Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation

Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid and Mai Adel

RSC Med. Chem., 2024, 15, 3529
DOI: 10.1039/D4MD00481G

Phosphorus-nitrogen compounds: Part 79. Design and synthesis of spiro-bino-spiro (sbs)-bis (tetraalkylaminocyclotriphosphazenes) and novel twenty-membered bis(dichlorocyclotriphos-phaza)macrocycles: Structural analysis, chirality and bioactivity studies

Reşit Cemaloğlu, Nuran Asmafiliz, Tuncer Hökelek, Zeynel Kılıç, Leyla Açık, Büşra Nur Sabah, Dila Koyunoğlu and Melis Özbük

Journal of Molecular Structure, 2025, 1335, 141926
DOI: 10.1016/j.molstruc.2025.141926

Innovative Multitarget Organoselenium Hybrids With Apoptotic and Anti‐Inflammatory Properties Acting as JAK1/STAT3 Suppressors

Saad Shaaban, Aya Yaseen Mahmood Alabdali, Mai H. A. Mousa, Hussein Ba‐Ghazal, Yasair S. Al‐Faiyz, Ibrahim Elghamry, Hanan A. Althikrallah, Arwa Omar Al Khatib, Mohamed Alaasar and Ahmed A. Al‐Karmalawy

Drug Development Research, 2025, 86
DOI: 10.1002/ddr.70075

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments

Salma M. Hefny, Tarek F. El-Moselhy, Nabaweya El-Din, Andrea Ammara, Andrea Angeli, Marta Ferraroni, Ahmed M. El-Dessouki, Moataz A. Shaldam, Galal Yahya, Ahmed A. Al-Karmalawy, Claudiu T. Supuran and Haytham O. Tawfik

European Journal of Medicinal Chemistry, 2024, 274, 116527
DOI: 10.1016/j.ejmech.2024.116527

Targeting DNA repair mechanisms: Spirobenzoxazinone and salicylamide derivatives as novel candidates for PARP-1 inhibition in cancer therapy

Alaa Ahmed Kadry, Mai Adel, Samar A. Abubshait, Galal Yahya, Marwa Sharaky, Rabah A.T. Serya and Khaled A.M. Abouzid

Bioorganic & Medicinal Chemistry, 2025, 124, 118173
DOI: 10.1016/j.bmc.2025.118173

Synthesis of thiazolidine-2,4-dione tethered 1,2,3-triazoles as α-amylase inhibitors: In vitro approach coupled with QSAR, molecular docking, molecular dynamics and ADMET studies

Rahul Singh, Jayant Sindhu, Meena Devi, Parvin Kumar, Sohan Lal, Ashwani Kumar, Devender Singh and Harish Kumar

European Journal of Medicinal Chemistry, 2024, 275, 116623
DOI: 10.1016/j.ejmech.2024.116623

Thiazole derivatives in cancer therapy: mechanistic insights, bioactivity, and future perspective

Honey Saini, Anuradha Mehra and Amit Mittal

Future Medicinal Chemistry, 2025, 17, 2021
DOI: 10.1080/17568919.2025.2550929