Since the aggregation-based emission (AIE) phenomenon emerged in 2001, numerous chemical designs have been built around the AIE concept, displaying its utility for diverse applications, including optics, electronics, energy, and biosciences.
The synthesis of a novel series of 32 dihydropyridine–triazole conjugates using click chemistry and their antitubercular activity, structure–activity relationship (SAR) analysis, and ADME predictions are discussed.
An efficient copper-catalyzed one-pot reaction, facilitated by TMEDA, enables the synthesis of 1,2-dihydroquinoline/chromene fused triazoles with varying sugar functionalities, providing moderate to good yields.
Triazolic TAM 9b, with its pronounced anticancer activity, highlight its potential as a promising drug candidate for the treatment of colorectal cancer.
A series of fused tetrahydrochromeno isoindole dione derivatives was successfully synthesized. In silico physicochemical, pharmacokinetic, and ADMET, UV-visible and fluorescence study of all synthesized compound has been carried out.