017,34, 702-711
https://doi.org/10.1039/C7NP00020K
Antibiotics and specialized metabolites from the human microbiota
Human microbiota associated with each body site produce specialized molecules to kill human pathogens. Advanced bioinformatics tools will help to discover unique microbiome chemistry.
Nat. Prod. Rep., 2017,34, 1302-1331
https://doi.org/10.1039/C7NP00021A
Actinomycetes: still a source of novel antibiotics
An update on last ten years of actinomycetes antibiotic discovery, including recent key molecules in clinical development and overlooked compounds discovered using novel strategies.
Nat. Prod. Rep., 2017,34, 1203-1232
https://doi.org/10.1039/C7NP00026J
Targeting a cell wall biosynthesis hot spot
History points to the bacterial cell wall biosynthetic network as a very effective target for antibiotic intervention, and numerous natural product inhibitors have been discovered.
Nat. Prod. Rep., 2017,34, 909-932
https://doi.org/10.1039/C7NP00012J
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
Gram-negative bacteria are a rich and underexplored source of antibiotics that are assembled via remarkably diverse biosynthetic pathways.
Nat. Prod. Rep., 2017,34, 712-783
https://doi.org/10.1039/C7NP00010C
Recent advances and perspectives in the design and development of polymyxins
Polymyxins: background and future perspectives. Introducing metabolism and detoxification considerations into the design of new polymyxins to reduce nephrotoxicity.
Nat. Prod. Rep., 2017,34, 886-908
https://doi.org/10.1039/C7NP00023E
Symbiosis-inspired approaches to antibiotic discovery
Advances in our understanding of symbioses, enabled by newly developed “omics” and co-culturing technologies, inspire new approaches to antibiotic discovery.
Nat. Prod. Rep., 2017,34, 784-814
https://doi.org/10.1039/C7NP00009J
Bifunctional antimicrobial conjugates and hybrid antimicrobials
Novel antimicrobial drugs are continuously needed to counteract bacterial resistance development.
Nat. Prod. Rep., 2017,34, 832-885
https://doi.org/10.1039/C7NP00006E
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Conformational control of the bacterial Clp protease by natural product antibiotics
Natural products targeting the bacterial Clp protease unravel key interfaces for protein–protein–interaction and long-distance conformational control.
Nat. Prod. Rep., 2017,34, 815-831
https://doi.org/10.1039/C6NP00125D
About this collection
Natural Product Reports is delighted to publish a collection of reviews focussing on novel antibiotics and antimicrobial resistance. Guest Edited by Bradley S. Moore, Guy T. Carter and Mark Brönstrup, this collection brings insight into the role of natural products play in alleviating the increasing issue of antimicrobial resistance.