Development of Naturally Inspired Peptide and Protein Chemistry

Akira Otaka

Chem. Pharm. Bull., 2022, 70, 748
DOI: 10.1248/cpb.c22-00623

Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation

Hayate Shida, Akihiro Taguchi, Yuma Tokita, Yan Cui, Momoka Sakamaki, Sho Konno, Atsuhiko Taniguchi, Young Sook Yun, Yuuta Fujikawa, Hiroshi Kaneko, Hidemasa Nakaminami and Yoshio Hayashi

ChemistryEurope, 2025, 3
DOI: 10.1002/ceur.202500059

Sulfoxide‐Mediated Cys‐Trp‐Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization

Daishiro Kobayashi, Masaya Denda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, Kento Ohkawachi, Kiyomi Nigorikawa, Tetsuro Yoshimaru, Naozumi Ishimaru, Wataru Nomura, Toyomasa Katagiri, Hidetaka Kosako and Akira Otaka

ChemistryEurope, 2024, 2
DOI: 10.1002/ceur.202400014

Non-symmetric stapling of native peptides

Fa-Jie Chen, Wanzhen Lin and Fen-Er Chen

Nat Rev Chem, 2024, 8, 304
DOI: 10.1038/s41570-024-00591-5

S-Protected Cysteine Sulfoxide-Enabled Tryptophan-Selective Modification with Application to Peptide Lipidation

Daishiro Kobayashi, Eisuke Kuraoka, Junya Hayashi, Takuma Yasuda, Yutaka Kohmura, Masaya Denda, Norio Harada, Nobuya Inagaki and Akira Otaka

ACS Med. Chem. Lett., 2022, 13, 1125
DOI: 10.1021/acsmedchemlett.2c00161

Advanced Insulin Synthesis by One‐pot/Stepwise Disulfide Bond Formation Enabled by S‐Protected Cysteine Sulfoxide

Kota Hidaka, Daishiro Kobayashi, Junya Hayashi, Masaya Denda and Akira Otaka

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401003

Recent Advances in Chalcogenation of α‐Amino Acids/Peptides: Synthetic and Mechanistic Aspects

Raghunath Bag, Malobika Kar and Nagendra K. Sharma

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202400513

Mild Lewis-Acid-Promoted Cysteine–Tryptophan Conjugation Involving a Radical Process

Qingqing Lu, Hongyan Wen, Qinshuo Zhang, Zhou Zhang, Shiping Wang, Ruo Wang and Chunfa Xu

Org. Lett., 2025, 27, 6192
DOI: 10.1021/acs.orglett.5c01845