Issue 40, 2015

Strategies for skeletal muscle tissue engineering: seed vs. soil

Abstract

The most commonly used tissue engineering approach includes the ex vivo combination of site-appropriate cell(s) and scaffold material(s) to create three-dimensional constructs for tissue replacement or reconstruction. These three-dimensional combinations are typically subjected to a period of culture and conditioning (i.e., self-assembly and maturation) to promote the development of ex vivo constructs which closely mimic native target tissue. This cell-based approach is challenged by the host response to the engineered tissue construct following surgical implantation. As an alternative to the cell-based approach, acellular biologic scaffolds attract endogenous cells and remodel into partially functional mimics of native tissue upon implantation. The present review examines cell-types (i.e., seed), scaffold materials (i.e., soil), and challenges associated with functional tissue engineering. Skeletal muscle is used as the target tissue prototype but the discussed principles will largely apply to most body systems.

Graphical abstract: Strategies for skeletal muscle tissue engineering: seed vs. soil

Article information

Article type
Review Article
Submitted
20 ago. 2015
Accepted
08 sep. 2015
First published
17 sep. 2015

J. Mater. Chem. B, 2015,3, 7881-7895

Strategies for skeletal muscle tissue engineering: seed vs. soil

B. M. Sicari, R. Londono and S. F. Badylak, J. Mater. Chem. B, 2015, 3, 7881 DOI: 10.1039/C5TB01714A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements