Issue 36, 2024

Dual-/multi-organelle-targeted AIE probes associated with oxidative stress for biomedical applications

Abstract

In situ monitoring of biological processes between different organelles upon oxidative stress is one of the most important research hotspots. Fluorescence imaging is especially suitable for biomedical applications due to its distinct advantages of high spatiotemporal resolution, high sensitivity, non-invasiveness, and in situ monitoring capabilities. However, most fluorescent probes can only achieve light-up imaging of single organelles, thus the combined use of two or more probes is usually required for monitoring biological processes between organelles, which can suffer from tedious staining and washing procedures, increased cytotoxicity and poor photostability. Exogenetic oxidants can affect broad-spectrum subcellular organelles, which are not conducive to in situ monitoring of biological processes between specific organelles. To tackle these challenges, a series of dual-/multi-organelle-targeted aggregation-induced emission (AIE) probes associated with oxidative stress have been designed and developed in the past few years. Herein, the recent progress of these AIE probes is summarized in biomedical applications, such as apoptosis monitoring, interplay between organelles, microenvironmental changes of organelles, organelle morphology tracking, precise cancer therapy, and so forth. Moreover, the further outlook for dual-/multi-organelle-targeted AIE probes is discussed, aiming to promote innovative research in biomedical applications.

Graphical abstract: Dual-/multi-organelle-targeted AIE probes associated with oxidative stress for biomedical applications

Article information

Article type
Review Article
Submitted
01 jul. 2024
Accepted
01 ago. 2024
First published
02 ago. 2024

J. Mater. Chem. B, 2024,12, 8812-8824

Dual-/multi-organelle-targeted AIE probes associated with oxidative stress for biomedical applications

Y. You, S. Lin, C. Tang, Y. Li, D. Yan, D. Wang and X. Chen, J. Mater. Chem. B, 2024, 12, 8812 DOI: 10.1039/D4TB01440E

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