Issue 4, 2016

Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

Abstract

A novel gold-catalyzed tandem alkyne amination/intramolecular O–H insertion has been developed. A variety of [1,4]oxazino[3,2-c]isoquinolines are readily accessed under mild reaction conditions by utilizing this strategy, thereby providing an efficient and practical route for the construction of synthetically useful fused isoquinolines.

Graphical abstract: Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

Supplementary files

Article information

Article type
Research Article
Submitted
20 ene. 2016
Accepted
12 feb. 2016
First published
12 feb. 2016

Org. Chem. Front., 2016,3, 491-495

Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

Y. Pan, G. Chen, C. Shen, W. He and L. Ye, Org. Chem. Front., 2016, 3, 491 DOI: 10.1039/C6QO00033A

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