This review highlights the progress achieved in transition-metal (ruthenium, rhodium, iridium, and nickel) catalyzed asymmetric hydrogenation of unsaturated sulfones including substrate scopes, catalytic mechanisms, and applications.
The highly enantioselective hydrogenation of allylic sulfones catalyzed by Rh-(R,R)-f-spiroPhos for synthesis of chiral β-ester sulfones has been developed for the first time achieving high yields and excellent enantioselectivities (92–99.9% ee).
This review summarizes the recent advances (2016–2023) in the stereoselective metal-catalyzed hydrogenation of cyclic α,β-unsaturated ketones, lactams and lactones since considerable developments were made. Where possible the application of these methodologies in synthesis is outlined.
A green, one-pot sequential synthesis of functionalized quinolinones from benzhydrol is reported. This method features mild reaction conditions, high atom economy, scalability, and excellent yields. The photophysical properties were also explored.
An iridium-catalyzed asymmetric hydrogenation of 2-esteryl-5-hydroxypyridinium salts is reported, providing chiral cis-5-hydroxypiperidine-2-carboxylates in excellent yields with high levels of enantioselectivities and diastereoselectivities.