Issue 38, 2018

Nanoparticle–proteome in vitro and in vivo

Abstract

The protein corona is a concept central to a range of disciplines exploiting the bio–nano interface. As the literature continues to expand in this field, it is essential to condense and contextualize the in vitro and in vivo proteome databases accumulated over the past decade: a goal which this review intends to achieve for the benefit of nanomedicine and nanobiotechnology. The parameters used for our review are the physicochemical characteristics of the nanoparticles, their surface ligands, the biological matrix from which a corona was formed, methods employed, plus the top-ten enriched corona proteins. In addition, the protein coronal networks and their implications in vivo are highlighted for selected studies.

Graphical abstract: Nanoparticle–proteome in vitro and in vivo

Supplementary files

Article information

Article type
Review Article
Submitted
21 jun. 2018
Accepted
30 jul. 2018
First published
30 jul. 2018

J. Mater. Chem. B, 2018,6, 6026-6041

Nanoparticle–proteome in vitro and in vivo

M. Wang, O. J. R. Gustafsson, E. H. Pilkington, A. Kakinen, I. Javed, A. Faridi, T. P. Davis and P. C. Ke, J. Mater. Chem. B, 2018, 6, 6026 DOI: 10.1039/C8TB01634H

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