External ligand-free Pd-catalyzed arylation achieving an exclusive switch in regioselectivity from α- to β position of N-vinyl-7-azaindoles via an N-oxide activation strategy.
Dowtherm-A mediated facile synthesis of 2-aroyl 7-azaindoles via a hetereoannulation strategy.
Cancer remains a major global health challenge and a leading cause of mortality. This ongoing burden underscores the need for continuous exploration of novel therapeutic strategies, prompting extensive review of emerging targets, mechanisms, and treatment approaches.
A new synthetic route towards 6-azaindoles (pyrrolo[2,3-c]pyridines) and pyrrolo[2,3-d]pyridazines starting from 4-aroyl pyrroles is described.
This review presents various new strategies for the functionalization of 5 and 6-membered fused heteroaromatics. These synthetic strategies enable rapid access to complex heterocyclic compounds.