Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers†
Kelly A. D. F.
Castro, 
‡*a
Letícia D.
Costa,
‡b
Samuel
Guieu,
bc
Juliana C.
Biazzotto,
a
Maria da Graça P. M. S.
Neves,
b
M. Amparo F.
Faustino,
*b
Roberto
S. da Silva
*a
and
Augusto C.
Tomé
*b
‡*a
Letícia D.
Costa,
‡b
Samuel
Guieu,
bc
Juliana C.
Biazzotto,
a
Maria da Graça P. M. S.
Neves,
b
M. Amparo F.
Faustino,
*b
Roberto
S. da Silva
*a
and
Augusto C.
Tomé
*b
Abstract
In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most phototoxic (at 2.5 μM) towards B16F10 cells.
- This article is part of the themed collection: The World Congress on Light and Life, Barcelona 2019
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