The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles

Yunlu Jiang, Maocai Yan, Chunmei Wang, Qinqin Wang, Xiaoyu Chen, Rumin Zhang, Lei Wan, Bingyuan Ji, Bo Dong, Huiyun Wang and Jing Chen

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.630548

A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

Peiran Yang, Cai Read, Rhoda E. Kuc, Duuamene Nyimanu, Thomas L. Williams, Alexi Crosby, Guido Buonincontri, Mark Southwood, Stephen J. Sawiak, Robert C. Glen, Nicholas W. Morrell, Anthony P. Davenport and Janet J. Maguire

British J Pharmacology, 2019, 176, 1206
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Apelinergic System Structure and Function

Kyungsoo Shin, Calem Kenward and Jan K. Rainey

Comprehensive Physiology, 2018, 8, 407
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Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure–Functional Selectivity Relationships (SFSRs) and Therapeutic Potential

Liang Tan, Wenzhong Yan, John D. McCorvy and Jianjun Cheng

J. Med. Chem., 2018, 61, 9841
DOI: 10.1021/acs.jmedchem.8b00435

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment

Élie Besserer-Offroy, Patrick Bérubé, Jérôme Côté, Alexandre Murza, Jean-Michel Longpré, Robert Dumaine, Olivier Lesur, Mannix Auger-Messier, Richard Leduc, Éric Marsault and Philippe Sarret

Pharmacological Research, 2018, 131, 7
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Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure

Wei Meng, Zulan Pi, Robert Brigance, Karen A. Rossi, William A. Schumacher, Jeffrey S. Bostwick, Peter S. Gargalovic, Joelle M. Onorato, Chiuwa E. Luk, Claudia N. Generaux, Tao Wang, Ruth R. Wexler and Heather J. Finlay

J. Med. Chem., 2021, 64, 18102
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Advances in therapeutic peptides targeting G protein-coupled receptors

Anthony P. Davenport, Conor C. G. Scully, Chris de Graaf, Alastair J. H. Brown and Janet J. Maguire

Nat Rev Drug Discov, 2020, 19, 389
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Targeting drugs to APJ receptor: From signaling to pathophysiological effects

Zhen Huang, Lu He, Zhe Chen and Linxi Chen

Journal Cellular Physiology, 2019, 234, 61
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A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects

Kien Trân, Alexandre Murza, Xavier Sainsily, David Coquerel, Jérôme Côté, Karine Belleville, Lounès Haroune, Jean-Michel Longpré, Robert Dumaine, Dany Salvail, Olivier Lesur, Mannix Auger-Messier, Philippe Sarret and Éric Marsault

J. Med. Chem., 2018, 61, 2266
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Rôle physiologique du récepteur de l’apéline : Implication dans le maintien de l’équilibre hydrique et de l’hyponatrémie

Pierre-Emmanuel Girault-Sotias, Nadia De Mota and Catherine Llorens-Cortès

Biologie Aujourd’hui, 2021, 215, 119
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Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects

Kien Tran, Xavier Sainsily, Jérôme Côté, David Coquerel, Pierre Couvineau, Sabrina Saibi, Lounès Haroune, Élie Besserer-Offroy, Joël Flynn-Robitaille, Martin Resua Rojas, Alexandre Murza, Jean-Michel Longpré, Mannix Auger-Messier, Olivier Lesur, Michel Bouvier, Éric Marsault, Pierre-Luc Boudreault and Philippe Sarret

J. Med. Chem., 2022, 65, 531
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The apelin/APJ system as a therapeutic target in metabolic diseases

Isabelle Castan-Laurell, Bernard Masri and Philippe Valet

Expert Opinion on Therapeutic Targets, 2019, 23, 215
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A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome

Juan Antonio Contreras Vite, Alexandria Tiffinger, Léa Théroux, Nathalie Morin, Mannix Auger-Messier, Pierre-Luc Boudreault, Philippe Sarret, Olivier Lesur and Robert Dumaine

IJMS, 2025, 26, 2735
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Éric Marsault (1971–2021): A Legacy through the Prism of Relationship Chemistry

Philippe Sarret

J. Med. Chem., 2021, 64, 5221
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Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders

Adrien Flahault, Pierre Couvineau, Rodrigo Alvear-Perez, Xavier Iturrioz and Catherine Llorens-Cortes

Front. Endocrinol., 2017, 8
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International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand

Cai Read, Duuamene Nyimanu, Thomas L. Williams, David J. Huggins, Petra Sulentic, Robyn G.C. Macrae, Peiran Yang, Robert C. Glen, Janet J. Maguire and Anthony P. Davenport

Pharmacological Reviews, 2019, 71, 467
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Apelin and Vasopressin: The Yin and Yang of Water Balance

Pierre-Emmanuel Girault-Sotias, Romain Gerbier, Adrien Flahault, Nadia de Mota and Catherine Llorens-Cortes

Front. Endocrinol., 2021, 12
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The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders

Eric Marsault, Catherine Llorens‐Cortes, Xavier Iturrioz, Hyung J. Chun, Olivier Lesur, Gavin Y. Oudit and Mannix Auger‐Messier

Annals of the New York Academy of Sciences, 2019, 1455, 12
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The chemistry of the carbon-transition metal double and triple bond: Annual survey covering the year 2017

James W. Herndon

Coordination Chemistry Reviews, 2018, 377, 86
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Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond

Alexandre Murza, Kien Trân, Laurent Bruneau‐Cossette, Olivier Lesur, Mannix Auger‐Messier, Pierre Lavigne, Philippe Sarret and Éric Marsault

Peptide Science, 2019, 111
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Critical APJ receptor residues in extracellular domains that influence effector selectivity

Anisha Ashokan, Harikumar Sheela Harisankar, Mythili Kameswaran and Gopala Krishna Aradhyam

The FEBS Journal, 2021, 288, 6543
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APJ as Promising Therapeutic Target of Peptide Analogues in Myocardial Infarction- and Hypertension-Induced Heart Failure

Daniela Rossin, Roberto Vanni, Marco Lo Iacono, Caterina Cristallini, Claudia Giachino and Raffaella Rastaldo

Pharmaceutics, 2023, 15, 1408
DOI: 10.3390/pharmaceutics15051408

Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13

Léa Théroux, Robin Van Den Hauwe, Kien Trân, Justin Fournier, Michael Desgagné, Nathan Meneboo, Alexis Lavallée, Ulrike Fröhlich, Jérôme Côté, Charlie Hollanders, Jean-Michel Longpré, Alexandre Murza, Eric Marsault, Philippe Sarret, Pierre-Luc Boudreault and Steven Ballet

ACS Pharmacol. Transl. Sci., 2023, 6, 290
DOI: 10.1021/acsptsci.2c00219

Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup

Kyungsoo Shin, Muzaddid Sarker, Shuya K. Huang and Jan K. Rainey

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-14784-0

Metabolically stable apelin analogs: development and functional role in water balance and cardiovascular function

Pierre Couvineau and Catherine Llorens-Cortes

Clinical Science, 2025, 139, 131
DOI: 10.1042/CS20240955